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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:GTNG_3026
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000632811 – 207ATP phosphoribosyltransferaseAdd BLAST207

Proteomic databases

PRIDEiA4ISR7

Interactioni

Subunit structurei

Heteromultimer composed of HisG and HisZ subunits.UniRule annotation

Protein-protein interaction databases

STRINGi420246.GTNG_3026

Structurei

3D structure databases

ProteinModelPortaliA4ISR7
SMRiA4ISR7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Lacks the C-terminal regulatory region which is replaced by HisZ.

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E21 Bacteria
COG0040 LUCA
HOGENOMiHOG000223248
KOiK00765
OMAiYVMMDYD
OrthoDBiPOG091H05D7

Family and domain databases

CDDicd13595 PBP2_HisGs, 1 hit
HAMAPiMF_01018 HisG_Short, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR024893 ATP_PRibTrfase_HisG_short
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit

Sequencei

Sequence statusi: Complete.

A4ISR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTIAMPKGR IFEEAVELLR RADYMLPPEF EESRKLVIDV AEENMRFILA
60 70 80 90 100
KPMDVVTYVE HGVADLGIAG KDVLMEEERN VYELLDLQIS RCHLAVAGLP
110 120 130 140 150
GVKMNGIAPR VATKYPNVAS TYFREQGEQV EIIRLNGSIE LAPLIGLADR
160 170 180 190 200
IVDIVSTGRT LKENGLVELE RIADVTSRLI VNPASYRLNG EVIERLVDRL

AAVIPQP
Length:207
Mass (Da):23,078
Last modified:May 1, 2007 - v1
Checksum:i09594960F4DD2E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA Translation: ABO68371.1
RefSeqiWP_008880310.1, NC_009328.1

Genome annotation databases

EnsemblBacteriaiABO68371; ABO68371; GTNG_3026
GeneIDi31762276
KEGGigtn:GTNG_3026

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA Translation: ABO68371.1
RefSeqiWP_008880310.1, NC_009328.1

3D structure databases

ProteinModelPortaliA4ISR7
SMRiA4ISR7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420246.GTNG_3026

Proteomic databases

PRIDEiA4ISR7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO68371; ABO68371; GTNG_3026
GeneIDi31762276
KEGGigtn:GTNG_3026

Phylogenomic databases

eggNOGiENOG4105E21 Bacteria
COG0040 LUCA
HOGENOMiHOG000223248
KOiK00765
OMAiYVMMDYD
OrthoDBiPOG091H05D7

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00006

Family and domain databases

CDDicd13595 PBP2_HisGs, 1 hit
HAMAPiMF_01018 HisG_Short, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR024893 ATP_PRibTrfase_HisG_short
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHIS1_GEOTN
AccessioniPrimary (citable) accession number: A4ISR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: October 10, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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