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UniProtKB - A4IF30 (S35F4_HUMAN)
Protein
Solute carrier family 35 member F4
Gene
SLC35F4
Organism
Homo sapiens (Human)
Status
Functioni
Putative solute transporter.
CuratedGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | A4IF30 |
Protein family/group databases
TCDBi | 2.A.7.24.14, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 35 member F4 |
Gene namesi | Name:SLC35F4 Synonyms:C14orf36 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19845, SLC35F4 |
neXtProti | NX_A4IF30 |
VEuPathDBi | HostDB:ENSG00000151812 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 160 – 180 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 248 – 266 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 277 – 297 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 301 – 321 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 330 – 350 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 365 – 385 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 395 – 417 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 419 – 441 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 450 – 470 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 341880 |
OpenTargetsi | ENSG00000151812 |
PharmGKBi | PA134959551 |
Miscellaneous databases
Pharosi | A4IF30, Tdark |
Genetic variation databases
BioMutai | SLC35F4 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311965 | 1 – 521 | Solute carrier family 35 member F4Add BLAST | 521 |
Proteomic databases
PaxDbi | A4IF30 |
PeptideAtlasi | A4IF30 |
PRIDEi | A4IF30 |
PTM databases
iPTMneti | A4IF30 |
PhosphoSitePlusi | A4IF30 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151812, Expressed in cerebellar hemisphere and 103 other tissues |
ExpressionAtlasi | A4IF30, baseline and differential |
Genevisiblei | A4IF30, HS |
Organism-specific databases
HPAi | ENSG00000151812, Tissue enhanced (brain, retina, seminal vesicle) |
Interactioni
Protein-protein interaction databases
IntActi | A4IF30, 1 interactor |
STRINGi | 9606.ENSP00000342518 |
Miscellaneous databases
RNActi | A4IF30, protein |
Structurei
3D structure databases
AlphaFoldDBi | A4IF30 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 261 – 321 | EamAAdd BLAST | 61 |
Sequence similaritiesi
Belongs to the SLC35F solute transporter family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4314, Eukaryota |
GeneTreei | ENSGT00390000008727 |
HOGENOMi | CLU_022280_0_1_1 |
InParanoidi | A4IF30 |
OrthoDBi | 639186at2759 |
PhylomeDBi | A4IF30 |
TreeFami | TF313798 |
Family and domain databases
InterProi | View protein in InterPro IPR009262, SLC35_F1/F2/F6 IPR026505, Solute_c_fam_35_mem_F3/F4 |
PANTHERi | PTHR19346, PTHR19346, 1 hit |
Pfami | View protein in Pfam PF06027, SLC35F, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A4IF30-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDELLLDLFH KLTSGRQLAA GNGLCGISHK EQEVWKPGHN ILVKMRKEDK
60 70 80 90 100
SLVWLIHSTL ARYTQVTNFL GTSRSSVTRC KPGANCPSSH SGISRQLSPL
110 120 130 140 150
SVTEDSSAPI LELQNQGSSG VCGHRVERQN RSADDGTQTH SENSSQENRI
160 170 180 190 200
KARCLSCTSM VLKGIWGLLI ILSVSSSWVG TTQIVKITYK NFYCPFFMTW
210 220 230 240 250
FSTNWNIMFF PVYYSGHLAT AQEKQSPMKK FRECSRIFGE DGLTLKLFLK
260 270 280 290 300
RTAPFSILWT LTNYLYLLAL KKLTATDVSA LFCCNKAFVF LLSWIVLKDR
310 320 330 340 350
FMGVRIVAAI MAITGIVMMA YADNFHADSI IGVAFAVGSA STSALYKVLF
360 370 380 390 400
KMFLGSANFG EAAHFVSTLG FFNLIFISFT PVILYFTKVE HWSSFAALPW
410 420 430 440 450
GCLCGMAGLW LAFNILVNVG VVLTYPILIS IGTVLSVPGN AAVDLLKQEV
460 470 480 490 500
IFNVVRLAAT IIICIGFLLM LLPEEWDEIT LRFINSLKEK KSEEHVDDVT
510 520
DPSIHLRGRG RANGTVSIPL A
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V4Z9 | G3V4Z9_HUMAN | Solute carrier family 35 member F4 | SLC35F4 | 485 | Annotation score: | ||
H0YJV4 | H0YJV4_HUMAN | Solute carrier family 35 member F4 | SLC35F4 | 46 | Annotation score: | ||
G3V2S4 | G3V2S4_HUMAN | Solute carrier family 35 member F4 | SLC35F4 | 151 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029669 | 1 – 159 | Missing in isoform 2. 1 PublicationAdd BLAST | 159 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136520 Genomic DNA No translation available. AL161804 Genomic DNA No translation available. BC101318 mRNA Translation: AAI01319.1 BC101320 mRNA Translation: AAI01321.1 BC101321 mRNA Translation: AAI01322.1 |
CCDSi | CCDS86392.1 [A4IF30-2] |
RefSeqi | NP_001193849.1, NM_001206920.1 NP_001293016.1, NM_001306087.1 XP_011535027.1, XM_011536725.1 XP_016876749.1, XM_017021260.1 [A4IF30-2] |
Genome annotation databases
Ensembli | ENST00000339762.10; ENSP00000342518.6; ENSG00000151812.15 ENST00000554729.5; ENSP00000451990.1; ENSG00000151812.15 [A4IF30-2] |
GeneIDi | 341880 |
KEGGi | hsa:341880 |
UCSCi | uc010apa.2, human [A4IF30-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136520 Genomic DNA No translation available. AL161804 Genomic DNA No translation available. BC101318 mRNA Translation: AAI01319.1 BC101320 mRNA Translation: AAI01321.1 BC101321 mRNA Translation: AAI01322.1 |
CCDSi | CCDS86392.1 [A4IF30-2] |
RefSeqi | NP_001193849.1, NM_001206920.1 NP_001293016.1, NM_001306087.1 XP_011535027.1, XM_011536725.1 XP_016876749.1, XM_017021260.1 [A4IF30-2] |
3D structure databases
AlphaFoldDBi | A4IF30 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | A4IF30, 1 interactor |
STRINGi | 9606.ENSP00000342518 |
Protein family/group databases
TCDBi | 2.A.7.24.14, the drug/metabolite transporter (dmt) superfamily |
PTM databases
iPTMneti | A4IF30 |
PhosphoSitePlusi | A4IF30 |
Genetic variation databases
BioMutai | SLC35F4 |
Proteomic databases
PaxDbi | A4IF30 |
PeptideAtlasi | A4IF30 |
PRIDEi | A4IF30 |
Protocols and materials databases
Antibodypediai | 50928, 24 antibodies from 9 providers |
DNASUi | 341880 |
Genome annotation databases
Ensembli | ENST00000339762.10; ENSP00000342518.6; ENSG00000151812.15 ENST00000554729.5; ENSP00000451990.1; ENSG00000151812.15 [A4IF30-2] |
GeneIDi | 341880 |
KEGGi | hsa:341880 |
UCSCi | uc010apa.2, human [A4IF30-1] |
Organism-specific databases
CTDi | 341880 |
DisGeNETi | 341880 |
GeneCardsi | SLC35F4 |
HGNCi | HGNC:19845, SLC35F4 |
HPAi | ENSG00000151812, Tissue enhanced (brain, retina, seminal vesicle) |
neXtProti | NX_A4IF30 |
OpenTargetsi | ENSG00000151812 |
PharmGKBi | PA134959551 |
VEuPathDBi | HostDB:ENSG00000151812 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4314, Eukaryota |
GeneTreei | ENSGT00390000008727 |
HOGENOMi | CLU_022280_0_1_1 |
InParanoidi | A4IF30 |
OrthoDBi | 639186at2759 |
PhylomeDBi | A4IF30 |
TreeFami | TF313798 |
Enzyme and pathway databases
PathwayCommonsi | A4IF30 |
Miscellaneous databases
BioGRID-ORCSi | 341880, 2 hits in 246 CRISPR screens |
ChiTaRSi | SLC35F4, human |
GenomeRNAii | 341880 |
Pharosi | A4IF30, Tdark |
PROi | PR:A4IF30 |
RNActi | A4IF30, protein |
Gene expression databases
Bgeei | ENSG00000151812, Expressed in cerebellar hemisphere and 103 other tissues |
ExpressionAtlasi | A4IF30, baseline and differential |
Genevisiblei | A4IF30, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009262, SLC35_F1/F2/F6 IPR026505, Solute_c_fam_35_mem_F3/F4 |
PANTHERi | PTHR19346, PTHR19346, 1 hit |
Pfami | View protein in Pfam PF06027, SLC35F, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35F4_HUMAN | |
Accessioni | A4IF30Primary (citable) accession number: A4IF30 Secondary accession number(s): A6NDQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | December 4, 2007 | |
Last modified: | May 25, 2022 | |
This is version 99 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families