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Entry version 70 (05 Jun 2019)
Sequence version 2 (05 Apr 2011)
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Protein
Submitted name:

Cysteine_peptidase_-_Clan_CA_-_family_C2_-_putative

Gene

LINF_200016800

Organism
Leishmania infantum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cysteine_peptidase_-_Clan_CA_-_family_C2_-_putativeImported
Submitted name:
Putative calpain-like cysteine peptidaseImported (EC:3.4.22.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LINF_200016800Imported, LINJ_20_1210Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania infantumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5671 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008153 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini514 – 827Calpain catalyticInterPro annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 278DisorderedSequence analysisAdd BLAST278

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 30PolyampholyteSequence analysisAdd BLAST15
Compositional biasi36 – 176AcidicSequence analysisAdd BLAST141
Compositional biasi185 – 200PolyampholyteSequence analysisAdd BLAST16
Compositional biasi215 – 241PolyampholyteSequence analysisAdd BLAST27

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4HYW1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00044 CysPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR015232 DUF1935
IPR013780 Glyco_hydro_b
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
IPR036310 Smp-1-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09149 DUF1935, 1 hit
PF00648 Peptidase_C2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101601 SSF101601, 1 hit
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4HYW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQDQLNDEA QWTEIEEEAP QERETPNTPD QAEDCNEAAP AEEQAEDCNE
60 70 80 90 100
AAPAEEQAED CNEAAPAEEQ AEDCSEAAPA EEQAEDCNEA APAEEQAEDC
110 120 130 140 150
NEAAPAEEQA EDCNEAAPAE EQAEDCNEAA PAEEQAEDCN EAAPAEEQAE
160 170 180 190 200
DCNEAAPVEE QAEDCNESEP AEEQAEGAAD GPDQRQDLGS EEKPEPPFEE
210 220 230 240 250
TQQAEECPED VVPLEASETQ EHETPGAEEA YEGERAEHLA QKSHSPQYYL
260 270 280 290 300
ADSEPQVIPQ QACEEEAPQE YPKEIGNNYD APQHAYEVVA PDNAHARSMP
310 320 330 340 350
APHAAAAATP PSAIVKPRTR NVKSVARWEA VEYDLRDGSD DEFELSTCMT
360 370 380 390 400
PVYEGEGEEG NEDASVFKHG EPDCKGEIMS CFDEPNLLYR IIDPKAKTWS
410 420 430 440 450
FYNDSLQYEM HVQFIFGKHS KLQPLENTTL RQNEEGQYVM EVVVYPTETE
460 470 480 490 500
MFLQGTVNGF TSKLRAVPLT EDYHNARRGI TEELVNNEVA AIQQVTSSDN
510 520 530 540 550
AEDVLQACID SGIPFVDPEF PPCQASLEAG ANKPFKPFAW ARPQACVPEE
560 570 580 590 600
MASQVRLFRA NVRPGCVDAG DLGDSWVICS VASVSEDPAR LMGMFRHPEG
610 620 630 640 650
KAAAQREHAV GAYRVTFNKN GWWRSVLVDS YLPVSGGKLK YAKSATDPAE
660 670 680 690 700
IWPAILEKAY AKLHGSYARI CSGDPLHALQ DMTGFSTMRF DESLTDDKAS
710 720 730 740 750
DQLFSDLVHG IAAGYTVICS TPGRGPHDKD QELCEAYAQV GLVTGCAYTI
760 770 780 790 800
LEAKHIENKD LRMVKVRNAW GRGVEWSGSW GNDDTKWDAN PDIAEECNFQ
810 820 830 840 850
KAANGMFWMS WKDARKYFNG GGVCFTHQPA YDYRMNCVFT EGVPSAVLEI
860 870 880 890 900
EVQSPTCFTF VISQDDKRCQ VNASEYKPVM ISIAEPVEGD MYKVVMNSSA
910 920 930 940 950
NGARPTSDKW MFLQARDVSL IHKLDAGKYI VVPRIMPSDD PVEPVPYVLG
960 970 980 990 1000
MICNKEVGNG DVSVKFKRLD AGNRVFENFP KFEPELMEVE QPVQYQKRAP
1010
GEAFPMTQMG EEVM
Length:1,014
Mass (Da):112,112
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62AA53AD69C586FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR796452 Genomic DNA Translation: CAM67500.2
UINB01000020 Genomic DNA Translation: SUZ41396.1

NCBI Reference Sequences

More...
RefSeqi
XP_001465252.2, XM_001465215.2

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CAM67500; CAM67500; LINJ_20_1210

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LinJ.20.1210:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5068668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lif:LINJ_20_1210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796452 Genomic DNA Translation: CAM67500.2
UINB01000020 Genomic DNA Translation: SUZ41396.1
RefSeqiXP_001465252.2, XM_001465215.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAM67500; CAM67500; LINJ_20_1210
GeneDBiLinJ.20.1210:pep
GeneIDi5068668
KEGGilif:LINJ_20_1210

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
InParanoidiA4HYW1

Family and domain databases

CDDicd00044 CysPc, 1 hit
Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR015232 DUF1935
IPR013780 Glyco_hydro_b
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
IPR036310 Smp-1-like_sf
PfamiView protein in Pfam
PF09149 DUF1935, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF101601 SSF101601, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4HYW1_LEIIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4HYW1
Secondary accession number(s): A0A2K4YT24, A0A381MHZ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: April 5, 2011
Last modified: June 5, 2019
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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