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UniProtKB - A4I5V0 (A4I5V0_LEIIN)

Entry version 58 (25 May 2022)
Sequence version 1 (01 May 2007)
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Protein

Afi1 domain-containing protein

Gene

LINJ_30_2730

Organism
Leishmania infantum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Afi1 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LINJ_30_2730Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania infantumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5671 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008153 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 30

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		TriTrypDB:LINF_300032500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500266943522 – 943Afi1 domain-containing proteinSequence analysisAdd BLAST922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		A4I5V0

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 88Afi1InterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni289 – 308DisorderedSequence analysisAdd BLAST20
Regioni316 – 423DisorderedSequence analysisAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi316 – 342Polar residuesSequence analysisAdd BLAST27
Compositional biasi382 – 413Polar residuesSequence analysisAdd BLAST32

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RSJE, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A4I5V0

Identification of Orthologs from Complete Genome Data

More...OMAi		RILKRCY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012860, Afi1_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07792, Afi1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4I5V0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKSSATAVS APLLATSVIV AEFDIDTGAC LRACYPPVPT SPSTALLSSI 
        60         70         80         90        100
ESGAPPGIAG HTEYFANVML PDGAEKVNVT RTVFVVNRPQ PPLYLRFPVY 
       110        120        130        140        150
RFARASASTG SSDTQAAWER RPGEETARYV PEILLINATT EEVSLRYKDT 
       160        170        180        190        200
EIEAPCAVPM ENISSLPNIP ADVVRFSKQL EAMLKNEATL DRSYSVSFAS 
       210        220        230        240        250
GGDTNTMDAG AAATSGAGGR GVGLGGASTA VGGGGGGSSI GDYTFVLVDY 
       260        270        280        290        300
TTAAVARQEG YLMKVSNFDR LLKTMTTLLQ RKKTAAAAAA SGAPRANNSG 
       310        320        330        340        350
DASAAAASES IVTPLTEAGS LSTMNSTRKE QPGSSANDTF KTTVHDIRLP 
       360        370        380        390        400
FMPDMYGGRH PGLSGEGSPA SPEPRLAGGG GGADTQSTTS SMEQSGHLML 
       410        420        430        440        450
PRTDPTSSGD DSDADSVAGG HHVDASSTAA VAAAATEKGG QGASTEASRP 
       460        470        480        490        500
VLFGLCAVVS KRDSTARRGG ITKSVAVLGP SLVWLEPFFP ILVAAAQYCC 
       510        520        530        540        550
DVNGTDKSAV RELQRILKRC YDSVNNAAGM VAAGRAKVDQ LTAEISKYCT 
       560        570        580        590        600
LSSGQQAYVY YNDAPFGNTI KAKIPLSPES NDIVFTRYSL ESLIETLGPS 
       610        620        630        640        650
SLHLLLGILT EKKILILSRK GEAADVCEAA LSLGIIGNML DRDFMARKVF 
       660        670        680        690        700
PYVSVSSVNY FMQVPGYIVG TLNPIFDNVN PWGWDLLCDL DNKSVITAAE 
       710        720        730        740        750
RLQRKTTGLS SSAGGNWSAA TAGLANAVGV GGGNDAEALR NFPAPLQQLY 
       760        770        780        790        800
KQLLNTIYHL RALRIGAVER SHRLRLMVED FVYTVVLVGY VNGASVSVPN 
       810        820        830        840        850
ALYSTFAHRS LSALRSEMML TSMMDNIRTH ILHRGENPAL LLHCVALRHC 
       860        870        880        890        900
AWGETPVQRT LQALLDLLNT ACDLKLFLRR MPLAVGGLNA VGMQLTSPSA 
       910        920        930        940 
EARAAAAALL ARLELVPEGK AAIASMNNFF VMIYESGMTG AGR
Length:943
Mass (Da):99,415
Last modified:May 1, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0759E706CB88209B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
FR796462 Genomic DNA Translation: CAM70172.1

NCBI Reference Sequences

More...RefSeqi		XP_001467119.1, XM_001467082.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5071165

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		lif:LINJ_30_2730

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796462 Genomic DNA Translation: CAM70172.1
RefSeqiXP_001467119.1, XM_001467082.1

3D structure databases

AlphaFoldDBiA4I5V0
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Genome annotation databases

GeneIDi5071165
KEGGilif:LINJ_30_2730

Organism-specific databases

VEuPathDBiTriTrypDB:LINF_300032500

Phylogenomic databases

eggNOGiENOG502RSJE, Eukaryota
InParanoidiA4I5V0
OMAiRILKRCY

Family and domain databases

InterProiView protein in InterPro
IPR012860, Afi1_N
PfamiView protein in Pfam
PF07792, Afi1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4I5V0_LEIIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4I5V0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 25, 2022
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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