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Entry version 54 (05 Jun 2019)
Sequence version 1 (01 May 2007)
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Protein
Submitted name:

C2_domain_in_Dock180_and_Zizimin_proteins_-_putative

Gene

LINF_290006000

Organism
Leishmania infantum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
C2_domain_in_Dock180_and_Zizimin_proteins_-_putativeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LINF_290006000Imported, LINJ_29_0110Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania infantumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5671 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008153 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 29

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5671.XP_001466517.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini996 – 1179DHR-1InterPro annotationAdd BLAST184

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 155DisorderedSequence analysisAdd BLAST140
Regioni169 – 404DisorderedSequence analysisAdd BLAST236
Regioni435 – 510DisorderedSequence analysisAdd BLAST76
Regioni1359 – 1390DisorderedSequence analysisAdd BLAST32
Regioni2156 – 2181DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi43 – 74PolyampholyteSequence analysisAdd BLAST32
Compositional biasi115 – 155PolyampholyteSequence analysisAdd BLAST41
Compositional biasi436 – 460PolarSequence analysisAdd BLAST25
Compositional biasi463 – 477PolyampholyteSequence analysisAdd BLAST15
Compositional biasi488 – 502PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1367 – 1382PolarSequence analysisAdd BLAST16
Compositional biasi2156 – 2170PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J56E Eukaryota
ENOG410ZN26 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4I448

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYRPCCE

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027007 DHR-1_domain
IPR026791 DOCK
IPR010703 DOCK_C

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4I448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTDNDIERQ IMMEMEAEIS RSQGNRRDPY TNPPPFELSF IEDDPMEAAR
60 70 80 90 100
KAEVDRIQRE IEERLRRKQQ QKQRDSLELS PNCPANEGEM SAVYDSLQQP
110 120 130 140 150
QNASWPVGAH DRHVVRASLS SESENREKAE EASRLRDDEA AMTRRETDEE
160 170 180 190 200
ARIDMEVQVR RSAEIQALRE AEEQARREAE EQARRVAEEQ ARREAEEQAR
210 220 230 240 250
REAEEQARRV AEEQARREAE EQARRVAEEQ ARRVAEEQAR REAEEQARRV
260 270 280 290 300
AEEQARRVAE EQARLVAEEQ ARREAEEQAR REAEEQARRV AEEQARRVAE
310 320 330 340 350
EQARRVAEEQ ARREAEEQAR RVAEEQARRE AEEQARRVAE EQARRVAEEQ
360 370 380 390 400
ARREAEEQAR RVAEEQARRV AEEQARREAE EQARREAEEQ ARREAEEQAG
410 420 430 440 450
GLEEVLREAR AVVMGEFSEK LKQHSAVAAF VSDTDEKPVN SASATHRGDA
460 470 480 490 500
RWQNEYTEQG GTGADAEEEH GVQQHDSRCC RYRTSSPSVS DRDMRSERST
510 520 530 540 550
NSKDSASETV SRYSLSTLEA IRNDNGILSR TEEEVYYVPR VTKEAPFESF
560 570 580 590 600
EEALSAELKA HGLTEDAIRR SCIEVHRYGT IRESGKCLFP PREVTGEVPA
610 620 630 640 650
HGKVQLGFFS AKQTIIALQR PLRKPNADRE RPCEPGERSL STLKCYFESE
660 670 680 690 700
VLSDHTLTVD DEDYPHNAPT ERLLTKAQLM RGDNAMVRKA VSQISYGDPI
710 720 730 740 750
QVWERAQQNS TAADEAATES TAANLWVSDI DTRKPVPAMR TFTGGFVYCI
760 770 780 790 800
KATKISNRVI ELHGASTDPL VIAAALYSWT ERQKVKVSET FYFDSELDIF
810 820 830 840 850
YPQKERSELA KKNQVVAFVP NEFKGTLHLV MRVYRPCCEE YDTYVDLYSR
860 870 880 890 900
ADRYKQIHVA PMKQETLLLT QVSDVLEELG WNSVPLQDEA NHLLPRVAVD
910 920 930 940 950
RLYRKAFSNE DVFKVMKDER WRGAQKALPV DMVFSISDLS RHEVAFPSDH
960 970 980 990 1000
PETPPEENES KVSLLDPDLP GARPVIYRYS PCCIPILNSG YFTTYNNVYY
1010 1020 1030 1040 1050
FSVSRLKVMY AGFVRSIPAS HHTYVFQLCV KDKDDGLSEE GAIRCIYGRG
1060 1070 1080 1090 1100
LSNLSMETTA WSSSVHNSND MVLSDEFKLQ LPLNLSDRHH IFMTLYATCQ
1110 1120 1130 1140 1150
RKMPPTPGQP RMFKIGYAAV PLMMNGVVQV RDSIDIKFVS YDQAAVAAAG
1160 1170 1180 1190 1200
GYLTSFAEAP VNFLLNNGEG VVKASSQTKT TVHASNRVIA SVFQQCPSSI
1210 1220 1230 1240 1250
AEMRKNDKVL DECGALQKLP AMEVDPHRNV ISLIAQLPLA EILAFYPFLT
1260 1270 1280 1290 1300
AYAFSLIGSG SATVSLANRI HMLDVLLGIT SKAQQYDTSA HTIRRRHNSE
1310 1320 1330 1340 1350
GLTPQVFAKT SVGSILYHFL SNDTLYEGAK CEYKRRLYSG MVEAWLNLLK
1360 1370 1380 1390 1400
MVAQQPNGIG ADSAKEKSGT SAPSSSPASP ASLARGSKAP PPARSILREM
1410 1420 1430 1440 1450
SNLSWFLFDT ILRSMYLWGA ENPTVPRQEL FHSSFYTAVA ELCIVALSQL
1460 1470 1480 1490 1500
STFDESQLVR HVAIFVRSLM HYADRGRVLM IYERIAAYFE EDGNFESLTN
1510 1520 1530 1540 1550
FLKYVLEDPD AIYLLLPSAG AARPVFLTRI VVHSFTILMI NPNRVTRSIA
1560 1570 1580 1590 1600
TDVLYSFLRR LANDSSTPSE NLTCIAAQLF ALVRNLGPHW KAITQPNDKI
1610 1620 1630 1640 1650
PIEVFQRDKQ QLSMTCLWIL YYTPRSTFRQ WLQEEVDGKV IAGMMQIVAE
1660 1670 1680 1690 1700
SQSTFRYTAA PASSSAAGPV AGVAKDAANE EVEERRAWEA RSTTFVTAIG
1710 1720 1730 1740 1750
TQMCSLFLNE IPSILRTVRD NNPNAAVFPF FVMLESVLNL GNSTISLQMS
1760 1770 1780 1790 1800
SAVMHEVVCK LFPEIISRKA RMGNGMVLLT FRLMSSCCQY VRSSASCTFL
1810 1820 1830 1840 1850
LMSQAFFSWK NSLSKIRSLT ANALVSVAES RVRDLRLAGR FIEFQFDELI
1860 1870 1880 1890 1900
ERAKVEEANY TAPSCDFASR YEDDSNAPGG DAQMKYRQKV EGQVMSVQRN
1910 1920 1930 1940 1950
LPISRYLLEK SNVPDQQPPR FSSDFTAMTA TVLSLFDDVL RLQMDDSMKF
1960 1970 1980 1990 2000
KEARATAYFE VFRNFLRQNA LKEALKWLYR LHDAHRANSD YLEAGMVLVF
2010 2020 2030 2040 2050
IAALCFRVTE VFYFVKGKDS KGARMPFEVL SHVFWHDYVR ILPEVDALLP
2060 2070 2080 2090 2100
ADTVYAIVSE LYTCPDDMCF SMEGQVKALK EAAEFQDKGQ YYEYSLQTID
2110 2120 2130 2140 2150
IANKYLMAVS DFKGSSVVHM AMSTWCTAIA EPKSKRHNSR YFFLWARMER
2160 2170 2180 2190 2200
HTLPKSRKEL HEDANDSKVG EKPRGLPNGN PIRRIYKMST ATTLEEFKNY
2210 2220 2230 2240 2250
ARSYVESLFF DTSLVLLTDD LTETLPALPE PDSKRKRVAA VHRQPNHCLV
2260 2270 2280 2290 2300
TVSEAQPYFA KGTRVPPDGF DRSMHISYFE NTVNVGSRDE VSDGRKLDLM
2310 2320 2330 2340 2350
TQRMSVNTYE LERSFPSTTS AIDIAKTHQV VLNPFETAEE MLNSRREAMN
2360 2370 2380 2390 2400
QAPVNDALIT VIRKALSPKE LPPGAYMKEV IAVMGDHPEV IHAVRALSTL
2410 2420 2430 2440 2450
ARAKLEACEK MEAMSKNPED YALVLKAVTD IECCLVAMQH PDENDHASSS

GM
Length:2,452
Mass (Da):277,735
Last modified:May 1, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBE5AF5ED443DB64
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR796461 Genomic DNA Translation: CAM69556.1
UINB01000029 Genomic DNA Translation: SUZ43509.1

NCBI Reference Sequences

More...
RefSeqi
XP_001466517.1, XM_001466480.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAM69556; CAM69556; LINJ_29_0110

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LinJ.29.0110:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5070549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lif:LINJ_29_0110

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796461 Genomic DNA Translation: CAM69556.1
UINB01000029 Genomic DNA Translation: SUZ43509.1
RefSeqiXP_001466517.1, XM_001466480.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi5671.XP_001466517.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAM69556; CAM69556; LINJ_29_0110
GeneDBiLinJ.29.0110:pep
GeneIDi5070549
KEGGilif:LINJ_29_0110

Phylogenomic databases

eggNOGiENOG410J56E Eukaryota
ENOG410ZN26 LUCA
InParanoidiA4I448
OMAiVYRPCCE

Family and domain databases

InterProiView protein in InterPro
IPR027007 DHR-1_domain
IPR026791 DOCK
IPR010703 DOCK_C
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4I448_LEIIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4I448
Secondary accession number(s): A0A2K4YZ69, A0A381MMP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: June 5, 2019
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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