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Entry version 74 (17 Jun 2020)
Sequence version 2 (05 Apr 2011)
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Protein
Submitted name:

Putative calpain-like cysteine peptidase

Gene

LBRM_27_0600

Organism
Leishmania braziliensis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C02.A05

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Putative calpain-like cysteine peptidaseImported (EC:3.4.22.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LBRM_27_0600Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLeishmania braziliensisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5660 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeLeishmaniinaeLeishmaniaLeishmania braziliensis species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007258 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 27

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
TriTrypDB:LbrM.27.0600

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 304Calpain catalyticInterPro annotationAdd BLAST274
Domaini615 – 920Calpain catalyticInterPro annotationAdd BLAST306
Domaini4361 – 4636Calpain catalyticInterPro annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4282 – 4337DisorderedSequence analysisAdd BLAST56
Regioni4917 – 4972DisorderedSequence analysisAdd BLAST56

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1384 – 1404Sequence analysisAdd BLAST21
Coiled coili1905 – 1936Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4282 – 4297PolyampholyteSequence analysisAdd BLAST16
Compositional biasi4316 – 4337PolyampholyteSequence analysisAdd BLAST22
Compositional biasi4925 – 4963PolarSequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0045 Eukaryota
ENOG410XP0B LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4HFH5

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00704 CALPAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00230 CysPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49758 SSF49758, 3 hits
SSF54001 SSF54001, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50203 CALPAIN_CAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4HFH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGASSIDEVP DSGNMFVDHE FNKNNAGIAT KWISITQLYP NGVNQPLLPE
60 70 80 90 100
VFSREQFGQG NHYECFMISA LATLVRFPDV IRNCFVTQKV RQDGRYTFQF
110 120 130 140 150
FRGREWVRVE IDDTIPMEDG EVLYLRSPTE HWWPLLLEKA YAKFYTAYDH
160 170 180 190 200
LEGCTLQETF HDLTGNPVLN IPMDAKLAKA ANCNVLEGCY WLDLAQRIHS
210 220 230 240 250
GEFVASVLTK DIELETMGLQ REQQYGLLDI FSLQGTSALD DIVIRLHNPF
260 270 280 290 300
EDDEFVYTGP LNQNDLAWSD KHRVKYDVNN PRSIFLPLNV FLRIVNSMQL
310 320 330 340 350
CYISTVASDA TYFEDEWKGE SAGGNPTSVS WRKNPLYCFR NHGTEAVTLT
360 370 380 390 400
VVVKQDDQRH RKGPKEETTY KQCGMILSQC TYHYPIPTFW VTANNHKPIF
410 420 430 440 450
KSLFLNSREV ANTIKIPPQS LCYLVPSCMH KGDEAKFLLA VYRMAHEDYS
460 470 480 490 500
NITINKLTGT EMDWESPATA EVQLQMQTKD RVDFYVDEAT DVHILLHQTK
510 520 530 540 550
PYVSKSGGDA MTEDYMGMYL YDDTDRKVAG VHAATNFRET SVIHRLPRSG
560 570 580 590 600
RYAISITCPR GKGDVPAKVT IVSSFGSQVR RVTAPEDASM LPDEAESVEE
610 620 630 640 650
NEGIRPRVTR IDYEAFQEPS ADVPERPDSN VPFEDRGFMQ WNGDVTMGPW
660 670 680 690 700
VHIGDLYPEG KTVPLLPNEL RRDQFGQGDH YDCSTLTAFA ALLERHPDVI
710 720 730 740 750
RNCFVSKNPR KDGRYTFQFH RYGQWVKVEI DDRIPMVKDD TVFCRSPTHH
760 770 780 790 800
WWPLLLEKAY AKFYTLYENL AGCSLAEVFH DFSGRPVINT PLDLPTTMPA
810 820 830 840 850
ELDITSPMYW LRLRDELRTT AVGAQTGDAT ENLGLAPHQF YGVLDILVTS
860 870 880 890 900
ASPPRSLSEV VVQLHNPYAA YTYTGPMSDP ADPRWASRGM HHISTMQNTI
910 920 930 940 950
CVPADIFLHT FFIMSQVHLL GLIEPCWNFH SEWGDGTNGG NPSLLTWREN
960 970 980 990 1000
PLYTVVNTSN EAVEIMAMIR QPDKRRQLHL LPELSYVRCD LLLAQSMEND
1010 1020 1030 1040 1050
SIPTYLVTHN NHQVVQKGIF LNYREVASKI RVPPQSQCYL VPTAMYHEKS
1060 1070 1080 1090 1100
IFLLSYWYRR PADERAVSIS RLRLNVARDL PAVKHVTMVP EGKDRVDFLV
1110 1120 1130 1140 1150
DVPTVAHILL SQWNRDARSS SDVRTDNYVG MYLYDDAKQQ VARVSAASNL
1160 1170 1180 1190 1200
KEIGLVAYLP AQGRYVLSIT CPAARDVEVK CRVEIVCVEA ARVRITDAYE
1210 1220 1230 1240 1250
SAQCCEDLKG QPLVELVDSD TLVDGDRHTT EPVEVAVEKR QAVSAAQLQE
1260 1270 1280 1290 1300
KTSRASPADA EAKERALSSS FMRPQYLGIP TGDLPLMENP AFAKMAQERE
1310 1320 1330 1340 1350
QLRRHLLQNA ARVNTLENTM DNMAARMADD MHKRERAFLG SQAEGIPLEL
1360 1370 1380 1390 1400
LPLNEDEQFT GLEHTLRLAM KDPEKNRDDV AIWQEMLKKR VREVANEKKA
1410 1420 1430 1440 1450
SERDLFLNPM HLGLPVDDLP LDIDPEFHLL EVARLRERQQ EPCDEAKIRK
1460 1470 1480 1490 1500
LNDALNERAE GLAVAELAAD RQHMKPEHLH VAIDELPLSE NRNFVLKEAL
1510 1520 1530 1540 1550
RREKMKSSCE GATAVAALED ELNDMAKDMA AELLAKQRPS YLAPEHNGRR
1560 1570 1580 1590 1600
IADLPLNTSN DFLAKERRRR DLLKQPNPDM NKVIEIEEEL GHMASSMAIA
1610 1620 1630 1640 1650
MNAAERPQYM KDSYHTKNLG ELPLNADTTI TTLEAQRARL KYDPLRNAAA
1660 1670 1680 1690 1700
IRATEELINS RAAALAKSMM HEERVRLYGK PNGVPVNLLD LHEDSLIRHL
1710 1720 1730 1740 1750
EEERMNLLSN PATNPHVINT IEEKLKARAA EIADNFRANM RAEITGEQCR
1760 1770 1780 1790 1800
SPSLMSVGSD APCQDMEEKL YTLLSEDPIS NEEQIMDLKE AIRKRHGELK
1810 1820 1830 1840 1850
RQAVHALRSF LEEAPFGILL AEVGLDEDPE YMEKEADLQK SLANNSSATQ
1860 1870 1880 1890 1900
IKAIRDSMQQ RVYELAAEKL VRRYPFLSKR PAGIPLAELP ILSRDQPFLQ
1910 1920 1930 1940 1950
AITDLEKTEA DEQKTEAQLR AQQEALNQRL HAVAEEQKWK EREMFLVATT
1960 1970 1980 1990 2000
AAVPLRLLPL DNDIDFVHLE QKRRSSLRSG NALDIRTIEN TLNERAHVLA
2010 2020 2030 2040 2050
SEKKWADRGK VLDPKPEGVP LSHVPLDEDA EFVALEDEWR GLAQDPRRNE
2060 2070 2080 2090 2100
RALADLEKAM NDRAHVLASE TKWADRGKVL DPKPEGVPLS HVPLDEDAEF
2110 2120 2130 2140 2150
VALEDEWRGL AQDPRRNERA LADLEKAMND RAHVLASEKK WADRGKVLDP
2160 2170 2180 2190 2200
KPEGVPLSHV PLDEDAEFVA LEDEWRGLAQ DPRRNERALA DLEKAMNDRA
2210 2220 2230 2240 2250
HVLASETKWA DRGKVLDPKP EGVPLSHVPL DEDAEFVALE DEWRGLAQDP
2260 2270 2280 2290 2300
RRNERALADL EKAMNDRAHV LASETKWADR GKVLDPKPEG VPLSHVPLDE
2310 2320 2330 2340 2350
DAEFVALEDE WRGLAQDPRR NERALADLEK AMNDRAHVLA SETKWADRGK
2360 2370 2380 2390 2400
VLDPKPEGVP LSHVPLDEDA EFVALEDEWR GLAQDPRRNE RALADLEKAM
2410 2420 2430 2440 2450
NDRAHVLASE KKWADRGKVL DPKPEGVPLS HVPLDEDAEF VALEDEWRGL
2460 2470 2480 2490 2500
AQDPRRNERA LADLEKAMND RAHVLASEKK WADRGKVLDP KPEGVPLSHV
2510 2520 2530 2540 2550
PLDEDAEFVA LEDEWRGLAQ DPRRNERALA DLEKAMNDRA HVLASETKWA
2560 2570 2580 2590 2600
DRGKVLDPKP EGVPLSHVPL DEDAEFVALE DEWRGLAQDP RRNERALADL
2610 2620 2630 2640 2650
EKAMNDRAHV LASETKWADR GKVLDPKPEG VPLSHVPLDE DAEFVALEDE
2660 2670 2680 2690 2700
WRGLAQDPRR NERALADLEK AMNDRAHVLA SETKWADRGK VLDPKPEGVP
2710 2720 2730 2740 2750
LSHVPLDEDA EFVALEDEWR GLAQDPRRNE RALADLEKAM NDRAHVLASE
2760 2770 2780 2790 2800
TKWADRGKVL DPKPEGVPLS HVPLDEDAEF VALEDEWRGL AQDPRRNERA
2810 2820 2830 2840 2850
LADLEKAMND RAHVLASETK WADRGKVLDP KPEGVPLSHV PLDEDAEFVA
2860 2870 2880 2890 2900
LEDEWRGLAQ DPRRNERALA DLEKAMNDRA HVLASETKWA DRGKVLDPKP
2910 2920 2930 2940 2950
EGVPLSHVPL DEDAEFVALE DEWRGLAQDP RRNERALADL EKAMNDRAHV
2960 2970 2980 2990 3000
LASETKWADR GKVLDPKPEG VPLSHVPLDE DAEFVALEDE WRGLAQDPRR
3010 3020 3030 3040 3050
NERALADLEK AMNDRAHVLA SETKWADRGK VLDPKPEGVP LSHVPLDEDA
3060 3070 3080 3090 3100
EFVALEDEWR GLAQDPRRNE RALADLEKAM NDRAHVLASE TKWADRGKVL
3110 3120 3130 3140 3150
DPKPEGVPLS HVPLDEDAEF VALEDEWRGL AQDPRRNERA LADLEKAMND
3160 3170 3180 3190 3200
RAHVLASETK WADRGKVLDP KPEGVPLSHV PLDEDAEFVA LEDEWRGLAQ
3210 3220 3230 3240 3250
DPRRNERALA DLEKAMNDRA HVLASETKWA DRGKVLDPKP EGVPLSHVPL
3260 3270 3280 3290 3300
DEDAEFVALE DEWRGLAQDP RRNERALADL EKAMNDRAHV LASETKWADR
3310 3320 3330 3340 3350
GKVLDPKPEG VPLSHVPLDE DAEFVALEDE WRGLAQDPRR NERALADLEK
3360 3370 3380 3390 3400
AMNDRAHVLA SETKWADRGK VLDPKPEGVP LSHVPLDEDA EFVALEDEWR
3410 3420 3430 3440 3450
GLAQDPRRNE RALADLEKAM NDRAHVLASE KKWADRGKVL DPKPEGVPLS
3460 3470 3480 3490 3500
HVPLDEDAEF VALEDEWRGL AQDPRRNERA LADLEKAMND RAHVLASETK
3510 3520 3530 3540 3550
WADRGKVLDP KPEGVPLSHV PLDEDAEFVA LEDEWRGLAQ DPRRNERALA
3560 3570 3580 3590 3600
DLEKAMNDRA HVLASETKWA DRGKVLDPKP EGVPLSHVPL DEDAEFVALE
3610 3620 3630 3640 3650
DEWRGLAQDP RRNERALADL EKAMNDRAHV LASETKWADR GKVLDPKPEG
3660 3670 3680 3690 3700
VPLSHVPLDE DAEFVALEDE WRGLAQDPRR NERALADLEK AMNDRAHVLA
3710 3720 3730 3740 3750
SETKWADRGK VLDPKPEGVP LSHVPLDEDA EFVALEDEWR GLAQDPRRNE
3760 3770 3780 3790 3800
RALADLEKAM NDRAHVLASE TKWADRGKVL DPKPEGVPLS HVPLDEDAEF
3810 3820 3830 3840 3850
VALEDEWRGL AQDPRRNERA LADLEKAMND RAHVLASETK WADRGKVLDP
3860 3870 3880 3890 3900
KPEGVPLSHV PLDEDAEFVA LEDEWRGLAQ DPRRNERALA DLEKAMNDRA
3910 3920 3930 3940 3950
HVLASETKWA DRGKVLDPKP EGVPLSHVPL DEDAEFVALE DEWRGLAQDP
3960 3970 3980 3990 4000
RRNAKEMAAI EEEMMNRVYF LARGLAYCQD CLEKKDECSC GSGGMGIRKD
4010 4020 4030 4040 4050
VGSCEEVDGV GALNVMMGRR TTERGFDGLL GSVVDGVPTV LLKLSDDDVF
4060 4070 4080 4090 4100
CKQNDEYLDV LKADSELKRI RQLEGEMLDR AHVLARRFKD EIRSAVVGEK
4110 4120 4130 4140 4150
MALLAEGGAE LDRDETFVAL ERELFNLEAS DDRGGGCRRA ALVDSLRQRA
4160 4170 4180 4190 4200
SELAEIPLHG VCRGISAETV SEVSQKELFD NQPGGRRQNT TPKKNGRYVS
4210 4220 4230 4240 4250
TVMGRSTWNV ADEIEAGESY LFLGKEVYGI PLDKIPYRDD EVFRGLSEER
4260 4270 4280 4290 4300
RRVMNHPEDY SAGYQEEVED ALRRRVEELA DEYKRDHIKH TTASDGQPKK
4310 4320 4330 4340 4350
PRKPNGAPGE SCSPPRRPQG KKKLREVEER TEEHRRETVE LASAFTDPPF
4360 4370 4380 4390 4400
HDANSQAEDA WPRIADVYPE GLMQPLLPNY PKTSDMASPA GDLTYLAPFL
4410 4420 4430 4440 4450
AALSRQPPLL HRLFQVKAHP VRAPYTFVFF DPNGTPVTVG IDDRIPCDAN
4460 4470 4480 4490 4500
GVPRFTVSPN GAWWPLLVEK AYAKYVGGYD RFDECTSHET LRDLTGRPVT
4510 4520 4530 4540 4550
HLPLDAKLSA EVSGCNYRDV TFWRRIHEQL ERGDVFMAVS SDMTPDGIHR
4560 4570 4580 4590 4600
HCHYAVFDVI ETVPGSNDPS DVVVKIHNCY RDAPEYHGPL AKGDSDWTPK
4610 4620 4630 4640 4650
LRSVCKADPE SEPEFLYVPQ PVFLRNFSSM QRCHVNCGDR LTVSGEWTGA
4660 4670 4680 4690 4700
CSGGNPTYTT FRRNPMYLVQ NNSNRNVTVL AELRHSAPVY YDAHNLGVYH
4710 4720 4730 4740 4750
LTALALLRPD SNAQLVAPLL AYNTHKFLQK GLLTDAREVC VEMELPANST
4760 4770 4780 4790 4800
CYLIPYTKKK ACFGKYQLSV YPQDNPVNLT TLRPIDETHS CLTKDVLVQP
4810 4820 4830 4840 4850
GTGTSVRVDL VVSSPCDVHA LLHQNKVTDP KSIKRGDHLA EDEIFMAVYE
4860 4870 4880 4890 4900
NNTALVCSTG DASNAREHAI AFQATKPGRY TFLVGCPSRP VSGDAPCTLI
4910 4920 4930 4940 4950
IYTPTYAQAR FASLNEPIRP NVPPRVQSSK ATTSSASARL GAWQPQVPQR
4960 4970
SASTSSIAAQ TPRGNPRNRR YL
Length:4,972
Mass (Da):560,961
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D6BD9966C3765E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FR799002 Genomic DNA Translation: CAM45337.2

NCBI Reference Sequences

More...
RefSeqi
XP_001565819.2, XM_001565769.2

Genome annotation databases

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
LbrM.27.0600:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5416680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lbz:LBRM_27_0600

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799002 Genomic DNA Translation: CAM45337.2
RefSeqiXP_001565819.2, XM_001565769.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC02.A05

Genome annotation databases

GeneDBiLbrM.27.0600:pep
GeneIDi5416680
KEGGilbz:LBRM_27_0600

Organism-specific databases

EuPathDBiTriTrypDB:LbrM.27.0600

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
InParanoidiA4HFH5

Family and domain databases

InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR036213 Calpain_III_sf
IPR038765 Papain-like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 2 hits
PF00648 Peptidase_C2, 3 hits
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 3 hits
SSF54001 SSF54001, 3 hits
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4HFH5_LEIBR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4HFH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: April 5, 2011
Last modified: June 17, 2020
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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