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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Burkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Potassium 1UniRule annotation1
Metal bindingi93Potassium 1UniRule annotation1
Active sitei162Charge relay systemUniRule annotation1
Metal bindingi180Potassium 1; via carbonyl oxygenUniRule annotation1
Binding sitei209NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi245Potassium 2; via carbonyl oxygenUniRule annotation1
Sitei247Seems to be a necessary countercharge to the potassium cationsUniRule annotation1
Active sitei251Proton acceptorUniRule annotation1
Binding sitei285NAD/NADPUniRule annotation1
Binding sitei386NAD/NADPUniRule annotation1
Metal bindingi456Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi459Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei463Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 153NAD/NADPUniRule annotation4
Nucleotide bindingi176 – 179NAD/NADPUniRule annotation4
Nucleotide bindingi228 – 233NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayi
UPA00529;UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
Ordered Locus Names:Bcep1808_3430
OrganismiBurkholderia vietnamiensis (strain G4 / LMG 22486) (Burkholderia cepacia (strain R1808))
Taxonomic identifieri269482 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002287 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000470411 – 489NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi269482.Bcep1808_3430

Structurei

3D structure databases

ProteinModelPortaliA4JJG5
SMRiA4JJG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00130
OMAiITWINTW
OrthoDBiPOG091H05FS

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

A4JJG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVYGLQRLY IGGAYVDATS GKTFDTFDPA TGELLAQVQQ ASAADVDRAV
60 70 80 90 100
ASAQQGQREW AALTAMQRSR ILRRAVDLLR ERNDELAAIE TRDTGKPIGE
110 120 130 140 150
TLAVDIVTGA DVIEYYAGLA TAIEGLQVPL RAESFVYTRR EPLGVCAGIG
160 170 180 190 200
AWNYPIQIAC WKTAPALAAG NAMVFKPSEV TPLTALKLAE IYTEAGVPAG
210 220 230 240 250
VFNVVQGDGS VGALLTGHPD IAKVSFTGGV ETGKKVMSLA GASSLKEVTM
260 270 280 290 300
ELGGKSPLIV FDDADLDRAA DIAVIANFFS SGQVCTNGTR VFVQRSIKDA
310 320 330 340 350
FTAKVLERVK RIRVGKPTDA DTNFGPLVSA AQLDKVLGFI ASGKAEGAKL
360 370 380 390 400
LAGGTRLTDG HFADGQYVAP TVFGDCRDDM KIVREEIFGP VMSILDFESE
410 420 430 440 450
DEVIARANDT HYGLAAGVVT ENLSRAHRTI HRLEAGICWI NTWGESPAEM
460 470 480
PVGGYKQSGV GRENGITTLE HYTRIKSVQV ELGRYNPVF
Length:489
Mass (Da):52,239
Last modified:May 1, 2007 - v1
Checksum:i8B33A3AEA4223651
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000615 Genomic DNA Translation: ABO56418.1

Genome annotation databases

EnsemblBacteriaiABO56418; ABO56418; Bcep1808_3430
KEGGibvi:Bcep1808_3430

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000615 Genomic DNA Translation: ABO56418.1

3D structure databases

ProteinModelPortaliA4JJG5
SMRiA4JJG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269482.Bcep1808_3430

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO56418; ABO56418; Bcep1808_3430
KEGGibvi:Bcep1808_3430

Phylogenomic databases

eggNOGiENOG4105C26 Bacteria
COG1012 LUCA
HOGENOMiHOG000271505
KOiK00130
OMAiITWINTW
OrthoDBiPOG091H05FS

Enzyme and pathway databases

UniPathwayi
UPA00529;UER00386

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBETB_BURVG
AccessioniPrimary (citable) accession number: A4JJG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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