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Protein

Receptor protein serine/threonine kinase

Gene

ACVRL1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • cellular response to transforming growth factor beta stimulus Source: BHF-UCL

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:ACVRL1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 141HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500266792823 – 503Receptor protein serine/threonine kinaseSequence analysisAdd BLAST481

Structurei

3D structure databases

ProteinModelPortaliA4FUX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 201GSInterPro annotationAdd BLAST30
Domaini202 – 492Protein kinaseInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
HOGENOMiHOG000230587
HOVERGENiHBG054502
KOiK13594

Family and domain databases

InterProiView protein in InterPro
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

A4FUX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLNLPRRRL LMLLIALGLT QGDPLKPSRG PLVTCTCENP HCKGPTCQGS
60 70 80 90 100
WCTVVLVWED GHLREYRGCG NMHPEVCRAR PTEFVNHYCC YSPLCNHNVS
110 120 130 140 150
LTLEATQTAP EQPQGDGQLP LILGPVLAFL VLVALGALGL WHVRRRKEKQ
160 170 180 190 200
RGANSELGES SLILKPSEQG DSMLGDLLDS DCTTGSGSGL PFLVQRTVAR
210 220 230 240 250
QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF RETEIYNTVL
260 270 280 290 300
LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPQLAL
310 320 330 340 350
KLAVSAACGL AHLHVEIFGT QGKPAIAHRD LKSRNVLVKS NLQCCIADLG
360 370 380 390 400
LAVMHSQGSD YLDIGNNPRV GTKRYMAPEV LEEQIRTDCF ESYKWTDIWA
410 420 430 440 450
FGLVLWEITR RTIVNGIVED YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT
460 470 480 490 500
IPNRLAADPV LSGLAQMMRE CWYPNPSARL TALRIKKTLQ KLSNGLQKPK

VIP
Length:503
Mass (Da):56,279
Last modified:April 17, 2007 - v1
Checksum:i7B33BDA47068B2C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123398 mRNA Translation: AAI23399.1
RefSeqiNP_001076948.1, NM_001083479.1
UniGeneiBt.28710

Genome annotation databases

GeneIDi534536
KEGGibta:534536

Similar proteinsi

Entry informationi

Entry nameiA4FUX2_BOVIN
AccessioniPrimary (citable) accession number: A4FUX2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: June 20, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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