UniProtKB - A4IFU2 (A4IFU2_BOVIN)
Protein
Ras-related protein Rap-2
Gene
RAP2B
Organism
Bos taurus (Bovine)
Status
Functioni
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.UniRule annotation
Catalytic activityi
- EC:3.6.5.2ARBA annotation
GO - Molecular functioni
- GDP binding Source: Ensembl
- GTPase activity Source: UniProtKB-UniRule
- GTP binding Source: UniProtKB-UniRule
- protein domain specific binding Source: Ensembl
GO - Biological processi
- negative regulation of cell migration Source: Ensembl
- platelet aggregation Source: Ensembl
- positive regulation of protein autophosphorylation Source: UniProtKB-UniRule
- Rap protein signal transduction Source: UniProtKB-UniRule
- regulation of protein tyrosine kinase activity Source: Ensembl
Keywordsi
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rap-2UniRule annotation |
Gene namesi | Name:RAP2BImported |
Organismi | Bos taurus (Bovine)Imported |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Lipid-anchor ARBA annotation; Cytoplasmic side ARBA annotation
- Recycling endosome membrane UniRule annotationARBA annotation; Lipid-anchor UniRule annotationARBA annotation; Cytoplasmic side UniRule annotationARBA annotation
Cytosol
- cytosol Source: Ensembl
Endosome
- recycling endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- bicellular tight junction Source: Ensembl
- cell-cell contact zone Source: Ensembl
- membrane raft Source: Ensembl
Keywords - Cellular componenti
EndosomeUniRule annotationARBA annotation, MembraneUniRule annotationPTM / Processingi
Post-translational modificationi
Palmitoylated.UniRule annotation
Keywords - PTMi
Lipoprotein, MethylationUniRule annotation, PalmitateUniRule annotationARBA annotation, PrenylationUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSBTAG00000016961, Expressed in spleen and 19 other tissues |
Interactioni
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000052927 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160283 |
HOGENOMi | CLU_041217_9_8_1 |
OMAi | YGHINEV |
OrthoDBi | 1353024at2759 |
TreeFami | TF313014 |
Family and domain databases
CDDi | cd04176, Rap2, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041840, Rap2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
i Sequence
Sequence statusi: Complete.
A4IFU2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MREYKVVVLG SGGVGKSALT VQFVTGSFIE KYDPTIEDFY RKEIEVDSSP
60 70 80 90 100
SVLEILDTAG TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI
110 120 130 140 150
IRVKRYERVP MILVGNKVDL EGEREVSFGE GKALAEEWSC PFMETSAKNK
160 170 180
ASVDELFAEI VRQMNYAAQP NGDEGCCSAC VIL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC134764 mRNA Translation: AAI34765.1 BC151263 mRNA Translation: AAI51264.1 |
RefSeqi | NP_001096001.1, NM_001102531.1 |
Genome annotation databases
Ensembli | ENSBTAT00000083623; ENSBTAP00000071515; ENSBTAG00000055257 |
GeneIDi | 784133 |
KEGGi | bta:784133 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC134764 mRNA Translation: AAI34765.1 BC151263 mRNA Translation: AAI51264.1 |
RefSeqi | NP_001096001.1, NM_001102531.1 |
3D structure databases
SMRi | A4IFU2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000052927 |
Genome annotation databases
Ensembli | ENSBTAT00000083623; ENSBTAP00000071515; ENSBTAG00000055257 |
GeneIDi | 784133 |
KEGGi | bta:784133 |
Organism-specific databases
CTDi | 5912 |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160283 |
HOGENOMi | CLU_041217_9_8_1 |
OMAi | YGHINEV |
OrthoDBi | 1353024at2759 |
TreeFami | TF313014 |
Enzyme and pathway databases
Reactomei | R-BTA-6798695, Neutrophil degranulation |
Gene expression databases
Bgeei | ENSBTAG00000016961, Expressed in spleen and 19 other tissues |
Family and domain databases
CDDi | cd04176, Rap2, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR041840, Rap2 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4IFU2_BOVIN | |
Accessioni | A4IFU2Primary (citable) accession number: A4IFU2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |