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Entry version 76 (16 Jan 2019)
Sequence version 1 (17 Apr 2007)
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Protein
Submitted name:

RAB3 GTPase activating protein catalytic subunit 1

Gene

RAB3GAP1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab guanyl-nucleotide exchange factor activity Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-BTA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-BTA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RAB3 GTPase activating protein catalytic subunit 1Imported
Submitted name:
RAB3GAP1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB3GAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:33653 RAB3GAP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000013449 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000017891

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2390 Eukaryota
ENOG410Y2R4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006705

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253924

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079116

KEGG Orthology (KO)

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KOi
K18270

Identification of Orthologs from Complete Genome Data

More...
OMAi
EEYNLYN

Database of Orthologous Groups

More...
OrthoDBi
536022at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314500

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026147 Rab3-GAP_cat_su

The PANTHER Classification System

More...
PANTHERi
PTHR21422 PTHR21422, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4FUE5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADSEPESE VFEITDFTTA SEWERFISKV EEVLNDWKLI GNSVGKPLEK
60 70 80 90 100
GIFTSGTWEE KSDEISFADF KFSVTHHYLV QESTDKEAKD EVLEDVIPQP
110 120 130 140 150
MQDLLCMNND FPPRAHCLVR WYGLREFVVI APAANNDAVL SESKCNLLLS
160 170 180 190 200
SVSIALGNTG CQVPLFVQIH HKWRRMYVGE CQGPGVRTDF EMVHLRKVPN
210 220 230 240 250
QYTHLSGLLD IFKSKIGCPL TPLPPVNIAI RFTYVLQDWQ QYFWPQQPPD
260 270 280 290 300
IDALVGGEVG GLEFGKLPFG ACEDPISELH LATTWPHLTE GIIVDNDVYS
310 320 330 340 350
DLDPMQAPHW SVRVRKADNP QCLLGDFVTE FFKICRRKES TDEILGRSTF
360 370 380 390 400
EEEGREIADI THALSKLTEP APVPIHKLSV SNMVHTAKKK IRKHRGVEES
410 420 430 440 450
PLNNDVLNTI LLFLFPDAAS EKPLDGTSST DNSNPPLESE EYNLYNQFKS
460 470 480 490 500
APSDSLTYKL ALCLCMINFY HGGLKGVAHL WQEFVLEMRF RWENNFLIPG
510 520 530 540 550
LASGPPDLRC CLLHQKLQML NCCIERKKAR DEGRKTSPSD NVTNTYSGDA
560 570 580 590 600
GKSGDQLGPD NLRETDKDKG EVGKSWDSWS DSEEEFFECL SDTEELKGNG
610 620 630 640 650
QESGKKGGPK EMASLKPEGR LHQHGKLTLL HNGEPLYIPV TQEPAPMTED
660 670 680 690 700
LLEEQSEVLA KLGTSAEGAH LRARMQSACL LSDMESFKAA NPGCFLEDFV
710 720 730 740 750
RWYSPRDYIE EEVVDEKGNM VLKGELSARM KIPSNMWVEA WETAKPIPAR
760 770 780 790 800
RQRRLFDDTR EAEKVLHYLA VQKPADLARH LLPCVIHAAV LKVKEEESLE
810 820 830 840 850
NISSVKKIIK QIISHSSKVL HFPNPEDKKL EEIIHQITNV EAIIARARSL
860 870 880 890 900
KAKFGTEKCE QEEEKEDLER FVSCLLEQPE VLVVGAGRGH AGRIIHKLFV
910 920 930 940 950
NAQRAATMTP AEEELKRMGP PEEKRQNLAA DFPPPAGREL ILRTAVPRPA
960 970 980
PYSRALPQRM YSVLTKEDFR LAGAFSSDTS FF
Length:982
Mass (Da):110,713
Last modified:April 17, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E88990DE1B26E72
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DAAA02005002 Genomic DNA No translation available.
DAAA02005003 Genomic DNA No translation available.
BC114755 mRNA Translation: AAI14756.1

NCBI Reference Sequences

More...
RefSeqi
NP_001076952.1, NM_001083483.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Bt.6988

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000017891; ENSBTAP00000017891; ENSBTAG00000013449

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
535393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:535393

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02005002 Genomic DNA No translation available.
DAAA02005003 Genomic DNA No translation available.
BC114755 mRNA Translation: AAI14756.1
RefSeqiNP_001076952.1, NM_001083483.1
UniGeneiBt.6988

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017891

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017891; ENSBTAP00000017891; ENSBTAG00000013449
GeneIDi535393
KEGGibta:535393

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22930
VGNCiVGNC:33653 RAB3GAP1

Phylogenomic databases

eggNOGiKOG2390 Eukaryota
ENOG410Y2R4 LUCA
GeneTreeiENSGT00390000006705
HOGENOMiHOG000253924
HOVERGENiHBG079116
KOiK18270
OMAiEEYNLYN
OrthoDBi536022at2759
TreeFamiTF314500

Enzyme and pathway databases

ReactomeiR-BTA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-BTA-8876198 RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

BgeeiENSBTAG00000013449 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR026147 Rab3-GAP_cat_su
PANTHERiPTHR21422 PTHR21422, 1 hit
PfamiView protein in Pfam
PF13890 Rab3-GTPase_cat, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4FUE5_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4FUE5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: January 16, 2019
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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