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Protein

Imidazole glycerol phosphate synthase subunit HisH

Gene

hisH

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.UniRule annotation

Catalytic activityi

5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H2O.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81NucleophileUniRule annotation1
Active sitei188UniRule annotation1
Active sitei190UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00010

Protein family/group databases

MEROPSiC26.965

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazole glycerol phosphate synthase subunit HisHUniRule annotation (EC:2.4.2.-UniRule annotation)
Alternative name(s):
IGP synthase glutamine amidotransferase subunitUniRule annotation
IGP synthase subunit HisHUniRule annotation
ImGP synthase subunit HisHUniRule annotation
Short name:
IGPS subunit HisHUniRule annotation
Gene namesi
Name:hisHUniRule annotation
Ordered Locus Names:GTNG_3023
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001193761 – 213Imidazole glycerol phosphate synthase subunit HisHAdd BLAST213

Interactioni

Subunit structurei

Heterodimer of HisH and HisF.UniRule annotation

Protein-protein interaction databases

STRINGi420246.GTNG_3023

Structurei

3D structure databases

ProteinModelPortaliA4ISR4
SMRiA4ISR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 213Glutamine amidotransferase type-1UniRule annotationAdd BLAST211

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4108UJE Bacteria
COG0118 LUCA
HOGENOMiHOG000025030
KOiK02501
OMAiWVYFVHS
OrthoDBiPOG091H03NT

Family and domain databases

CDDicd01748 GATase1_IGP_Synthase, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00278 HisH, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR010139 Imidazole-glycPsynth_HisH
PANTHERiPTHR42701 PTHR42701, 1 hit
PfamiView protein in Pfam
PF00117 GATase, 1 hit
PIRSFiPIRSF000495 Amidotransf_hisH, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
TIGRFAMsiTIGR01855 IMP_synth_hisH, 1 hit
PROSITEiView protein in PROSITE
PS51273 GATASE_TYPE_1, 1 hit

Sequencei

Sequence statusi: Complete.

A4ISR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMIGVIDYG MGNLYSVSKA LERLGCPYIV SGDKEELARV RGLILPGVGS
60 70 80 90 100
FRDAMHILRE TGLADFIRSA VQDGTPLLGI CLGMQLLFDE SEENGPTEGL
110 120 130 140 150
GLLRGRVVRF PGVTNDGEPY KVPHMGWNRL RFHRSSPLLD GVEEGHVYFV
160 170 180 190 200
HSYYVVPGEE EVVLASSEYD VDVPAVVGRD NVFGTQFHPE KSGAVGMSIL
210
NRYVGIVTGR ENG
Length:213
Mass (Da):23,302
Last modified:May 1, 2007 - v1
Checksum:iB52B54ED1A9A4BA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA Translation: ABO68368.1
RefSeqiWP_008880307.1, NC_009328.1

Genome annotation databases

EnsemblBacteriaiABO68368; ABO68368; GTNG_3023
GeneIDi31762273
KEGGigtn:GTNG_3023

Similar proteinsi

Entry informationi

Entry nameiHIS5_GEOTN
AccessioniPrimary (citable) accession number: A4ISR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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