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Entry version 79 (31 Jul 2019)
Sequence version 1 (01 May 2007)
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Protein
Submitted name:

Shank2 protein

Gene

shank2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Shank2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:shank2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-984534 shank2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 198SH3InterPro annotationAdd BLAST60
Domaini239 – 333PDZInterPro annotationAdd BLAST95
Domaini1397 – 1460SAMInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 36DisorderedSequence analysisAdd BLAST20
Regioni74 – 98DisorderedSequence analysisAdd BLAST25
Regioni338 – 359DisorderedSequence analysisAdd BLAST22
Regioni438 – 461DisorderedSequence analysisAdd BLAST24
Regioni494 – 555DisorderedSequence analysisAdd BLAST62
Regioni651 – 672DisorderedSequence analysisAdd BLAST22
Regioni766 – 820DisorderedSequence analysisAdd BLAST55
Regioni835 – 854DisorderedSequence analysisAdd BLAST20
Regioni874 – 908DisorderedSequence analysisAdd BLAST35
Regioni943 – 972DisorderedSequence analysisAdd BLAST30
Regioni1105 – 1124DisorderedSequence analysisAdd BLAST20
Regioni1255 – 1286DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili369 – 389Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi74 – 97PolarSequence analysisAdd BLAST24
Compositional biasi498 – 522Pro-richSequence analysisAdd BLAST25
Compositional biasi535 – 553PolarSequence analysisAdd BLAST19
Compositional biasi766 – 784PolarSequence analysisAdd BLAST19
Compositional biasi797 – 811PolarSequence analysisAdd BLAST15
Compositional biasi884 – 908PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1267 – 1286PolarSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293276

KEGG Orthology (KO)

More...
KOi
K15009

Database of Orthologous Groups

More...
OrthoDBi
36120at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4IIJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLFSAFTK KEVPFREAPS YSHRRRGPQS TLAAPRVLLR SNSDNNLNVN
60 70 80 90 100
NLPEWSASSA SLHRSLSPQL LQQMQNNPNG TVKTIGSYAQ VPRSRSPSLN
110 120 130 140 150
RLGEDAKRQQ HRHISPGANK ESAPALDFQG PKRKLYSALP GRHFIVVKSY
160 170 180 190 200
QPQGEGEIPL HKGDRIRVLS IGEGGFWEGN ARGHVGWFPA ECVEEIQPKP
210 220 230 240 250
SDGRPETRTD RTKKLFRHYT VGSYDSFDAS SDCIIEEKTV VLQKKDNEGF
260 270 280 290 300
GFVLRGAKAD TPIEEFNPTP AFPALQYLES VDEDGVAWQA GLRTGDFLIE
310 320 330 340 350
VNNENVVKVG HRQVVNMIRQ GGNHLVLKVV TVTRNLDPDD TARKKAPPPP
360 370 380 390 400
KRAPTTALSL RSKSMTSELE ELAVDIASVR RRKDKAEDSG PIPKPLRPLD
410 420 430 440 450
NAAVDSRIAT VKQRPTSRCF PAATDTNSMY DRQGIAVIPP TAPGSHQGPF
460 470 480 490 500
LGIPRGTMRR QKSIDSRIPL SGITEEERQF LAPPMLKFTR SLSMPDASED
510 520 530 540 550
IPPPPATLPP SPPPPSPSSF NSPKSPAPRG YGTIKPAFTQ NSGTKSPSPA
560 570 580 590 600
VRSDNVGTIA RDKSMFYRHE ANRFSLDSEE LYNASMANQQ NFINKRSKMP
610 620 630 640 650
ENPYSEVGKL GNKAVYVPAK PARRKGMLVK QSNVEDSPEK TCSIPIPTII
660 670 680 690 700
IKEPSTSSSG KSSQGSSMET DLQISEQVGQ LRPDDSLNAS SPFAAAIAGA
710 720 730 740 750
VRDREKRLEA RRNSPAFLST DLGDECVGPK PSPRLQHSKS IDDGMFFNDE
760 770 780 790 800
HTKHLMAPSS LVLPRGSSNA FTNNDSSHQG DVSNARMSKI KGPENNAAPA
810 820 830 840 850
KSTNSSGNYM HPVTGKLLDP NSPLALALAA RDRALKDQNQ PSPSPTDPEK
860 870 880 890 900
ADLNKPLYID TKLRSGLESS FSVATINANR PNQRGKLKRQ ETESKHDLDS
910 920 930 940 950
SKEEKRQEEK KNMLINIMDT SQQKTAGLLM VHTVDTTKAD DALAESEEAE
960 970 980 990 1000
KGTPPENSNA PVSEPREELE NSLPKANVLG TPAAPLNKAI VSVCSVEEPV
1010 1020 1030 1040 1050
ILPFRIPPPP FASMDVDEDF IFTEPLPPPL EFANSFEIPE DASQMPPATL
1060 1070 1080 1090 1100
ADLLIQRKNG AFLPPSFNPN VASNSIDSKR PAVLTNCLPT SFMQHPESFD
1110 1120 1130 1140 1150
NVTDSGIEEA DSRSGSDHHL ETTSTISTVS SISTLSSEGG ENLDTCTVYA
1160 1170 1180 1190 1200
DGQAFLVDKP PVPPKPKVKP IINKSNALYK DAVLEENLDN FPVPPPAPPP
1210 1220 1230 1240 1250
LPLSIQPSMT KAGQQRTSKL WGDNTEVKSP VMPSPKANVI SELNSILQQM
1260 1270 1280 1290 1300
NREKATKPGE GLDSPTGMKT ANLSTRGTDA LSTVSGNRST TVTFTIRPGA
1310 1320 1330 1340 1350
NQPISLQNRT PEFEGRVTGM RRAPSPVVSP AEITRDIKPG PLSAPPASMS
1360 1370 1380 1390 1400
DVFILPSQPP SGDMFGMSMG RSRSPSPSIL QQPISNKPFS AKPVHMWTKQ
1410 1420 1430 1440 1450
DVADWLESLH LGEHKEMFMD NEIDGTHLPN LQKEDLIDLG VTRVGHRMNI
1460
ERALKQLLDR
Length:1,460
Mass (Da):159,318
Last modified:May 1, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i154AC934934520F0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC136044 mRNA Translation: AAI36045.1

NCBI Reference Sequences

More...
RefSeqi
NP_001096183.1, NM_001102713.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100124731

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100124731

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136044 mRNA Translation: AAI36045.1
RefSeqiNP_001096183.1, NM_001102713.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100124731
KEGGixtr:100124731

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22941
XenbaseiXB-GENE-984534 shank2

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4375 Eukaryota
COG0666 LUCA
HOGENOMiHOG000293276
KOiK15009
OrthoDBi36120at2759

Family and domain databases

Gene3Di1.10.150.50, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF00536 SAM_1, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4IIJ6_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4IIJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: July 31, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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