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Protein

Gap junction gamma-1 protein

Gene

GJC1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-112303 Electric Transmission Across Gap Junctions
R-SSC-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:GJC1
Synonyms:GJA7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 45HelicalSequence analysisAdd BLAST23
Topological domaini46 – 75ExtracellularSequence analysisAdd BLAST30
Transmembranei76 – 95HelicalSequence analysisAdd BLAST20
Topological domaini96 – 175CytoplasmicSequence analysisAdd BLAST80
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 228ExtracellularSequence analysisAdd BLAST30
Transmembranei229 – 248HelicalSequence analysisAdd BLAST20
Topological domaini249 – 396CytoplasmicSequence analysisAdd BLAST148

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130061 – 396Gap junction gamma-1 proteinAdd BLAST396

Proteomic databases

PaxDbiA4GVD1
PRIDEiA4GVD1

Expressioni

Gene expression databases

BgeeiENSSSCG00000021306
GenevisibleiA4GVD1 SS

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000021968

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231126
HOVERGENiHBG009576
InParanoidiA4GVD1
KOiK07616
OMAiIMYGVSC
OrthoDBiEOG091G08B8
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002265 Connexin45
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01136 CONNEXINA6
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4GVD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKEQNQSKP KHDGRRRIRE DGLMKIYVLQ LLARTMFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RVPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELE DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEET LPADLETLQR EIRMAQERLD
360 370 380 390
LAIQAYNHQN NPHGPREKKA KVGSKAGSNK SSASSKSGDG KTSVWI
Length:396
Mass (Da):45,598
Last modified:April 17, 2007 - v1
Checksum:iDF10A8FD9C9A2F49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF437944 mRNA Translation: ABO28479.1
RefSeqiNP_001090988.1, NM_001097519.1
XP_005668761.1, XM_005668704.2
XP_005668762.1, XM_005668705.2
XP_005668763.1, XM_005668706.2
XP_005668765.1, XM_005668708.2
XP_013836322.1, XM_013980868.1
UniGeneiSsc.43862
Ssc.95427

Genome annotation databases

EnsembliENSSSCT00000030363; ENSSSCP00000021968; ENSSSCG00000021306
ENSSSCT00000049822; ENSSSCP00000043247; ENSSSCG00000021306
ENSSSCT00000051568; ENSSSCP00000040946; ENSSSCG00000021306
GeneIDi100048959
KEGGissc:100048959

Similar proteinsi

Entry informationi

Entry nameiCXG1_PIG
AccessioniPrimary (citable) accession number: A4GVD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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