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Entry version 100 (08 May 2019)
Sequence version 3 (31 Oct 2012)
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Protein

EF-hand calcium-binding domain-containing protein 5

Gene

EFCAB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi882 – 893PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EFCAB5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24801 EFCAB5

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A4FU69

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000176927

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145008457

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EFCAB5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003158361 – 1503EF-hand calcium-binding domain-containing protein 5Add BLAST1503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A4FU69

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A4FU69

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4FU69

PRoteomics IDEntifications database

More...
PRIDEi
A4FU69

ProteomicsDB human proteome resource

More...
ProteomicsDBi
669
670 [A4FU69-2]
671 [A4FU69-3]
672 [A4FU69-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A4FU69

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A4FU69

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176927 Expressed in 94 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A4FU69 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4FU69 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131921, 3 interactors

Protein interaction database and analysis system

More...
IntActi
A4FU69, 2 interactors

Molecular INTeraction database

More...
MINTi
A4FU69

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378312

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini869 – 904EF-handPROSITE-ProRule annotationAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IECF Eukaryota
ENOG410YZ07 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154049

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015239

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4FU69

Identification of Orthologs from Complete Genome Data

More...
OMAi
SCIFRDF

Database of Orthologous Groups

More...
OrthoDBi
1482025at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A4FU69

TreeFam database of animal gene trees

More...
TreeFami
TF329659

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.450.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR029016 GAF-like_dom_sf

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A4FU69-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNESASQEEL RPAQENRKED KERKWNLTEV KELHETLQSV PDVPVKEDTN
60 70 80 90 100
SVVEKAMDEI KSQELNLEGQ RKISPGSIKD SKTEASGNIA IRKSAKVIFA
110 120 130 140 150
LDETELKSKP EHTWKKNLFE RMEARAQAMQ QKIIDKENLK KELEKKAEKK
160 170 180 190 200
LPRDNLAKEW FNTDSMTLNN TAYLLDKLLP TLVPGVENML TQVEKKKVLT
210 220 230 240 250
EADTPSKFDP INYLGEYLIR NNPNYIKDPG MSGYQRLMKE VTEDLKIYVP
260 270 280 290 300
DTICNRVSKM KENVKQNRKQ RESIDKIIVK VANTRKQALQ EQFDEWILDP
310 320 330 340 350
KGMIPKSVIQ NVLQEFFQNP DFKLGSHCKQ LDITDSTEPR LNKMEFTEYI
360 370 380 390 400
SSHIKDLKSE MFEELLKHLC HSADEFREVI KADMRRQMFA ELFLHCDHGK
410 420 430 440 450
VGFLDRQRTL ALLELFYDHS SQMLRSLLRN PRQWPFIEFE EINLTELWGD
460 470 480 490 500
MDNQKHIYEG FDKVLLEMNT LLSANHASKT QSKLLESPDQ PKLNEQRTST
510 520 530 540 550
PSPNPPEQQR GVTAEQGPQR ISIEEQQQGK KPTAEQELYI ESVIEPGTHT
560 570 580 590 600
ESTLEQGSSR RLLTEQETHR ESTTEQGQHK GSIEGQGPRR VSVSEQGSSR
610 620 630 640 650
ESVAEQGSRR ESIAEQDRHK GSVAEQGSRR MSAAEQGSLR ESVIEEPYQK
660 670 680 690 700
SEQGPYGEII SEEQEDIGST SQSRKDSILK STKYGEPITS EYIEVPLQEK
710 720 730 740 750
RSWEQTYEEE IFLSSELQEE VPTLSRKDHF PETTKKEVQK DKPCEPKSQK
760 770 780 790 800
IEGKSWSGEF FTCNWKMKYV TFEDEEQANL IYGNSRFTDL HSIIRNIQSC
810 820 830 840 850
KEVKGRTAFN GVSFNLLQFV QLLETFVGED APLSVSETLT SFFKEGYVET
860 870 880 890 900
EQEKMNALEQ FSQNAFQVRQ RLLLEAIFQK WDSDGSGFLD LKEVDELLYT
910 920 930 940 950
YKEGMEKESM KKAKLHIQFP KPHPGHEVRL SSKQFQNYIE LVVSELRGNE
960 970 980 990 1000
DQVLESVVEF LMNALERSHI ESLRNSARRK WLHQIQCAAE TSGVSLEPVY
1010 1020 1030 1040 1050
SETFKALMQD AEAHGNKKIS AHISLLEENL LLPEKGNVLL RNVACTLDDA
1060 1070 1080 1090 1100
QFVLNRVLYR DMKGISFTVV DEGKPIHVPQ VQYHGNIFFW NQSRNKHDYN
1110 1120 1130 1140 1150
GSFLALPLQD AYMRIFGVLA VDTLRDPHEI NIFLPHEIRF YQGVANVFST
1160 1170 1180 1190 1200
AYHYVHSREH ILHIVITGIG WLYDVTSSIT SITTYFVEPS PAQDSDYVLR
1210 1220 1230 1240 1250
NMMVTGQLGL TEIHKNPPTI HRKSCIFRDF LFKCTDSSEV VLASACGETH
1260 1270 1280 1290 1300
IVVPLRERTG EALGVLDFNI GQNRMLLCQE YKDLQKMMKV VQVACYEILG
1310 1320 1330 1340 1350
EFSGEIKKKY ILEIENVREV QRAGILFFRI MLLELQESIQ LLNSMEFVSL
1360 1370 1380 1390 1400
LLYDHTLVTE PNSPQDSKSM ELEANVKLVR DILKAVILFF HPELEFSSDF
1410 1420 1430 1440 1450
GSWDKCKFYV NKYLVNNICA FDPTAKHVEV NVQLIDEYIR DHSRTEVWKF
1460 1470 1480 1490 1500
GNVVIEHLYH WIHICSALMK ITKQLNSGIT PPLPSKTDNY MYAKMPGEGL

QEK
Length:1,503
Mass (Da):173,404
Last modified:October 31, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i907EED07E7C17EB7
GO
Isoform 2 (identifier: A4FU69-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-926: AKLHIQFPKPHPGH → GLTLSPGWSAVAQL
     927-1503: Missing.

Show »
Length:926
Mass (Da):106,855
Checksum:iD0DEE537B4107202
GO
Isoform 3 (identifier: A4FU69-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     789-912: Missing.

Show »
Length:1,379
Mass (Da):159,092
Checksum:i850C9B1375349299
GO
Isoform 4 (identifier: A4FU69-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-1440: Missing.

Show »
Length:975
Mass (Da):112,739
Checksum:iB5845D5FA67F2A4D
GO
Isoform 5 (identifier: A4FU69-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     861-912: FSQNAFQVRQ...EGMEKESMKK → VSLCRQAGVQ...KFFPLETKFP
     913-1503: Missing.

Note: No experimental confirmation available.
Show »
Length:856
Mass (Da):98,992
Checksum:i5D6CC2569FB167D7
GO
Isoform 6 (identifier: A4FU69-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-343: Missing.
     861-912: FSQNAFQVRQ...EGMEKESMKK → VSLCRQAGVQ...KFFPLETKFP
     913-1503: Missing.

Note: No experimental confirmation available.
Show »
Length:569
Mass (Da):65,755
Checksum:i01E296A46B3AA225
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJC3K7EJC3_HUMAN
EF-hand calcium-binding domain-cont...
EFCAB5
774Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1E6C9J1E6_HUMAN
EF-hand calcium-binding domain-cont...
EFCAB5
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y843H0Y843_HUMAN
EF-hand calcium-binding domain-cont...
EFCAB5
1,185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4M1H0Y4M1_HUMAN
EF-hand calcium-binding domain-cont...
EFCAB5
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC87284 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324L → P in BX648689 (PubMed:14702039).Curated1
Sequence conflicti374D → E in BX648689 (PubMed:14702039).Curated1
Sequence conflicti429R → Q in BAC87284 (PubMed:15489334).Curated1
Sequence conflicti962M → I in BAC87284 (PubMed:15489334).Curated1
Sequence conflicti1386V → G in CAD38767 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038343237L → V1 PublicationCorresponds to variant dbSNP:rs9897794Ensembl.1
Natural variantiVAR_038344278I → K3 PublicationsCorresponds to variant dbSNP:rs4795524Ensembl.1
Natural variantiVAR_038345561R → S. Corresponds to variant dbSNP:rs9900546Ensembl.1
Natural variantiVAR_0486441145A → D. Corresponds to variant dbSNP:rs9894896Ensembl.1
Natural variantiVAR_0486451252V → A. Corresponds to variant dbSNP:rs4499292Ensembl.1
Natural variantiVAR_0486461274R → T. Corresponds to variant dbSNP:rs35724168Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0555101 – 343Missing in isoform 6. 1 PublicationAdd BLAST343
Alternative sequenceiVSP_0471841 – 56Missing in isoform 5. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_030732789 – 912Missing in isoform 3. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_047185861 – 912FSQNA…ESMKK → VSLCRQAGVQWRNCSSLQPP TPGLKRSSHHRLLSNWDYRE RRKFFPLETKFP in isoform 5 and isoform 6. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_047186913 – 1503Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST591
Alternative sequenceiVSP_030733913 – 1440Missing in isoform 4. 1 PublicationAdd BLAST528
Alternative sequenceiVSP_030734913 – 926AKLHI…PHPGH → GLTLSPGWSAVAQL in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_030735927 – 1503Missing in isoform 2. 1 PublicationAdd BLAST577

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128126 mRNA Translation: BAC87284.1 Different initiation.
AK299608 mRNA Translation: BAG61537.1
AK303060 mRNA Translation: BAG64177.1
BX648689 mRNA No translation available.
AL833911 mRNA Translation: CAD38767.1
AC104982 Genomic DNA No translation available.
AC104984 Genomic DNA No translation available.
AC104996 Genomic DNA No translation available.
BC110608 mRNA Translation: AAI10609.1
BC110609 mRNA Translation: AAI10610.1
BC119807 mRNA Translation: AAI19808.1
BC137519 mRNA Translation: AAI37520.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11254.2 [A4FU69-1]
CCDS54103.1 [A4FU69-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001138525.1, NM_001145053.1
NP_940931.2, NM_198529.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394835; ENSP00000378312; ENSG00000176927 [A4FU69-1]
ENST00000440741; ENSP00000393095; ENSG00000176927 [A4FU69-2]
ENST00000536908; ENSP00000440619; ENSG00000176927 [A4FU69-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
374786

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374786

UCSC genome browser

More...
UCSCi
uc002het.3 human [A4FU69-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128126 mRNA Translation: BAC87284.1 Different initiation.
AK299608 mRNA Translation: BAG61537.1
AK303060 mRNA Translation: BAG64177.1
BX648689 mRNA No translation available.
AL833911 mRNA Translation: CAD38767.1
AC104982 Genomic DNA No translation available.
AC104984 Genomic DNA No translation available.
AC104996 Genomic DNA No translation available.
BC110608 mRNA Translation: AAI10609.1
BC110609 mRNA Translation: AAI10610.1
BC119807 mRNA Translation: AAI19808.1
BC137519 mRNA Translation: AAI37520.1
CCDSiCCDS11254.2 [A4FU69-1]
CCDS54103.1 [A4FU69-5]
RefSeqiNP_001138525.1, NM_001145053.1
NP_940931.2, NM_198529.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi131921, 3 interactors
IntActiA4FU69, 2 interactors
MINTiA4FU69
STRINGi9606.ENSP00000378312

PTM databases

iPTMnetiA4FU69
PhosphoSitePlusiA4FU69

Polymorphism and mutation databases

BioMutaiEFCAB5

Proteomic databases

EPDiA4FU69
jPOSTiA4FU69
PaxDbiA4FU69
PRIDEiA4FU69
ProteomicsDBi669
670 [A4FU69-2]
671 [A4FU69-3]
672 [A4FU69-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394835; ENSP00000378312; ENSG00000176927 [A4FU69-1]
ENST00000440741; ENSP00000393095; ENSG00000176927 [A4FU69-2]
ENST00000536908; ENSP00000440619; ENSG00000176927 [A4FU69-5]
GeneIDi374786
KEGGihsa:374786
UCSCiuc002het.3 human [A4FU69-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
374786

GeneCards: human genes, protein and diseases

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GeneCardsi
EFCAB5

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013680
HGNCiHGNC:24801 EFCAB5
neXtProtiNX_A4FU69
OpenTargetsiENSG00000176927
PharmGKBiPA145008457

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IECF Eukaryota
ENOG410YZ07 LUCA
GeneTreeiENSGT00940000154049
HOGENOMiHOG000015239
InParanoidiA4FU69
OMAiSCIFRDF
OrthoDBi1482025at2759
PhylomeDBiA4FU69
TreeFamiTF329659

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EFCAB5 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
374786

Protein Ontology

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PROi
PR:A4FU69

Gene expression databases

BgeeiENSG00000176927 Expressed in 94 organ(s), highest expression level in testis
ExpressionAtlasiA4FU69 baseline and differential
GenevisibleiA4FU69 HS

Family and domain databases

Gene3Di3.30.450.40, 1 hit
InterProiView protein in InterPro
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR029016 GAF-like_dom_sf
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFCB5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4FU69
Secondary accession number(s): B2RPN0
, B4DS75, B4DZR5, F5GYL2, Q0VD68, Q6ZRM6, Q8NDG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 31, 2012
Last modified: May 8, 2019
This is version 100 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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