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Protein

Ribonuclease H1

Gene

rnaseh1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H1UniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase H1UniRule annotation
Gene namesi
Name:rnaseh1Imported
Synonyms:LOC100124876Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-1011883 rnaseh1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500267053224 – 299Ribonuclease H1Sequence analysisAdd BLAST276

Structurei

3D structure databases

ProteinModelPortaliA4IHP7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 293RNase HInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000040465
HOVERGENiHBG002135
KOiK03469

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.40.970.10, 1 hit
InterProiView protein in InterPro
IPR009027 Ribosomal_L9/RNase_H1_N
IPR017067 RNase_H1_euk
IPR011320 RNase_H1_N
IPR037056 RNase_H1_N_sf
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF01693 Cauli_VI, 1 hit
PF00075 RNase_H, 1 hit
PIRSFiPIRSF036852 Ribonuclease_H1_euk, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
SSF55658 SSF55658, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequencei

Sequence statusi: Complete.

A4IHP7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRIQNAFSS LHLLCSAVGG VHSTFMRMFY AVRTGRKPGV YNTWDECKEQ
60 70 80 90 100
VDKFPLARYK KFASEEDAWN FVRNQESSSK SSSVDTGETK EPPTQATGLH
110 120 130 140 150
NVVPQQRAKR PLYKAQSSST EEAAPKRTKL IDLTELPSSH NGAFKYMGDS
160 170 180 190 200
VVVYTDGCCS QNGRLKARAG IGVYWGLNHP LNLAEKLEGR QTNQRAEIQA
210 220 230 240 250
ACRALELAKS QNISKLVLYT DSMFTINGIT KWIHSWKRNG WKLTTGKKVI
260 270 280 290
NREDFEKLDK LTQGLDIKWM HIPGHAGFEG NEAADRLSRE GAQKSSEDQ
Length:299
Mass (Da):33,603
Last modified:May 1, 2007 - v1
Checksum:i1F09B8620C0F1098
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135622 mRNA Translation: AAI35623.1
RefSeqiNP_001096299.1, NM_001102829.1
UniGeneiStr.51968

Genome annotation databases

GeneIDi100124876
KEGGixtr:100124876

Similar proteinsi

Entry informationi

Entry nameiA4IHP7_XENTR
AccessioniPrimary (citable) accession number: A4IHP7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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