Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

LIM and senescent cell antigen-like-containing domain protein

Gene

LIMS1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Names & Taxonomyi

Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain proteinUniRule annotation
Gene namesi
Name:LIMS1Imported
Synonyms:MGC142792Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:50211 LIMS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junctionUniRule annotation, Cell membraneUniRule annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSBTAG00000010971 Expressed in 9 organ(s), highest expression level in lung

Interactioni

Subunit structurei

Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014566

Structurei

3D structure databases

SMRiA4FV50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 81LIM zinc-bindingInterPro annotationAdd BLAST62
Domaini83 – 140LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini145 – 202LIM zinc-bindingInterPro annotationAdd BLAST58
Domaini203 – 262LIM zinc-bindingInterPro annotationAdd BLAST60
Domaini263 – 322LIM zinc-bindingInterPro annotationAdd BLAST60

Keywords - Domaini

LIM domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053
OMAiPFPDGIY
OrthoDBiEOG091G08K3
TreeFamiTF314113

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 5 hits

Sequencei

Sequence statusi: Complete.

A4FV50-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGVASGMTN SNMANALANA SCERCRGGFA PAEKIVNSNG ELYHEQCFVC
60 70 80 90 100
AQCFQQFPEG LFYEFEGRKY CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN
110 120 130 140 150
SWHPECFRCD LCQEVLADIG FVKNAGRHLC RPCHNREKAR GLGKYICQKC
160 170 180 190 200
HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE LYCLPCHDKM
210 220 230 240 250
GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA
260 270 280 290 300
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVHCFAC STCSAKLTLK
310 320 330
NKFVEFDMKP VCKKCYEKFP LELKKRLKKL AETLGRK
Length:337
Mass (Da):38,422
Last modified:April 17, 2007 - v1
Checksum:iCDC5081AF68685D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02031034 Genomic DNA No translation available.
DAAA02031035 Genomic DNA No translation available.
BC123746 mRNA Translation: AAI23747.1
RefSeqiNP_001076964.1, NM_001083495.1
UniGeneiBt.104115

Genome annotation databases

EnsembliENSBTAT00000014566; ENSBTAP00000014566; ENSBTAG00000010971
GeneIDi540281
KEGGibta:540281

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02031034 Genomic DNA No translation available.
DAAA02031035 Genomic DNA No translation available.
BC123746 mRNA Translation: AAI23747.1
RefSeqiNP_001076964.1, NM_001083495.1
UniGeneiBt.104115

3D structure databases

SMRiA4FV50
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014566

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014566; ENSBTAP00000014566; ENSBTAG00000010971
GeneIDi540281
KEGGibta:540281

Organism-specific databases

CTDi3987
VGNCiVGNC:50211 LIMS1

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00760000118910
HOGENOMiHOG000253950
HOVERGENiHBG000053
OMAiPFPDGIY
OrthoDBiEOG091G08K3
TreeFamiTF314113

Enzyme and pathway databases

ReactomeiR-BTA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Gene expression databases

BgeeiENSBTAG00000010971 Expressed in 9 organ(s), highest expression level in lung

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 3 hits
PS50023 LIM_DOMAIN_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA4FV50_BOVIN
AccessioniPrimary (citable) accession number: A4FV50
Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again