UniProtKB - A4FUD9 (MCM3_BOVIN)
DNA replication licensing factor MCM3
MCM3
Functioni
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 345 – 352 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
- DNA replication origin binding Source: GO_Central
- single-stranded DNA binding Source: GO_Central
GO - Biological processi
- DNA strand elongation involved in DNA replication Source: GO_Central
- double-strand break repair via break-induced replication Source: GO_Central
- mitotic DNA replication initiation Source: GO_Central
- pre-replicative complex assembly involved in nuclear cell cycle DNA replication Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | Cell cycle, DNA replication |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MCM3 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:31309, MCM3 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Note: Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.By similarity
Cytoskeleton
- centrosome Source: Ensembl
Nucleus
- CMG complex Source: UniProtKB
- nucleus Source: GO_Central
Other locations
- MCM complex Source: UniProtKB
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000318902 | 2 – 808 | DNA replication licensing factor MCM3Add BLAST | 807 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 160 | PhosphoserineBy similarity | 1 | |
Modified residuei | 275 | PhosphoserineBy similarity | 1 | |
Modified residuei | 293 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 535 | Phosphoserine; by ATMBy similarity | 1 | |
Modified residuei | 547 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 611 | PhosphoserineBy similarity | 1 | |
Modified residuei | 668 | PhosphoserineBy similarity | 1 | |
Modified residuei | 672 | PhosphoserineBy similarity | 1 | |
Modified residuei | 681 | PhosphoserineBy similarity | 1 | |
Modified residuei | 708 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 713 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 722 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 728 | PhosphoserineBy similarity | 1 | |
Modified residuei | 734 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | A4FUD9 |
PRIDEi | A4FUD9 |
Interactioni
Subunit structurei
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By similarity). Associated with the replication-specific DNA polymerase alpha (By similarity).
Interacts with MCMBP.
Interacts with ANKRD17 (By similarity).
Interacts with MCM3AP; this interaction leads to MCM3 acetylation (By similarity).
Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014194 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 295 – 502 | MCMAdd BLAST | 208 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 477 – 480 | Arginine finger | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0479, Eukaryota |
GeneTreei | ENSGT01010000222249 |
InParanoidi | A4FUD9 |
OrthoDBi | 266497at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR031327, MCM IPR008046, Mcm3 IPR018525, MCM_CS IPR001208, MCM_dom IPR041562, MCM_lid IPR027925, MCM_N IPR033762, MCM_OB IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase |
PANTHERi | PTHR11630, PTHR11630, 1 hit |
Pfami | View protein in Pfam PF00493, MCM, 1 hit PF17855, MCM_lid, 1 hit PF14551, MCM_N, 1 hit PF17207, MCM_OB, 1 hit |
PRINTSi | PR01657, MCMFAMILY PR01659, MCMPROTEIN3 |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00350, MCM, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00847, MCM_1, 1 hit PS50051, MCM_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAGTVVLDDV ELREAQRDYL DFLDDEEDQG IYQSKVRELI SDNQYRLIVN
60 70 80 90 100
VNDLRRKNEK RANRLLSNAF EELVAFQRAL KDFVASIDAT YAKQYEEFYI
110 120 130 140 150
GLEGSFGSKH VSPRTLTSCF LSCVVCVEGI VTKCSLVRPK VVRSVHYCPA
160 170 180 190 200
TKKTIERRYS DLTSLVAFPS SSVYPTKDEE NNPLETEYGL SVYKDHQIIT
210 220 230 240 250
IQEMPEKAPA GQLPRSVDVI LDDDLVDRVK PGDRVQVVGT YRCLPGKKGG
260 270 280 290 300
YTSGTFRTVL IACNVKQMSK DVQPSFSAED IAKIKKFSKT RSKDIFDQLA
310 320 330 340 350
RSLAPSIHGH DYVKKAILCL LLGGVERDLE NGSHIRGDIN ILLIGDPSVA
360 370 380 390 400
KSQLLRYVLC TAPRAIPTTG RGSSGVGLTA AVTTDQETGE RRLEAGAMVL
410 420 430 440 450
ADRGVVCIDE FDKMSDMDRT AIHEVMEQGR VTIAKAGIHA RLNARCSVLA
460 470 480 490 500
AANPVYGRYD QYKTPMENIG LQDSLLSRFD LLFIMLDQMD PEQDREISDH
510 520 530 540 550
VLRMHRYRAP GEQDGDAMPL GSAVDILATD DPNFSPDDQQ DTQIYEKHDN
560 570 580 590 600
LLHGIKKKKE KMVSAAFMRK YIHVAKIIKP VLTQESAAYI AEEYSRLRSQ
610 620 630 640 650
DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ DAEEAVELVQ
660 670 680 690 700
YAYFKKVLEK EKKRKKRSED ESDAEDEVEK SQEDQEQKTK RRRICPSDAK
710 720 730 740 750
EGDSYDPYDF TNTEEEMPQV HTPKATDSQE TKESQKVELS ESRLKAFKAA
760 770 780 790 800
LLEVFREAHA QSVGMNRLTE SVNRDNEEPF SSAEIQAALS RMQDDNQVMV
SEGIVFLI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LZF0 | A0A3Q1LZF0_BOVIN | DNA helicase | MCM3 | 421 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC114737 mRNA Translation: AAI14738.1 |
RefSeqi | NP_001013604.2, NM_001013586.2 |
Genome annotation databases
Ensembli | ENSBTAT00000014194; ENSBTAP00000014194; ENSBTAG00000010721 |
GeneIDi | 281302 |
KEGGi | bta:281302 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC114737 mRNA Translation: AAI14738.1 |
RefSeqi | NP_001013604.2, NM_001013586.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000014194 |
Proteomic databases
PaxDbi | A4FUD9 |
PRIDEi | A4FUD9 |
Genome annotation databases
Ensembli | ENSBTAT00000014194; ENSBTAP00000014194; ENSBTAG00000010721 |
GeneIDi | 281302 |
KEGGi | bta:281302 |
Organism-specific databases
CTDi | 4172 |
VGNCi | VGNC:31309, MCM3 |
Phylogenomic databases
eggNOGi | KOG0479, Eukaryota |
GeneTreei | ENSGT01010000222249 |
InParanoidi | A4FUD9 |
OrthoDBi | 266497at2759 |
Gene expression databases
ExpressionAtlasi | A4FUD9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR031327, MCM IPR008046, Mcm3 IPR018525, MCM_CS IPR001208, MCM_dom IPR041562, MCM_lid IPR027925, MCM_N IPR033762, MCM_OB IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase |
PANTHERi | PTHR11630, PTHR11630, 1 hit |
Pfami | View protein in Pfam PF00493, MCM, 1 hit PF17855, MCM_lid, 1 hit PF14551, MCM_N, 1 hit PF17207, MCM_OB, 1 hit |
PRINTSi | PR01657, MCMFAMILY PR01659, MCMPROTEIN3 |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00350, MCM, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00847, MCM_1, 1 hit PS50051, MCM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCM3_BOVIN | |
Accessioni | A4FUD9Primary (citable) accession number: A4FUD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families