UniProtKB - A4IGK4 (RBM5_XENTR)
Protein
RNA-binding protein 5
Gene
rbm5
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 186 – 215 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 671 – 696 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- mRNA binding Source: UniProtKB
- RNA binding Source: GO_Central
GO - Biological processi
- mRNA splicing, via spliceosome Source: GO_Central
- positive regulation of apoptotic process Source: UniProtKB
- regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
- spliceosomal complex assembly Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-XTR-72163, mRNA Splicing - Major Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein 5Alternative name(s): RNA-binding motif protein 5 |
Gene namesi | Name:rbm5 ORF Names:TGas113j08.1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-494987, rbm5 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB
- spliceosomal complex Source: UniProtKB-KW
Keywords - Cellular componenti
Nucleus, SpliceosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376808 | 1 – 838 | RNA-binding protein 5Add BLAST | 838 |
Proteomic databases
PRIDEi | A4IGK4 |
Expressioni
Gene expression databases
Bgeei | ENSXETG00000007303, Expressed in brain and 22 other tissues |
Interactioni
Subunit structurei
Component of the spliceosome A complex (also known as the prespliceosome). Appears to dissociate from the spliceosome upon formation of the spliceosome B complex (also known as the precatalytic spliceosome), in which the heterotrimeric U4/U6.U5 snRNPs are bound (By similarity).
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 183 | RRM 1PROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 242 – 326 | RRM 2PROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 766 – 812 | G-patchPROSITE-ProRule annotationAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 6 – 75 | Arg-richAdd BLAST | 70 | |
Compositional biasi | 478 – 513 | Tyr-richAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the RBM5/RBM10 family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 186 – 215 | RanBP2-typePROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 671 – 696 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
GeneTreei | ENSGT00940000156617 |
HOGENOMi | CLU_010527_0_0_1 |
InParanoidi | A4IGK4 |
OMAi | YNPDDKL |
OrthoDBi | 786674at2759 |
Family and domain databases
CDDi | cd12752, RRM1_RBM5, 1 hit cd12755, RRM2_RBM5, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR041591, OCRE IPR035979, RBD_domain_sf IPR033094, RBM5 IPR034991, RBM5_RRM1 IPR034993, RBM5_RRM2 IPR000504, RRM_dom IPR013087, Znf_C2H2_type IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR13948:SF21, PTHR13948:SF21, 1 hit |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF17780, OCRE, 1 hit PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00360, RRM, 2 hits SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54928, SSF54928, 2 hits SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50102, RRM, 2 hits PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
A4IGK4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSDKRVSRS ERSGRYGSAF DRDDRDDRDT RSRRRDSEYK RYRDERSSER
60 70 80 90 100
YDDYRDYDSP ERDRMRDRER RNSDRSEDGY HSDGDYMDHD YRQDYYMDEK
110 120 130 140 150
ESKTIMLRGL PININENDIR ELVESFEGPQ PADVRLMKRK TGLSRGFAFV
160 170 180 190 200
EFYHLQDATR WMEANQKKLV IQGKTIAMHY SNPRPKFEDW LCNKCGLYNF
210 220 230 240 250
RRRLKCFRCG AAKAESDLEA PSGSSDAPQS TDYYSDSGYV SSAIILRNIG
260 270 280 290 300
PHTVVDSILS ALAPYVSLVV SNIRLIKDKQ TQQNRGFAFV QLPSTLEASQ
310 320 330 340 350
LLQILQTLHP PLKIDGKTVG VDFAKSARKD LVLPDGHRVS AFSVASTAIA
360 370 380 390 400
AAQWSSTQQA QQSGEGGEYA YLQPGQEGYA NYGQCSQDYQ PFYQAQTGAA
410 420 430 440 450
EQSTAPQAEG SAPVPATTSA VVCQSPQMYQ QPGSPTQSGT STAANTTPAS
460 470 480 490 500
TTSTTEEAAP PNAVIPGVKY SVPDTSTYQY DESSGYYYDP QTGLYYDPNS
510 520 530 540 550
QYYYNSLTQQ YLYWDGEKQT YLPAADGAGQ SGAQPNGANA GSSKEGKEKK
560 570 580 590 600
EKPKSKTAQQ IAKDMERWAK SLNKQKENFK NSFQPLSARD EERKESAAAD
610 620 630 640 650
AGFALFEKKQ GALLERQFMP DMMMMVNTEE EEKPPNKALV AAYSGDSDNE
660 670 680 690 700
EESERLLGAV DEEKLLDWKK LACLLCRRQF PNKDALTRHQ QLSDLHKQNL
710 720 730 740 750
EVYRRSKMSE QELEALELKE REAKYRDRAA ERREKYGIPE PPEPKRKRFD
760 770 780 790 800
PTVVNYEQPT KDGIDNSNIG NKMLQAMGWK EGSGLGRKSQ GITAPIQAQV
810 820 830
RMRGAGLGAK GSSYGVNTSD SYKDAVRKAM FARFSEME
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8R3J5 | A0A6I8R3J5_XENTR | RNA-binding protein 5 | rbm5 | 760 | Annotation score: | ||
A0A6I8SJ93 | A0A6I8SJ93_XENTR | RNA-binding protein 5 | rbm5 | 825 | Annotation score: | ||
A0A6I8SW00 | A0A6I8SW00_XENTR | RNA-binding protein 5 | rbm5 | 802 | Annotation score: | ||
A0A6I8RQN8 | A0A6I8RQN8_XENTR | RNA-binding protein 5 | rbm5 | 693 | Annotation score: | ||
A0A6I8R113 | A0A6I8R113_XENTR | RNA-binding protein 5 | rbm5 | 649 | Annotation score: | ||
A0A6I8RRG0 | A0A6I8RRG0_XENTR | RNA-binding protein 5 | rbm5 | 724 | Annotation score: | ||
A0A6I8QLM1 | A0A6I8QLM1_XENTR | RNA-binding protein 5 | rbm5 | 728 | Annotation score: | ||
A0A6I8SZZ9 | A0A6I8SZZ9_XENTR | RNA-binding protein 5 | rbm5 | 818 | Annotation score: | ||
A0A5S6L414 | A0A5S6L414_XENTR | Beta-lactamase-like protein 2 | lactb2 rbm5 | 297 | Annotation score: | ||
F6ZLH2 | F6ZLH2_XENTR | Beta-lactamase-like protein 2 | lactb2 | 317 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | C → S in CAJ81574 (Ref. 1) Curated | 1 | |
Sequence conflicti | 237 – 243 | SGYVSSA → T in CAJ81574 (Ref. 1) Curated | 7 | |
Sequence conflicti | 610 | Missing in CAJ81574 (Ref. 1) Curated | 1 | |
Sequence conflicti | 659 | A → V in CAJ81574 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR855749 mRNA Translation: CAJ81574.1 BC135140 mRNA Translation: AAI35141.1 |
RefSeqi | NP_001017278.1, NM_001017278.2 XP_012820244.1, XM_012964790.2 |
Genome annotation databases
Ensembli | ENSXETT00000015911; ENSXETP00000015911; ENSXETG00000007303 |
GeneIDi | 550032 |
KEGGi | xtr:550032 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR855749 mRNA Translation: CAJ81574.1 BC135140 mRNA Translation: AAI35141.1 |
RefSeqi | NP_001017278.1, NM_001017278.2 XP_012820244.1, XM_012964790.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | A4IGK4 |
Genome annotation databases
Ensembli | ENSXETT00000015911; ENSXETP00000015911; ENSXETG00000007303 |
GeneIDi | 550032 |
KEGGi | xtr:550032 |
Organism-specific databases
CTDi | 10181 |
Xenbasei | XB-GENE-494987, rbm5 |
Phylogenomic databases
GeneTreei | ENSGT00940000156617 |
HOGENOMi | CLU_010527_0_0_1 |
InParanoidi | A4IGK4 |
OMAi | YNPDDKL |
OrthoDBi | 786674at2759 |
Enzyme and pathway databases
Reactomei | R-XTR-72163, mRNA Splicing - Major Pathway |
Gene expression databases
Bgeei | ENSXETG00000007303, Expressed in brain and 22 other tissues |
Family and domain databases
CDDi | cd12752, RRM1_RBM5, 1 hit cd12755, RRM2_RBM5, 1 hit |
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR000467, G_patch_dom IPR012677, Nucleotide-bd_a/b_plait_sf IPR041591, OCRE IPR035979, RBD_domain_sf IPR033094, RBM5 IPR034991, RBM5_RRM1 IPR034993, RBM5_RRM2 IPR000504, RRM_dom IPR013087, Znf_C2H2_type IPR001876, Znf_RanBP2 IPR036443, Znf_RanBP2_sf |
PANTHERi | PTHR13948:SF21, PTHR13948:SF21, 1 hit |
Pfami | View protein in Pfam PF01585, G-patch, 1 hit PF17780, OCRE, 1 hit PF00076, RRM_1, 1 hit PF00641, zf-RanBP, 1 hit |
SMARTi | View protein in SMART SM00443, G_patch, 1 hit SM00360, RRM, 2 hits SM00547, ZnF_RBZ, 1 hit |
SUPFAMi | SSF54928, SSF54928, 2 hits SSF90209, SSF90209, 1 hit |
PROSITEi | View protein in PROSITE PS50174, G_PATCH, 1 hit PS50102, RRM, 2 hits PS01358, ZF_RANBP2_1, 1 hit PS50199, ZF_RANBP2_2, 1 hit PS50157, ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM5_XENTR | |
Accessioni | A4IGK4Primary (citable) accession number: A4IGK4 Secondary accession number(s): Q28D22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families