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Protein

Gap junction gamma-1 protein

Gene

Gjc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-112303 Electric Transmission Across Gap Junctions
R-RNO-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-1 protein
Alternative name(s):
Connexin-45
Short name:
Cx45
Gap junction alpha-7 protein
Gene namesi
Name:Gjc1
Synonyms:Gja7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi628889 Gjc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 18CytoplasmicSequence analysisAdd BLAST18
Transmembranei19 – 39HelicalSequence analysisAdd BLAST21
Topological domaini40 – 75ExtracellularSequence analysisAdd BLAST36
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 175CytoplasmicSequence analysisAdd BLAST79
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Topological domaini199 – 229ExtracellularSequence analysisAdd BLAST31
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 396CytoplasmicSequence analysisAdd BLAST146

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003695431 – 396Gap junction gamma-1 proteinAdd BLAST396

Proteomic databases

PaxDbiA4GG66
PRIDEiA4GG66

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSRNOG00000048838
GenevisibleiA4GG66 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066371

Structurei

3D structure databases

ProteinModelPortaliA4GG66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili303 – 358Sequence analysisAdd BLAST56

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFK3 Eukaryota
ENOG410Z7PN LUCA
GeneTreeiENSGT00910000143998
InParanoidiA4GG66
KOiK07616
OMAiIMYGVSC
OrthoDBiEOG091G08B8
PhylomeDBiA4GG66

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002265 Connexin45
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01136 CONNEXINA6
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4GG66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSFLTRLL EEIHNHSTFV GKIWLTVLIV FRIVLTAVGG ESIYYDEQSK
60 70 80 90 100
FVCNTEQPGC ENVCYDAFAP LSHVRFWVFQ IILVATPSVM YLGYAIHKIA
110 120 130 140 150
KMEHGEADKK AARSKPYAMR WKQHRALEET EEDHEEDPMM YPEMELESEK
160 170 180 190 200
ENKEQSQPKP KHDGRRRIRE DGLMKIYVLQ LLARTVFEVG FLIGQYFLYG
210 220 230 240 250
FQVHPFYVCS RLPCPHKIDC FISRPTEKTI FLLIMYGVTG LCLLLNIWEM
260 270 280 290 300
LHLGFGTIRD SLNSKRRELD DPGAYNYPFT WNTPSAPPGY NIAVKPDQIQ
310 320 330 340 350
YTELSNAKIA YKQNKANIAQ EQQYGSHEEH LPADLETLQR EIRMAQERLD
360 370 380 390
LAIQAYHHQN NPHGPREKKA KVGSKSGSNK SSISSKSGDG KTSVWI
Length:396
Mass (Da):45,666
Last modified:April 17, 2007 - v1
Checksum:i9CD5721BB071B65C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ871218 Genomic DNA Translation: ABI54096.1
DQ871218 Genomic DNA Translation: ABI54097.1
DQ871218 Genomic DNA Translation: ABI54098.1
DQ871218 Genomic DNA Translation: ABI54099.1
CH473948 Genomic DNA Translation: EDM06232.1
BC166405 mRNA Translation: AAI66405.1
RefSeqiNP_001078850.1, NM_001085381.1
XP_017452538.1, XM_017597049.1
XP_017452539.1, XM_017597050.1
UniGeneiRn.195419

Genome annotation databases

EnsembliENSRNOT00000073372; ENSRNOP00000066371; ENSRNOG00000048838
ENSRNOT00000093570; ENSRNOP00000076255; ENSRNOG00000048838
GeneIDi266706
KEGGirno:266706

Similar proteinsi

Entry informationi

Entry nameiCXG1_RAT
AccessioniPrimary (citable) accession number: A4GG66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 17, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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