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Entry version 70 (11 Dec 2019)
Sequence version 1 (01 May 2007)
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Protein

Anthranilate 3-monooxygenase oxygenase component

Gene

hpaH

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Utilizes FADH2 supplied by NAD(P)H-dependent FAD/FMN reductase (GTNG_3158) to catalyze the hydroxylation of anthranilate producing 3-hydroxyanthranilate. Preferred substrate is anthranilate but it can also utilize 2-hydroxyphenylacetate, 4-hydroxyphenylacetate and salicylate but not kynurenine, phenol, 2-NBA, chlorobenzene, naphthalene, naphthol, toluene or ethylbenzene.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=151.3 µmol/min/mg enzyme toward anthranilate1 Publication

    pH dependencei

    Optimum pH is 9.0. Active from pH 5 to 11.1 Publication

    Temperature dependencei

    Optimum temperature is 60 degrees Celsius. Active from 25 to 70 degrees Celsius.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei151SubstrateBy similarity1
    Binding sitei194FADBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi151 – 153FADBy similarity3
    Nucleotide bindingi157 – 160FADBy similarity4
    Nucleotide bindingi457 – 460FADBy similarity4

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMonooxygenase, Oxidoreductase
    Biological processAromatic hydrocarbons catabolism
    LigandFAD, Flavoprotein

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-15633

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Anthranilate 3-monooxygenase oxygenase component1 PublicationBy similarity (EC:1.14.14.81 Publication)
    Alternative name(s):
    4-hydroxyphenylacetate 3-monooxygenase oxygenase componentBy similarity (EC:1.14.14.9By similarity)
    Short name:
    4 HPA 3-hydroxylaseBy similarity
    Anthranilate 3-hydroxylase1 PublicationBy similarity
    Anthranilate hydroxylase1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:hpaHBy similarity
    Ordered Locus Names:GTNG_3160
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGeobacillus thermodenitrificans (strain NG80-2)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri420246 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001578 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004202341 – 494Anthranilate 3-monooxygenase oxygenase componentAdd BLAST494

    Proteomic databases

    PRoteomics IDEntifications database

    More...
    PRIDEi
    A4IT51

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Anthranilate 3-monooxygenase consists of a reductase component (GTNG_3158) and an oxygenase component HpaH.

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    420246.GTNG_3160

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    A4IT51

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 109Substrate bindingBy similarity5
    Regioni207 – 208Substrate bindingBy similarity2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the FADH(2)-utilizing monooxygenase family.Sequence analysis

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105EFA Bacteria
    COG2368 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000145842

    KEGG Orthology (KO)

    More...
    KOi
    K16901

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HAIINPQ

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036250 AcylCo_DH-like_C
    IPR009100 AcylCoA_DH/oxidase_NM_dom
    IPR004925 HpaB/PvcC/4-BUDH
    IPR024719 HpaB/PvcC/4-BUDH_C
    IPR024674 HpaB/PvcC/4-BUDH_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR36117 PTHR36117, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03241 HpaB, 1 hit
    PF11794 HpaB_N, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000331 HpaA_HpaB, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47203 SSF47203, 1 hit
    SSF56645 SSF56645, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A4IT51-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRMGIRTGAQ YISGLKSRKP EIWLSGRRVI NVCEEPVFKQ PIREIARLYD
    60 70 80 90 100
    MQHDPEYQDK ITHICTETGE RVSNAFLVPK SREDLLARRA LFEVWARATF
    110 120 130 140 150
    GLMGRTPDFL NVVLTSLYSN ASFLEKYNPQ WAENIRAYYR YVRDNDLFLT
    160 170 180 190 200
    HAIINPQNDR SKPSHEQQDT FTHLGVVRET PEGLIVRGAK MLATLAPITD
    210 220 230 240 250
    EVIIYTFPGY KPGDERYAVS FAIPIDTPGL RILCREPMQD GTRPLFDHPL
    260 270 280 290 300
    ASRFEEMDAL LVFNDVLVPW DRVFIYNNVE AANLLYPKTG IAQQPAHQTG
    310 320 330 340 350
    VRGLIKLQFA TEVAIRLADS IGVDVYLNVQ NDLGELLQSV EAIRALLHLA
    360 370 380 390 400
    EHELEVLPSG EVMPGWVPLE TIRGLLPKLY PRAVEVLQII GAGGLLMSPT
    410 420 430 440 450
    GADFANPELA ADMEKYYAGR IGVGGEERVR LFKLAWDLCG EAFGQRLLQY
    460 470 480 490
    ERFYTGDPIR KRAIFYNNIK RERTLVMVDE ALRMPNQQEK VVNA
    Length:494
    Mass (Da):56,164
    Last modified:May 1, 2007 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE503A3E68B96F86
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP000557 Genomic DNA Translation: ABO68505.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    ABO68505; ABO68505; GTNG_3160

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    gtn:GTNG_3160

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP000557 Genomic DNA Translation: ABO68505.1

    3D structure databases

    SMRiA4IT51
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi420246.GTNG_3160

    Proteomic databases

    PRIDEiA4IT51

    Genome annotation databases

    EnsemblBacteriaiABO68505; ABO68505; GTNG_3160
    KEGGigtn:GTNG_3160

    Phylogenomic databases

    eggNOGiENOG4105EFA Bacteria
    COG2368 LUCA
    HOGENOMiHOG000145842
    KOiK16901
    OMAiHAIINPQ

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-15633

    Family and domain databases

    InterProiView protein in InterPro
    IPR036250 AcylCo_DH-like_C
    IPR009100 AcylCoA_DH/oxidase_NM_dom
    IPR004925 HpaB/PvcC/4-BUDH
    IPR024719 HpaB/PvcC/4-BUDH_C
    IPR024674 HpaB/PvcC/4-BUDH_N
    PANTHERiPTHR36117 PTHR36117, 1 hit
    PfamiView protein in Pfam
    PF03241 HpaB, 1 hit
    PF11794 HpaB_N, 1 hit
    PIRSFiPIRSF000331 HpaA_HpaB, 1 hit
    SUPFAMiSSF47203 SSF47203, 1 hit
    SSF56645 SSF56645, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHPAH_GEOTN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4IT51
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2012
    Last sequence update: May 1, 2007
    Last modified: December 11, 2019
    This is version 70 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
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