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Protein

Helicase ARIP4

Gene

rad54l2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi303 – 310ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase ARIP4 (EC:3.6.4.12)
Alternative name(s):
Androgen receptor-interacting protein 4
RAD54-like protein 2
Gene namesi
Name:rad54l2
Synonyms:arip4
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5829376 rad54l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157831 – 1396Helicase ARIP4Add BLAST1396

Proteomic databases

PaxDbiA4IHD2
PRIDEiA4IHD2

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000000131

Structurei

3D structure databases

ProteinModelPortaliA4IHD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 510Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST221
Domaini717 – 891Helicase C-terminalPROSITE-ProRule annotationAdd BLAST175

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi461 – 464DEAH box4
Motifi549 – 553LXXLL motif 15
Motifi1273 – 1277LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 71Glu-richAdd BLAST62

Domaini

Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1015 Eukaryota
COG0553 LUCA
HOVERGENiHBG104283
InParanoidiA4IHD2
KOiK10876

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

A4IHD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDASISGSE PELDPEDMEE EEEDDEDDDE EEEEEEDEED NDGDDEDDKQ
60 70 80 90 100
DINEKSQNAA LGEDSPEQGE EGWKRSTTSG QSGQESDEAK KKRLQKPANL
110 120 130 140 150
RRNIRKLLRE DQLESVTKTA QQEELERRKR LEQQRKDYPL PLTLPPVSLD
160 170 180 190 200
FLQEEIELRA ADVSQLVKSQ EIICLDSSSG ESDDEGKVKS HSIKDEIIEL
210 220 230 240 250
SSGEEDNLQI SDNADSTNEV DGDITTENSG SHVNDALNQA DHLGRVLVNI
260 270 280 290 300
NHPPNEKDIF LAPQLARAVK SHQIGGIRFL YDNLVESLER FSGSSGFGCI
310 320 330 340 350
LAHSMGLGKT LQVISFLDVL FQHTSAKTVL AIVPVNTLQN WLAEFNMWLP
360 370 380 390 400
PPESLPKDHN QELVQPRAFK VHTMNDEHKT TAARAKVVND WATDGGVLLM
410 420 430 440 450
GYEMYRLLSL KKSFTAGRKK KSKKAAGPVI IDLDEEDRQQ EMLKGIEKAL
460 470 480 490 500
SRPGPDVVIC DEGHRIKNCH ASTSQALKNI RSRRRVVLTG YPLQNNLIEY
510 520 530 540 550
WCMVDFVRPD FLGTRQEFSN MFERPILNGQ CVDSTPQDKR LMRYRSHVLH
560 570 580 590 600
SLLEGFVQRR GHTVLKAQLP FKEEHVILVR LSKIQRDLYT EFMNRFRDAG
610 620 630 640 650
NSGWLGLNPL KAFCVCCKIW NHPDVLYEAL QKENLANEQD LDVEDLGTNN
660 670 680 690 700
RCNAQSGKIK VEPNSLGALM GETAHTKQLQ GIVLNPSHEK ANQVVTYEWA
710 720 730 740 750
KEILSDYIPG QLQNSPKMVL LFHLIEESMR MGDKILVFSQ SLSTLSIMEE
760 770 780 790 800
FLAKRKMPIP AGSDGQEGHT WIRNVNYYRL DGSTSASERE RLINQFNDPS
810 820 830 840 850
NEKVWLFLLS TRAGCLGVNL IGANRVVVFD ASWNPCHDAQ AVCRVYRYGQ
860 870 880 890 900
RKPCYIYRLV SDFTLEKKIY DRQITKQGMS DRVVDDLNPE VNFTRREVEN
910 920 930 940 950
LLHFVEEEPD ASRQHLDSSS FHEAVLQKAC LQYPHLITKE PFQHESLLLD
960 970 980 990 1000
RKEQKLTLAE KKAAKRGYEE EKRASVPYTR PSYTQYYPAP DHNLGNIPAF
1010 1020 1030 1040 1050
SQRHWRPLMK GDDRPVASVR PLQSTPIPML PRHVSVNHPG SASASVHPYN
1060 1070 1080 1090 1100
FPVNYLQRAG VLVQKVVTTT DIVIPGMTTS TDVQARISAG ESIHVIRGTK
1110 1120 1130 1140 1150
GTYIRTSDGR IFAIRASGKQ KSGEVRRQAT SGAQGSSAPY LSNGRHSTSS
1160 1170 1180 1190 1200
PSQQDSEDPP RPLSPDSPEI LNELQKYADA AAARGSHTAP QLQNLGLHHQ
1210 1220 1230 1240 1250
GINPAPKLQP RKRKDPQDQS SHWPSNKRNP YSQLSYPNTG GFGVTPSTMN
1260 1270 1280 1290 1300
HNLVRSSNPV FMGPGGGSSH FQLPSLLSDP QTGLPLVQDS LLTHSSGTSS
1310 1320 1330 1340 1350
APSVPPHYLL PRGFPLPFSQ SLLPQTRMFA PYPSQILNRG LPTNNPASTF
1360 1370 1380 1390
PGYLSSHSNY QASPGTSSRP LPSGETELGS CEEDGRDDDV VEVTGE
Length:1,396
Mass (Da):156,367
Last modified:May 1, 2007 - v1
Checksum:i79566FD319FAA98B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC135473 mRNA Translation: AAI35474.1
RefSeqiNP_001076824.1, NM_001083355.1
UniGeneiStr.52506

Genome annotation databases

GeneIDi733747
KEGGixtr:733747

Similar proteinsi

Entry informationi

Entry nameiARIP4_XENTR
AccessioniPrimary (citable) accession number: A4IHD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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