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Entry version 75 (29 Sep 2021)
Sequence version 1 (17 Apr 2007)
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Protein
Submitted name:

SNRNP200 protein

Gene

SNRNP200

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SNRNP200 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNRNP200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A4FU77

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A4FU77, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini241 – 424Helicase ATP-bindingInterPro annotationAdd BLAST184
Domaini435 – 672Helicase C-terminalInterPro annotationAdd BLAST238
Domaini1088 – 1263Helicase ATP-bindingInterPro annotationAdd BLAST176
Domaini1296 – 1504Helicase C-terminalInterPro annotationAdd BLAST209

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. SKI2 subfamily.ARBA annotation

Keywords - Domaini

RepeatARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 2 hits
2.60.40.150, 2 hits
3.40.50.300, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041094, Brr2_helicase_PWI
IPR035892, C2_domain_sf
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR014756, Ig_E-set
IPR027417, P-loop_NTPase
IPR004179, Sec63-dom
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 2 hits
PF00271, Helicase_C, 1 hit
PF18149, Helicase_PWI, 1 hit
PF02889, Sec63, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 2 hits
SM00490, HELICc, 2 hits
SM00973, Sec63, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 2 hits
SSF52540, SSF52540, 4 hits
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 2 hits
PS51194, HELICASE_CTER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A4FU77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LMSSKKKDLH PRDIDAFWLQ RQLSRFYDDA IVSQKKADEV LEILKTASDD
60 70 80 90 100
RECENQLVLL LGFNTFDFIK VLRQHRMMIL YCTLLASAQS EAEKERIMGK
110 120 130 140 150
MEADPELSKF LYQLHETEKE DLIREERSRR ERVRQSRMDT DLETMDLDQG
160 170 180 190 200
GEALAPRQVL DLEDLVFTQG SHFMANKRCQ LPDGSFRRQR KGYEEVHVPA
210 220 230 240 250
LKPKPFGSEE QLLPVEKLPK YAQAGFEGFK TLNRIQSKLY RAALETDENL
260 270 280 290 300
LLCAPTGAGK TNVALMCMLR EIGKHINMDG TINVDDFKII YIAPMRSLVQ
310 320 330 340 350
EMVGSFGKRL ATYGITVAEL TGDHQLCKEE ISATQIIVCT PEKWDIITRK
360 370 380 390 400
GGERTYTQLV RLIILDEIHL LHDDRGPVLE ALVARAIRNI EMTQEDVRLI
410 420 430 440 450
GLSATLPNYE DVATFLRVDP AKGLFYFDNS FRPVPLEQTY VGITEKKAIK
460 470 480 490 500
RFQIMNEIVY EKIMEHAGKN QVLVFVHSRK ETGKTARAIR DMCLEKDTLG
510 520 530 540 550
LFLREGSAST EVLRTEAEQC KNLELKDLLP YGFAIHHAGM TRVDRTLVED
560 570 580 590 600
LFADKHIQVL VSTATLAWGV NLPAHTVIIK GTQVYSPEKG RWTELGALDI
610 620 630 640 650
LQMLGRAGRP QYDTKGEGIL ITSHGELQYY LSLLNQQLPI ESQMVSKLPD
660 670 680 690 700
MLNAEIVLGN VQNAKDAVNW LGYAYLYIRM LRSPTLYGIS HDDLKGDPLL
710 720 730 740 750
DQRRLDLVHT AALMLDKNNL VKYDKKTGNF QVTELGRIAS HYYITNDTVQ
760 770 780 790 800
TYNQLLKPTL SEIELFRVFS LSSEFKNITV REEEKLELQK LLERVPIPVK
810 820 830 840 850
ESIEEPSAKI NVLLQAFISQ LKLEGFALMA DMVYVTQSAG RLMRAIFEIV
860 870 880 890 900
LNRGWAQLTD KTLNLCKMID KRMWQSMCPL RQFRKLPEEV VKKIEKKNFP
910 920 930 940 950
FERLYDLNHN EIGELIRMPK MGKTIHKYVH LFPKLELSVH LQPITRSTLK
960 970 980 990 1000
VELTITPDFQ WDEKVHGSSE AFWILVEDVD SEVILHHEYF LLKAKYAQDE
1010 1020 1030 1040 1050
HLITFFVPVF EPLPPQYFIR VVSDRWLSCE TQLPVSFRHL ILPEKYPPPT
1060 1070 1080 1090 1100
ELLDLQPLPV SALRNSAFES LYQDKFPFFN PIQTQVFNTV YNSDDNVFVG
1110 1120 1130 1140 1150
APTGSGKTIC AEFAILRMLL QSSEGRCVYI TPMEALAEQV YMDWYEKFQD
1160 1170 1180 1190 1200
RLNKKVVLLT GETSTDLKLL GKGNIIISTP EKWDILSRRW KQRKNVQNIN
1210 1220 1230 1240 1250
LFVVDEVHLI GGENGPVLEV ICSRMRYISS QIERPIRIVA LSSSLSNAKD
1260 1270 1280 1290 1300
VAHWLGCSAT STFNFHPNVR PVPLELHIQG FNISHTQTRL LSMAKPVYHA
1310 1320 1330 1340 1350
ITKHSPKKPV IVFVPSRKQT RLTAIDILTT CAADIQRQRF LHCTEKDLIP
1360 1370 1380 1390 1400
YLEKLSDSTL KETLLNGVGY LHEGLSPMER RLVEQLFSSG AIQVVVASRS
1410 1420 1430 1440 1450
LCWGMNVAAH LVIIMDTQYY NGKIHAYVDY PIYDVLQMVG HANRPLQDDE
1460 1470 1480 1490 1500
GRCVIMCQGS KKDFFKKFLY EPLPVESHLD HCMHDHFNAE IVTKTIENKQ
1510 1520 1530 1540 1550
DAVDYLTWTF LYRRMTQNPN YYNLQGISHR HLSDHLSELV EQTLSDLEQS
1560 1570 1580 1590 1600
KCISIEDEMD VAPLNLGMIA AYYYINYTTI ELFSMSLNAK TKVRGLIEII
1610 1620 1630 1640 1650
SNAAEYENIP IRHHEDNLLR QLAQKVPHKL NNPKFNDPHV KTNLLLQAHL
1660 1670 1680 1690 1700
SRMQLSAELQ SDTEEILSKA IRLIQACVDV LSSNGWLSPA LAAMELAQMV
1710 1720 1730 1740 1750
TQAMWSKDSY LKQLPHFTSE HIKRCTDKGV ESVFDIMEME DEERNALLQL
1760 1770 1780 1790 1800
TDSQIADVAR FCNRYPNIEL SYEVVDKDSI RSGGPVVVLV QLEREEEVTG
1810 1820 1830 1840 1850
PVIAPLFPQK REEGWWVVIG DAKSNSLISI KRLTLQQKAK VKLDFVAPAT
1860 1870 1880
GAHNYTLYFM SDAYMGCDQE YKFSVDVKEA ETDSDSD
Length:1,887
Mass (Da):216,183
Last modified:April 17, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC0BF62535DA3894
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC112891 mRNA Translation: AAI12892.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC112891 mRNA Translation: AAI12892.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA4FU77, 2 interactors

Proteomic databases

PeptideAtlasiA4FU77

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SNRNP200, human

Family and domain databases

Gene3Di1.10.10.10, 2 hits
2.60.40.150, 2 hits
3.40.50.300, 4 hits
InterProiView protein in InterPro
IPR041094, Brr2_helicase_PWI
IPR035892, C2_domain_sf
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR014756, Ig_E-set
IPR027417, P-loop_NTPase
IPR004179, Sec63-dom
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF00270, DEAD, 2 hits
PF00271, Helicase_C, 1 hit
PF18149, Helicase_PWI, 1 hit
PF02889, Sec63, 2 hits
SMARTiView protein in SMART
SM00487, DEXDc, 2 hits
SM00490, HELICc, 2 hits
SM00973, Sec63, 2 hits
SUPFAMiSSF46785, SSF46785, 2 hits
SSF52540, SSF52540, 4 hits
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 2 hits
PS51194, HELICASE_CTER, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4FU77_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4FU77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 29, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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