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Protein

Thymidylate kinase

Gene

tmk

Organism
Herminiimonas arsenicoxydans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHARS204773:HEAR_RS06505-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:HEAR1396
OrganismiHerminiimonas arsenicoxydans
Taxonomic identifieri204773 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesOxalobacteraceaeHerminiimonas
Proteomesi
  • UP000006697 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000232021 – 204Thymidylate kinaseAdd BLAST204

Proteomic databases

PRIDEiA4G4Y1

Interactioni

Protein-protein interaction databases

STRINGi204773.HEAR1396

Structurei

3D structure databases

ProteinModelPortaliA4G4Y1
SMRiA4G4Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229078
KOiK00943
OMAiFLYTADH
OrthoDBiPOG091H02B9

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit

Sequencei

Sequence statusi: Complete.

A4G4Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKAKFITFE GIDGAGKSTH LSFVADLLRA SKKNVVVTRE PGGTSLGEAL
60 70 80 90 100
RTILLHEKMH LETEALLMFA ARREHIAQLI EPALARGDWV ISDRFTDATF
110 120 130 140 150
AYQGGGRKLD RQKLSVLEQW VHPHLQPDLT LLFDVPLDVA RARLDATRTL
160 170 180 190 200
DKFEQEQADF FAATRAEYLR RAAEFPQRFR IIDSTQAIAT IQEQLRDIIA

GLAP
Length:204
Mass (Da):22,967
Last modified:April 17, 2007 - v1
Checksum:i1C19DECD0B77403F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU207211 Genomic DNA Translation: CAL61568.1
RefSeqiWP_011870902.1, NC_009138.1

Genome annotation databases

EnsemblBacteriaiCAL61568; CAL61568; HEAR1396
KEGGihar:HEAR1396

Similar proteinsi

Entry informationi

Entry nameiKTHY_HERAR
AccessioniPrimary (citable) accession number: A4G4Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: June 20, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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