Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 83 (02 Dec 2020)
Sequence version 1 (01 May 2007)
Previous versions | rss
Add a publicationFeedback
Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

addB

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi792Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi1111Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi1114Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi1120Iron-sulfur (4Fe-4S)UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi8 – 15ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
Ligand4Fe-4S, ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
DRED349161:G1G8H-1547-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease AddBUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:addBUniRule annotation
Ordered Locus Names:Dred_1415
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDesulfotomaculum reducens (strain MI-1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri349161 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001556 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003791891 – 1155ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1155

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A4J4E2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of AddA and AddB.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
349161.Dred_1415

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A4J4E2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 300UvrD-like helicase ATP-bindingUniRule annotationAdd BLAST300
Domaini280 – 590UvrD-like helicase C-terminalUniRule annotationAdd BLAST311

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 1 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG3857, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007838_0_0_9

Identification of Orthologs from Complete Genome Data

More...
OMAi
DRLENYV

Database of Orthologous Groups

More...
OrthoDBi
1283891at2

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01452, AddB_type1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014140, DNA_helicase_suAddB
IPR014017, DNA_helicase_UvrD-like_C
IPR000212, DNA_helicase_UvrD/REP
IPR027417, P-loop_NTPase
IPR038726, PDDEXK_AddAB-type
IPR014016, UvrD-like_ATP-bd

The PANTHER Classification System

More...
PANTHERi
PTHR11070, PTHR11070, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12705, PDDEXK_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02773, addB_Gpos, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51198, UVRD_HELICASE_ATP_BIND, 1 hit
PS51217, UVRD_HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4J4E2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRFIVGRA GSGKSHSCLE EVRQRLRQNQ GESSIILLVP EQATFQYEYM
60 70 80 90 100
LATTPELKGM IWAQVLSFRR LAFRVLQEMG GAARAHIDDL GKKMVLRRIL
110 120 130 140 150
EQRKSELKVF HRAAKQPGFA DSLASALSEL KLYRIEPQEL QKGIQHMQEA
160 170 180 190 200
PGSAIRDKLA DLSLLYNDLE EFLSGRFTDP DDYLNLLAQR LPGSRTVQGA
210 220 230 240 250
EIFIDGFTGF TPQEYGVIEQ MLGTADRVHV ALCFDPMYLQ EPCDELEFFY
260 270 280 290 300
PTVETYHTLL DMAGALRISL EPPIICGKET PVRFQKDSAI AHLEKYYFRH
310 320 330 340 350
PLQASDAAQG VSLVACANRR AEVEAAAREI IRLCREEELS WRDIVVVLRD
360 370 380 390 400
LTNYSDLINT IFNDHGIPVF IDEKRNVLHH PLVELIRSAL EVITQHWAYD
410 420 430 440 450
PVFRYLKTDL IPVQRDDVDR LENYVLAHGI RGNRWNDNRD WTYRRQYTLG
460 470 480 490 500
EDCDIDDNEA EQLAQLNVVR YAAIEHINNF SKKVANCGNV RQITTALFEL
510 520 530 540 550
LESLSVAERM EAWAKEAEVA GRLIEAKEHA QIWDNVILLL DEIVEAMGEQ
560 570 580 590 600
ELNLEEYLQV LEAGLESLKL GLIPPGLDQV VVGTLERSRN PNVKAALVLG
610 620 630 640 650
ISDGVLPARP VEEGLFSDYE REALREIGLN LAPGARRKLF DEQYLIYTAL
660 670 680 690 700
TRASSRLWLS YPQADDEGKA LMPSPVIQRV KELLPLIQEE ILPVEPPCLG
710 720 730 740 750
GDLAFIANPS RSLSYLAAML RETVAGRLVD PVWQDVYSWF VQQPQYQESC
760 770 780 790 800
RRVLAGLYHV NQETSLPPSM GRRLYGSRLR ASVSRLERFT TCPFSHFLSH
810 820 830 840 850
GLKLKERSQF KLAAPDLGQF FHAALKLFAE RIKALSLDWG QLSRGQIITI
860 870 880 890 900
TGEIVEELAP QLQNEILLST ARHRYLIKKL RRTLERAVVT LAEHARRGSF
910 920 930 940 950
RPVAVEIGFG DNAELPAVQL DLADHCQMEM AGRIDRIDSA CEGGQHYYSL
960 970 980 990 1000
IDYKSGQPDI KLADIVHGLK LQLLTYLDVA LRYSKQLTQQ EALPAAMLYF
1010 1020 1030 1040 1050
SVRDPFVAST GPMTEEEAEK NLLKQLKMKG LLLADPLVIS KMDKELSGQS
1060 1070 1080 1090 1100
DLLPVGLKKN GDFYSNSRVI TEEQFKLLRN YLEFKLKSIG QQMVSGDIAI
1110 1120 1130 1140 1150
SPYQRGKEKA CRYCIFKSVC QFDPLLEDNL FRLLADQEEQ VLWSLIKESL

GDKHE
Length:1,155
Mass (Da):131,126
Last modified:May 1, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6F9CC93B3F3EB59
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000612 Genomic DNA Translation: ABO49945.1

NCBI Reference Sequences

More...
RefSeqi
WP_011877764.1, NC_009253.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ABO49945; ABO49945; Dred_1415

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
drm:Dred_1415

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA Translation: ABO49945.1
RefSeqiWP_011877764.1, NC_009253.1

3D structure databases

SMRiA4J4E2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi349161.Dred_1415

Proteomic databases

PRIDEiA4J4E2

Genome annotation databases

EnsemblBacteriaiABO49945; ABO49945; Dred_1415
KEGGidrm:Dred_1415

Phylogenomic databases

eggNOGiCOG3857, Bacteria
HOGENOMiCLU_007838_0_0_9
OMAiDRLENYV
OrthoDBi1283891at2

Enzyme and pathway databases

BioCyciDRED349161:G1G8H-1547-MONOMER

Family and domain databases

HAMAPiMF_01452, AddB_type1, 1 hit
InterProiView protein in InterPro
IPR014140, DNA_helicase_suAddB
IPR014017, DNA_helicase_UvrD-like_C
IPR000212, DNA_helicase_UvrD/REP
IPR027417, P-loop_NTPase
IPR038726, PDDEXK_AddAB-type
IPR014016, UvrD-like_ATP-bd
PANTHERiPTHR11070, PTHR11070, 1 hit
PfamiView protein in Pfam
PF12705, PDDEXK_1, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR02773, addB_Gpos, 1 hit
PROSITEiView protein in PROSITE
PS51198, UVRD_HELICASE_ATP_BIND, 1 hit
PS51217, UVRD_HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADDB_DESRM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4J4E2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: May 1, 2007
Last modified: December 2, 2020
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again