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UniProtKB - A4FU51 (A4FU51_HUMAN)

Entry version 121 (02 Dec 2020)
Sequence version 1 (17 Apr 2007)
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Protein
Submitted name:

NMDA receptor regulated 1-like

Gene

NARG1L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NMDA receptor regulated 1-likeImported
Submitted name:
NMDA receptor regulated 1-like, isoform CRA_cImported
Submitted name:
cDNA FLJ77538, highly similar to Homo sapiens NMDA receptor regulated 1-like (NARG1L), transcript variant 1, mRNAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NARG1LImported
ORF Names:hCG_2020106Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000172766.18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165505266

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172766, Expressed in sural nerve and 235 other tissues

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A4FU51

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 181TPR_REGIONInterPro annotationAdd BLAST136
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati46 – 79TPRPROSITE-ProRule annotationAdd BLAST34
Repeati80 – 113TPRPROSITE-ProRule annotationAdd BLAST34
Domaini224 – 257TPR_REGIONInterPro annotationAdd BLAST34
Repeati224 – 257TPRPROSITE-ProRule annotationAdd BLAST34
Domaini374 – 441TPR_REGIONInterPro annotationAdd BLAST68
Repeati374 – 407TPRPROSITE-ProRule annotationAdd BLAST34
Repeati408 – 441TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni603 – 638DisorderedSequence analysisAdd BLAST36

Keywords - Domaini

RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006686_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		VNHTAIN

Database of Orthologous Groups

More...OrthoDBi		792708at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR021183, NatA_aux_su
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR013105, TPR_2
IPR019734, TPR_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12569, NARP1, 1 hit
PF07719, TPR_2, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005, TPR, 5 hits
PS50293, TPR_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A4FU51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA 
        60         70         80         90        100
MKGLTLNCLG KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI 
       110        120        130        140        150
KCYRNALKLD KDNLQILRDL SLLQIQMRDL EGYRETRYQL LQLRPTQRAS 
       160        170        180        190        200
WIGYAIAYHL LKDYDMALKL LEEFRQTQQV PPNKIDYEYS ELILYQNQVM 
       210        220        230        240        250
READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL KEASEVFKNL 
       260        270        280        290        300
IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 
       310        320        330        340        350
VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE 
       360        370        380        390        400
ASLKTCDFFS PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA 
       410        420        430        440        450
IASTPTLIEL FYMKAKIYKH IGNLKEAAKW MDEAQSLDTA DRFINSKCAK 
       460        470        480        490        500
YMLRANMIKE AEEMCSKFTR EGTSAMENLN EMQCMWFQTE CISAYQRLGR 
       510        520        530        540        550
YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD LLRLEDILRR 
       560        570        580        590        600
HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR 
       610        620        630        640        650
RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV 
       660        670        680        690        700
ENPLEEAVKF LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA 
       710        720        730        740        750
INSNNPWLHE CLIRFSKSVS NHSNLPDIVS KVLSQEMQKI FVKKDLESFN 
       760        770        780        790        800
EDFLKRNATS LQHLLSGAKM MYFLDKSRQE KAIAIATRLD ETIKDKDVKT 
       810        820        830        840        850
LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA VNEVDNPNVA 
       860 
LNHTANYDVL ANEI
Length:864
Mass (Da):101,462
Last modified:April 17, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i510001EC0D9DD592
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC101719 mRNA Translation: AAI01720.1
BC101721 mRNA Translation: AAI01722.1
AK291248 mRNA Translation: BAF83937.1
CH471075 Genomic DNA Translation: EAX08656.1

NCBI Reference Sequences

More...RefSeqi		NP_078837.3, NM_024561.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79612

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79612

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101719 mRNA Translation: AAI01720.1
BC101721 mRNA Translation: AAI01722.1
AK291248 mRNA Translation: BAF83937.1
CH471075 Genomic DNA Translation: EAX08656.1
RefSeqiNP_078837.3, NM_024561.4

3D structure databases

SMRiA4FU51
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23410, 59 antibodies

The DNASU plasmid repository

More...DNASUi		79612

Genome annotation databases

GeneIDi79612
KEGGihsa:79612

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79612
EuPathDBiHostDB:ENSG00000172766.18
PharmGKBiPA165505266

Phylogenomic databases

HOGENOMiCLU_006686_0_0_1
OMAiVNHTAIN
OrthoDBi792708at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79612, 14 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NAA16, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79612

Gene expression databases

BgeeiENSG00000172766, Expressed in sural nerve and 235 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR021183, NatA_aux_su
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR013105, TPR_2
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF12569, NARP1, 1 hit
PF07719, TPR_2, 1 hit
PIRSFiPIRSF000422, N-terminal-AcTrfase-A_aux_su, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 6 hits
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005, TPR, 5 hits
PS50293, TPR_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA4FU51_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4FU51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 17, 2007
Last sequence update: April 17, 2007
Last modified: December 2, 2020
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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