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Protein

Fibroblast growth factor receptor

Gene

FGFR1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei621Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-109704 PI3K Cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-190370 FGFR1b ligand binding and activation
R-BTA-190373 FGFR1c ligand binding and activation
R-BTA-190374 FGFR1c and Klotho ligand binding and activation
R-BTA-445144 Signal transduction by L1
R-BTA-5654219 Phospholipase C-mediated cascade: FGFR1
R-BTA-5654687 Downstream signaling of activated FGFR1
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654689 PI-3K cascade:FGFR1
R-BTA-5654693 FRS-mediated FGFR1 signaling
R-BTA-5654700 FRS-mediated FGFR2 signaling
R-BTA-5654706 FRS-mediated FGFR3 signaling
R-BTA-5654712 FRS-mediated FGFR4 signaling
R-BTA-5654726 Negative regulation of FGFR1 signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:FGFR1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Organism-specific databases

VGNCiVGNC:50179 FGFR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei375 – 395HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501408367322 – 820Fibroblast growth factor receptorSequence analysisAdd BLAST799

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000015457 Expressed in 9 organ(s), highest expression level in lung

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020550

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 119Ig-likeInterPro annotationAdd BLAST95
Domaini156 – 244Ig-likeInterPro annotationAdd BLAST89
Domaini253 – 355Ig-likeInterPro annotationAdd BLAST103
Domaini476 – 765Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000263410
HOVERGENiHBG000345
KOiK04362
OMAiSVIVYKM
OrthoDBiEOG091G0CQZ
TreeFamiTF316307

Family and domain databases

CDDicd05098 PTKc_FGFR1, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR028174 FGF_rcpt_1
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

A4IFL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWSRKCLLFW AVLVTATLCT AKPAPTLPEQ AQPWGAPVEV ESLLVHPGDL
60 70 80 90 100
LQLRCRLRDD VQSINWLRDG VQLADSNRTR ITGEEVEVRG SVPADSGLYA
110 120 130 140 150
CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA
160 170 180 190 200
PYWTSPEKME KKLHAVPAAK TVKFKCPSSG TPNPTLRWLK NGKEFKPDHR
210 220 230 240 250
IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT YQLDVVERSP
260 270 280 290 300
HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP
310 320 330 340 350
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH
360 370 380 390 400
SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIIYKMKSG
410 420 430 440 450
TKKSDFHSQM AVHKLAKSIP LRRQVTVSAD SSASMNSGVL LVRPSRLSSS
460 470 480 490 500
GTPMLAGVSE YELPEDPRWE LPRDRLVLGK PLGEGCFGQV VLAEAIGLDK
510 520 530 540 550
DRPNRVTKVA VKMLKSDATE KDLSDLISEM EMMKMIGKHK NIINLLGACT
560 570 580 590 600
QDGPLYVIVE YASKGNLREY LQARRPPGLE YCYNPSHHPE EQLSSKDLVS
610 620 630 640 650
CAYQVARGME YLASKKCIHR DLAARNVLVT EDNVMKIADF GLARDIHHID
660 670 680 690 700
YYKKTTNGRL PVKWMAPEAL FDRIYTHQSD VWSFGVLLWE IFTLGGSPYP
710 720 730 740 750
GVPVEELFKL LKEGHRMDKP SNCTNELYMM MRDCWHAVPS QRPTFKQLVE
760 770 780 790 800
DLDRIVALTS NQEYLDLSMP LDQYSPSFPD TRSSTCSSGE DSVFSHEPLP
810 820
EEPCLPRHPA QLANGGLKRR
Length:820
Mass (Da):91,493
Last modified:January 15, 2008 - v2
Checksum:i7E963D04CBDCA117
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02060851 Genomic DNA No translation available.
DAAA02060852 Genomic DNA No translation available.
BC134637 mRNA Translation: AAI34638.2
RefSeqiNP_001103677.1, NM_001110207.1
XP_005226151.1, XM_005226094.3
UniGeneiBt.32941

Genome annotation databases

EnsembliENSBTAT00000020550; ENSBTAP00000020550; ENSBTAG00000015457
GeneIDi281768
KEGGibta:281768

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02060851 Genomic DNA No translation available.
DAAA02060852 Genomic DNA No translation available.
BC134637 mRNA Translation: AAI34638.2
RefSeqiNP_001103677.1, NM_001110207.1
XP_005226151.1, XM_005226094.3
UniGeneiBt.32941

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020550

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020550; ENSBTAP00000020550; ENSBTAG00000015457
GeneIDi281768
KEGGibta:281768

Organism-specific databases

CTDi2260
VGNCiVGNC:50179 FGFR1

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
HOGENOMiHOG000263410
HOVERGENiHBG000345
KOiK04362
OMAiSVIVYKM
OrthoDBiEOG091G0CQZ
TreeFamiTF316307

Enzyme and pathway databases

ReactomeiR-BTA-109704 PI3K Cascade
R-BTA-1257604 PIP3 activates AKT signaling
R-BTA-190370 FGFR1b ligand binding and activation
R-BTA-190373 FGFR1c ligand binding and activation
R-BTA-190374 FGFR1c and Klotho ligand binding and activation
R-BTA-445144 Signal transduction by L1
R-BTA-5654219 Phospholipase C-mediated cascade: FGFR1
R-BTA-5654687 Downstream signaling of activated FGFR1
R-BTA-5654688 SHC-mediated cascade:FGFR1
R-BTA-5654689 PI-3K cascade:FGFR1
R-BTA-5654693 FRS-mediated FGFR1 signaling
R-BTA-5654700 FRS-mediated FGFR2 signaling
R-BTA-5654706 FRS-mediated FGFR3 signaling
R-BTA-5654712 FRS-mediated FGFR4 signaling
R-BTA-5654726 Negative regulation of FGFR1 signaling
R-BTA-5673001 RAF/MAP kinase cascade
R-BTA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Gene expression databases

BgeeiENSBTAG00000015457 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

CDDicd05098 PTKc_FGFR1, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR028174 FGF_rcpt_1
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA4IFL5_BOVIN
AccessioniPrimary (citable) accession number: A4IFL5
Secondary accession number(s): F1MKA3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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