Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyruvate kinase

Gene

LBRM_34_0040

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (LBRM_30_2950)
  2. Phosphoglycerate kinase (LBRM_20_4190), Phosphoglycerate kinase (LBRM_30_3420)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase (LBRM_34_0010), Pyruvate kinase, Pyruvate kinase (LBRM_34_0040), Pyruvate kinase (LBRM_34_0060)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
ORF Names:LBRM_34_0040Imported
OrganismiLeishmania braziliensisImported
Taxonomic identifieri5660 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
Proteomesi
  • UP000007258 Componenti: Chromosome 35

Organism-specific databases

EuPathDBiTriTrypDB:LbrM.34.0040

Interactioni

Protein-protein interaction databases

STRINGi420245.XP_001568120.1

Structurei

3D structure databases

ProteinModelPortaliA4HM39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 316PKInterPro annotationAdd BLAST316
Domaini334 – 424PK_CInterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
InParanoidiA4HM39
KOiK00873
OMAiKHEAIEQ

Family and domain databases

CDDicd00288 Pyruvate_Kinase, 1 hit
Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A4HM39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVRMDFSH GSHEYHQTTI NNVRQAAAEL GVNIAIALDT KGPEIRTGLF
60 70 80 90 100
VGGVAVMEKD ATCYVTTDPA FSDKGTKDKF YIDYANLPKV VSPGGYIYID
110 120 130 140 150
DGILILQVQS HEDEQTLKCT VTNAHTISDR RGVNLPGCDV DLPAVSPKDC
160 170 180 190 200
ADLQFGVEQG VDIIFASFIR SAEQVVEVRK ALGAKGGDIM VICKIENHQG
210 220 230 240 250
VQNIDSIIEE SDGIMVARGD LGVEIPAEKV VVAQKILISK CNVAGKPVIC
260 270 280 290 300
ATQMLESMTY NPRPTRAEVS DVANAVFNGA DCVMLSGETA KGKYPNGVVQ
310 320 330 340 350
YMARICLEAQ SAINEYVFFN SIKKLQPIPM SVEEAVCSSA VNSVYETKAK
360 370 380 390 400
ALVVLSNTGR SARLVAKYRP NCPIVCVTTR LQTCRQLNIT QGVESVFFDA
410 420
DRLGHDEGKE DRVATGVEFA KSRG
Length:424
Mass (Da):45,894
Last modified:May 1, 2007 - v1
Checksum:iA425F2814E225EDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799009 Genomic DNA Translation: CAM43221.1
RefSeqiXP_001568120.1, XM_001568070.1

Genome annotation databases

EnsemblProtistsiCAM43221; CAM43221; LBRM_34_0040
GeneDBiLbrM.34.0040:pep
GeneIDi5419064
KEGGilbz:LBRM_34_0040

Similar proteinsi

Entry informationi

Entry nameiA4HM39_LEIBR
AccessioniPrimary (citable) accession number: A4HM39
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health