UniProtKB - A4IIA2 (IBP2_XENTR)
Protein
Insulin-like growth factor-binding protein 2
Gene
igfbp2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity).By similarity
GO - Molecular functioni
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
- regulation of growth Source: UniProtKB-KW
- regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Growth factor binding |
Biological process | Growth regulation |
Enzyme and pathway databases
Reactomei | R-XTR-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 2By similarityShort name: IGF-binding protein 2By similarity Short name: IGFBP-2By similarity |
Gene namesi | Name:igfbp2Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-487299, igfbp2 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000381737 | 22 – 284 | Insulin-like growth factor-binding protein 2Sequence analysisAdd BLAST | 263 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 187 ↔ 221 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 232 ↔ 243 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 245 ↔ 266 | PROSITE-ProRule annotationBy similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | A4IIA2 |
Interactioni
Subunit structurei
Interacts with igf1 and igf2.
By similarityGO - Molecular functioni
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000042987 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 106 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 184 – 266 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 83 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 261 – 263 | Cell attachment siteSequence analysis | 3 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
GeneTreei | ENSGT00940000158542 |
InParanoidi | A4IIA2 |
OrthoDBi | 979270at2759 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A4IIA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLSRYLLGL LLGVLCTPAP AEVLFRCPPC SPERLATCPG SAPRPPCAEL
60 70 80 90 100
VRAPGCGCCP VCARLEGESC GVYTARCAGG LRCYPHPGSE LPLQALVLGL
110 120 130 140 150
GTCGKRRDTE YGSSQERGTE LPEERSDNML VDNKLEAGPA VAGEAAPRKP
160 170 180 190 200
SKKEMKEIAV TRERANEQQR SKSNKSEDKK RPARSLCQLQ LDQVLERISG
210 220 230 240 250
MHLPDDRGPL EHLYALHIPN CDKNGFFNLK QCKMSVNGQR GECWCVNPIT
260 270 280
GKALPGSPTI RGDPECHLYY TSPEEGRAHT QRAP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC135928 mRNA Translation: AAI35929.1 |
RefSeqi | NP_001093707.1, NM_001100237.1 |
Genome annotation databases
Ensembli | ENSXETT00000094605; ENSXETP00000070923; ENSXETG00000035913 |
GeneIDi | 100101720 |
KEGGi | xtr:100101720 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC135928 mRNA Translation: AAI35929.1 |
RefSeqi | NP_001093707.1, NM_001100237.1 |
3D structure databases
SMRi | A4IIA2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000042987 |
Proteomic databases
PaxDbi | A4IIA2 |
Genome annotation databases
Ensembli | ENSXETT00000094605; ENSXETP00000070923; ENSXETG00000035913 |
GeneIDi | 100101720 |
KEGGi | xtr:100101720 |
Organism-specific databases
CTDi | 3485 |
Xenbasei | XB-GENE-487299, igfbp2 |
Phylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
GeneTreei | ENSGT00940000158542 |
InParanoidi | A4IIA2 |
OrthoDBi | 979270at2759 |
Enzyme and pathway databases
Reactomei | R-XTR-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP2_XENTR | |
Accessioni | A4IIA2Primary (citable) accession number: A4IIA2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 1, 2009 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |