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Entry version 73 (05 Jun 2019)
Sequence version 2 (05 Apr 2011)
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Protein
Submitted name:

Calpain protease-like protein

Gene

LINF_330028900

Organism
Leishmania infantum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei402PROSITE-ProRule annotation1
Active sitei571PROSITE-ProRule annotation1
Active sitei591PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.029

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calpain protease-like proteinImported (EC:3.4.22.-Imported)
Submitted name:
Calpain_protease-like_proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LINF_330028900Imported, LINJ_33_2130Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania infantumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5671 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008153 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 33

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini385 – 650Calpain catalyticInterPro annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni73 – 133DisorderedSequence analysisAdd BLAST61
Regioni151 – 226DisorderedSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi73 – 88PolarSequence analysisAdd BLAST16
Compositional biasi151 – 168PolarSequence analysisAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4I963

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 1 hit
PF04212 MIT, 1 hit
PF00648 Peptidase_C2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF116846 SSF116846, 1 hit
SSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4I963-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSSFPAEAS MWMQNAVHLD TDHKYVEAEE CYTKAIFLFR QALSDPNMAD
60 70 80 90 100
TERQKLLSYM SDVAKRIQRL RALNRTSQSA NSPEPSVSPS GPLGRRASAR
110 120 130 140 150
QASEHTPPRG SDAAATAFGA RNPRGKDGKK APAGVENDLK VLDAIQVNQT
160 170 180 190 200
DPFQASNSSP SPSAASSMSG KRALPVASPT PSPPSAPPCK PTCGSDGVPD
210 220 230 240 250
GGKPGGSSAE PPALPTPPPP GSSQRLFGVA SHFAPRTSEM VYKAIGIAIQ
260 270 280 290 300
LSQQGELKRA VDVLQHAYSR GSRERNNPGN FKEIGETLKL MRQKYYAKHL
310 320 330 340 350
PRFLQDNPIL PSEMELLRKS GITSTILLPL WDDVHEGYGA ENIFMPCEGV
360 370 380 390 400
WEDAFTPKLC QRQISSGAVL MHFSGYRQAG LDYTIVREAD PLHIRQSVVG
410 420 430 440 450
DCSLVCSLMI CASYQKRFPN AKIISNVIYP QDRDGNPILN PKGKYCVKML
460 470 480 490 500
INGITRMVTV DDRLPVNPQS RRFLCTSSTD PSELWVSIME KAFVKVCGGS
510 520 530 540 550
YNFPGSVSYA DLYKLSGWLP DSTAFGKPEF DREFQWRRLY QNFKAGALLF
560 570 580 590 600
TVSTPVEMPA ADEALGLAAG HAYAVLDMQE VGKERVMLLR NPWGKQEWNG
610 620 630 640 650
KYGRRDTSEA SVAVRAAFDL KREEEDMGVF CIAYDDVVRC FDNCSLSWNP
660 670 680 690 700
YMLYRTPEGR PRRPVRIACH GAFDYTLSTA LSPQLHIGVV DAPKRTRMHL
710 720 730 740 750
ILSRHITDVS EFGRQYEKDD DTTPYLALKV YDVTDYPSVA QHLGGHCSLE
760 770 780 790 800
MCYCRRLASN SDFKNSIEPL NDVIYRASSA RTFSFDCPAG SSNLVVVVSR
810 820 830 840 850
TASKARQPFN FTVTLHTELE QMRLPRLQGN YGSGAEDKNS LLASANANAG
860 870 880 890 900
NPCAGVYMHM IPTSSLKFTT RLSGAWVKGK TCGGRTDAAT YVFNPQYRLH
910 920 930 940 950
LDQPSHVSLR LAVAGCEVPC SIQMIKPMSS NKYEENGGSG GIKRKMTDFD
960 970 980 990 1000
GRVGNGAKAG ELVLESARYA FGGAVLDSAL PFCVCYDRYR ALGKLHWREA
1010 1020 1030 1040 1050
KKVLVNVTAP NRTPESFIVY DLGDTDTVAV LLLNAIKKGC AASPRDAHFS
1060 1070 1080 1090 1100
VNGKPITLEA TIASLFQLAS SLGGESLASG GDGATTAKSV TVALALDGKA
1110 1120 1130 1140 1150
ASIESASSPP VRKLKEVMND IVSDVLKCSS QFSSYVPRLT HLARQANSAL
1160 1170 1180 1190 1200
TGASDADVRA YILELAAYLA DYVKRCASAV RSAQTPQALL PLLPAGDYTV
1210 1220 1230 1240 1250
IPSLWEKGKP GSFELTVETS QPHKTSAIPK EGHNMQETLV RGALRPVAVC
1260 1270 1280 1290 1300
LGTSLMKPRA VLSMRDPFFE NSKVQVLCPA RSVFMSRLFV LVDMVDAEAK
1310 1320 1330 1340 1350
GQPAKAPATN LSLFRVHNAS SMELVCASDE YSHGGVSTPP VELEAKTQYL
1360 1370
LVVSAKESVA DKFLLRIYTS GSCTAQLAS
Length:1,379
Mass (Da):150,195
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10D4FF8F1C290F08
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR796465 Genomic DNA Translation: CAM71365.2
UINB01000033 Genomic DNA Translation: SUZ45222.1

NCBI Reference Sequences

More...
RefSeqi
XP_001468282.2, XM_001468245.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAM71365; CAM71365; LINJ_33_2130

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LinJ.33.2130:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5072357

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lif:LINJ_33_2130

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796465 Genomic DNA Translation: CAM71365.2
UINB01000033 Genomic DNA Translation: SUZ45222.1
RefSeqiXP_001468282.2, XM_001468245.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC02.029

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAM71365; CAM71365; LINJ_33_2130
GeneDBiLinJ.33.2130:pep
GeneIDi5072357
KEGGilif:LINJ_33_2130

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
InParanoidiA4I963

Family and domain databases

InterProiView protein in InterPro
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF04212 MIT, 1 hit
PF00648 Peptidase_C2, 1 hit
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit
SSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4I963_LEIIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4I963
Secondary accession number(s): A0A2K4Z3Z5, A0A381MSC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: April 5, 2011
Last modified: June 5, 2019
This is version 73 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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