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Protein

Notch-regulated ankyrin repeat-containing protein

Gene

nrarp

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Promotes loss of intracellular domain (ICD) of Notch1 in embryos. By down-regulating ICD levels, could function as a negative feedback regulator of Notch signaling that attenuates ICD-mediated transcription (By similarity). Involved in angiogenesis. May be involved in somitogenesis (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Notch-regulated ankyrin repeat-containing protein
Gene namesi
Name:nrarp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-996958 nrarp

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003250841 – 114Notch-regulated ankyrin repeat-containing proteinAdd BLAST114

Proteomic databases

PaxDbiA4II29

Expressioni

Gene expression databases

BgeeiENSXETG00000003952

Interactioni

Subunit structurei

Forms a ternary complex with the intracellular domain (ICD) of notch1 and rbpj/suh.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000008564

Structurei

3D structure databases

ProteinModelPortaliA4II29
SMRiA4II29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 79ANK 1Add BLAST30
Repeati83 – 112ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the NRARP family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000082661
HOVERGENiHBG097373
InParanoidiA4II29
OMAiIERCTSM
OrthoDBiEOG091G0WZR

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

A4II29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQAEMSTCS TPHTQRVFQE AVRKGNTKEL QSLLQNMTNC EFNVNSFGPE
60 70 80 90 100
GQTALHQSVI DGNLELVKLL VKFGADIRLA NRDGWSALHI AAYGGHQDIV
110
LYLITKAKYS SSSR
Length:114
Mass (Da):12,613
Last modified:May 1, 2007 - v1
Checksum:i1546DE296BAED194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135819 mRNA Translation: AAI35820.1
RefSeqiNP_001096349.1, NM_001102879.1
UniGeneiStr.64225

Genome annotation databases

EnsembliENSXETT00000008564; ENSXETP00000008564; ENSXETG00000003952
GeneIDi100124939
KEGGixtr:100124939

Similar proteinsi

Entry informationi

Entry nameiNRARP_XENTR
AccessioniPrimary (citable) accession number: A4II29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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