UniProtKB - A4FU01 (MTMRB_HUMAN)
Protein
Myotubularin-related protein 11
Gene
MTMR11
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 375 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated
GO - Molecular functioni
- phosphatidylinositol-3-phosphatase activity Source: GO_Central
GO - Biological processi
- phosphatidylinositol dephosphorylation Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | A4FU01 |
Names & Taxonomyi
Protein namesi | Recommended name: Myotubularin-related protein 11Alternative name(s): Cisplatin resistance-associated protein Short name: hCRA Inactive phosphatidylinositol 3-phosphatase 11Curated |
Gene namesi | Name:MTMR11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000014914.19 |
HGNCi | HGNC:24307, MTMR11 |
neXtProti | NX_A4FU01 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 10903 |
OpenTargetsi | ENSG00000014914 |
PharmGKBi | PA142671303 |
Miscellaneous databases
Pharosi | A4FU01, Tdark |
Polymorphism and mutation databases
BioMutai | MTMR11 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337098 | 1 – 709 | Myotubularin-related protein 11Add BLAST | 709 |
Proteomic databases
EPDi | A4FU01 |
jPOSTi | A4FU01 |
MassIVEi | A4FU01 |
MaxQBi | A4FU01 |
PaxDbi | A4FU01 |
PeptideAtlasi | A4FU01 |
PRIDEi | A4FU01 |
ProteomicsDBi | 656 [A4FU01-1] 657 [A4FU01-2] 658 [A4FU01-3] 659 [A4FU01-4] 660 [A4FU01-5] 661 [A4FU01-6] |
PTM databases
DEPODi | MTMR11 |
iPTMneti | A4FU01 |
PhosphoSitePlusi | A4FU01 |
Expressioni
Tissue specificityi
Expressed in bone marrow, spleen and thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000014914, Expressed in transverse colon and 177 other tissues |
Genevisiblei | A4FU01, HS |
Organism-specific databases
HPAi | ENSG00000014914, Tissue enhanced (intestine) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116109, 18 interactors |
IntActi | A4FU01, 2 interactors |
MINTi | A4FU01 |
STRINGi | 9606.ENSP00000391668 |
Miscellaneous databases
RNActi | A4FU01, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 196 – 639 | Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST | 444 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1089, Eukaryota |
GeneTreei | ENSGT00940000160276 |
HOGENOMi | CLU_021912_1_0_1 |
InParanoidi | A4FU01 |
OMAi | GWQRSQD |
OrthoDBi | 620702at2759 |
PhylomeDBi | A4FU01 |
TreeFami | TF315197 |
Family and domain databases
InterProi | View protein in InterPro IPR030580, MTMR11 IPR022587, MTMR12-like_C IPR010569, Myotubularin-like_Pase_dom IPR030564, Myotubularin_fam IPR029021, Prot-tyrosine_phosphatase-like |
PANTHERi | PTHR10807, PTHR10807, 1 hit PTHR10807:SF51, PTHR10807:SF51, 1 hit |
Pfami | View protein in Pfam PF12578, 3-PAP, 1 hit PF06602, Myotub-related, 2 hits |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS51339, PPASE_MYOTUBULARIN, 1 hit |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: A4FU01-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWWGGRGQSF NIAPQKEEPE MGSVQENRMP EPRSRQPSSC LASRCLPGEQ
60 70 80 90 100
ILAWAPGVRK GLEPELSGTL ICTNFRVTFQ PCGWQWNQDT PLNSEYDFAL
110 120 130 140 150
VNIGRLEAVS GLSRVQLLRP GSLHKFIPEE ILIHGRDFRL LRVGFEAGGL
160 170 180 190 200
EPQAFQVTMA IVQARAQSNQ AQQYSGITLS KAGQGSGSRK PPIPLMETAE
210 220 230 240 250
DWETERKKQA ARGWRVSTVN ERFDVATSLP RYFWVPNRIL DSEVRRAFGH
260 270 280 290 300
FHQGRGPRLS WHHPGGSDLL RCGGFYTASD PNKEDIRAVE LMLQAGHSDV
310 320 330 340 350
VLVDTMDELP SLADVQLAHL RLRALCLPDS SVAEDKWLSA LEGTRWLDYV
360 370 380 390 400
RACLRKASDI SVLVTSRVRS VILQERGDRD LNGLLSSLVQ LLSAPEARTL
410 420 430 440 450
FGFQSLVQRE WVAAGHPFLT RLGGTGASEE APVFLLFLDC VWQLLQQFPA
460 470 480 490 500
DFEFSEFFLL ALHDSVRVPD TLTFLRNTPW ERGKQSGQLN SYTQVYTPGY
510 520 530 540 550
SQPPAGNSFN LQLSVWDWDL RYSNAQILQF QNPGYDPEHC PDSWLPRPQP
560 570 580 590 600
SFMVPGPPSS VWLFSRGALT PLNQLCPWRD SPSLLAVSSR WLPRPAISSE
610 620 630 640 650
SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIRLWRRCYL RGRPEVQMGL
660 670 680 690 700
SAPTISGLQD ELSHLQELLR KWTPRISPED HSKKRDPHTI LNPTEIAGIL
KGRAEGDLG
Isoform 2 (identifier: A4FU01-2) [UniParc]FASTAAdd to basket
Also known as: hCRA alpha
The sequence of this isoform differs from the canonical sequence as follows:
258-268: RLSWHHPGGSD → VSVMVRVMAVD
269-709: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Isoform 3 (identifier: A4FU01-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-28: Missing.
258-268: RLSWHHPGGSD → VSVMVRVMAVD
269-709: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Sequence cautioni
The sequence AAB36952 differs from that shown. Reason: Frameshift.Curated
The sequence AAB36953 differs from that shown. Reason: Frameshift.Curated
The sequence AAH94756 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | W → R in BAG60917 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 165 | R → G in BAG60917 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 263 | H → R in BAG53406 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043598 | 159 | M → V1 PublicationCorresponds to variant dbSNP:rs11205303Ensembl. | 1 | |
Natural variantiVAR_043599 | 531 | Q → P. Corresponds to variant dbSNP:rs16836857Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033883 | 1 – 72 | Missing in isoform 4. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_033884 | 1 – 28 | Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_033885 | 73 – 75 | TNF → MPP in isoform 4. 1 Publication | 3 | |
Alternative sequenceiVSP_033886 | 228 – 272 | SLPRY…DLLRC → RLRCFSSSLIVSGSSSSSFQ LILNSLSFSFLLFMTVSGFL TPLPS in isoform 5. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_033887 | 258 – 268 | RLSWHHPGGSD → VSVMVRVMAVD in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 11 | |
Alternative sequenceiVSP_033888 | 269 – 709 | Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST | 441 | |
Alternative sequenceiVSP_033889 | 273 – 709 | Missing in isoform 5. 1 PublicationAdd BLAST | 437 | |
Alternative sequenceiVSP_035725 | 375 – 382 | ERGDRDLN → GSGVSPLP in isoform 6. 1 Publication | 8 | |
Alternative sequenceiVSP_035726 | 383 – 709 | Missing in isoform 6. 1 PublicationAdd BLAST | 327 | |
Alternative sequenceiVSP_033890 | 703 – 709 | RAEGDLG → QSHPFWITRC in isoform 4. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78556 mRNA Translation: AAB36952.1 Frameshift. U78557 mRNA Translation: AAB36953.1 Frameshift. AK097000 mRNA Translation: BAG53406.1 AK296094 mRNA Translation: BAG58848.1 AK298775 mRNA Translation: BAG60917.1 AK304820 mRNA Translation: BAG65568.1 AL590487 Genomic DNA Translation: CAI12649.1 CH471121 Genomic DNA Translation: EAW53589.1 CH471121 Genomic DNA Translation: EAW53590.1 CH471121 Genomic DNA Translation: EAW53594.1 BC064372 mRNA No translation available. BC094756 mRNA Translation: AAH94756.1 Different initiation. BC100818 mRNA Translation: AAI00819.1 BC100819 mRNA Translation: AAI00820.1 BC100820 mRNA Translation: AAI00821.1 |
CCDSi | CCDS72901.1 [A4FU01-4] CCDS72902.1 [A4FU01-1] |
RefSeqi | NP_001139334.1, NM_001145862.1 [A4FU01-1] NP_870988.2, NM_181873.3 [A4FU01-4] |
Genome annotation databases
Ensembli | ENST00000369140; ENSP00000358136; ENSG00000014914 [A4FU01-4] ENST00000439741; ENSP00000391668; ENSG00000014914 [A4FU01-1] |
GeneIDi | 10903 |
KEGGi | hsa:10903 |
UCSCi | uc001etl.5, human [A4FU01-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U78556 mRNA Translation: AAB36952.1 Frameshift. U78557 mRNA Translation: AAB36953.1 Frameshift. AK097000 mRNA Translation: BAG53406.1 AK296094 mRNA Translation: BAG58848.1 AK298775 mRNA Translation: BAG60917.1 AK304820 mRNA Translation: BAG65568.1 AL590487 Genomic DNA Translation: CAI12649.1 CH471121 Genomic DNA Translation: EAW53589.1 CH471121 Genomic DNA Translation: EAW53590.1 CH471121 Genomic DNA Translation: EAW53594.1 BC064372 mRNA No translation available. BC094756 mRNA Translation: AAH94756.1 Different initiation. BC100818 mRNA Translation: AAI00819.1 BC100819 mRNA Translation: AAI00820.1 BC100820 mRNA Translation: AAI00821.1 |
CCDSi | CCDS72901.1 [A4FU01-4] CCDS72902.1 [A4FU01-1] |
RefSeqi | NP_001139334.1, NM_001145862.1 [A4FU01-1] NP_870988.2, NM_181873.3 [A4FU01-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 116109, 18 interactors |
IntActi | A4FU01, 2 interactors |
MINTi | A4FU01 |
STRINGi | 9606.ENSP00000391668 |
PTM databases
DEPODi | MTMR11 |
iPTMneti | A4FU01 |
PhosphoSitePlusi | A4FU01 |
Polymorphism and mutation databases
BioMutai | MTMR11 |
Proteomic databases
EPDi | A4FU01 |
jPOSTi | A4FU01 |
MassIVEi | A4FU01 |
MaxQBi | A4FU01 |
PaxDbi | A4FU01 |
PeptideAtlasi | A4FU01 |
PRIDEi | A4FU01 |
ProteomicsDBi | 656 [A4FU01-1] 657 [A4FU01-2] 658 [A4FU01-3] 659 [A4FU01-4] 660 [A4FU01-5] 661 [A4FU01-6] |
Protocols and materials databases
Antibodypediai | 34015, 47 antibodies |
DNASUi | 10903 |
Genome annotation databases
Ensembli | ENST00000369140; ENSP00000358136; ENSG00000014914 [A4FU01-4] ENST00000439741; ENSP00000391668; ENSG00000014914 [A4FU01-1] |
GeneIDi | 10903 |
KEGGi | hsa:10903 |
UCSCi | uc001etl.5, human [A4FU01-1] |
Organism-specific databases
CTDi | 10903 |
DisGeNETi | 10903 |
EuPathDBi | HostDB:ENSG00000014914.19 |
GeneCardsi | MTMR11 |
HGNCi | HGNC:24307, MTMR11 |
HPAi | ENSG00000014914, Tissue enhanced (intestine) |
neXtProti | NX_A4FU01 |
OpenTargetsi | ENSG00000014914 |
PharmGKBi | PA142671303 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1089, Eukaryota |
GeneTreei | ENSGT00940000160276 |
HOGENOMi | CLU_021912_1_0_1 |
InParanoidi | A4FU01 |
OMAi | GWQRSQD |
OrthoDBi | 620702at2759 |
PhylomeDBi | A4FU01 |
TreeFami | TF315197 |
Enzyme and pathway databases
PathwayCommonsi | A4FU01 |
Miscellaneous databases
BioGRID-ORCSi | 10903, 7 hits in 845 CRISPR screens |
ChiTaRSi | MTMR11, human |
GenomeRNAii | 10903 |
Pharosi | A4FU01, Tdark |
PROi | PR:A4FU01 |
RNActi | A4FU01, protein |
Gene expression databases
Bgeei | ENSG00000014914, Expressed in transverse colon and 177 other tissues |
Genevisiblei | A4FU01, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030580, MTMR11 IPR022587, MTMR12-like_C IPR010569, Myotubularin-like_Pase_dom IPR030564, Myotubularin_fam IPR029021, Prot-tyrosine_phosphatase-like |
PANTHERi | PTHR10807, PTHR10807, 1 hit PTHR10807:SF51, PTHR10807:SF51, 1 hit |
Pfami | View protein in Pfam PF12578, 3-PAP, 1 hit PF06602, Myotub-related, 2 hits |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS51339, PPASE_MYOTUBULARIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MTMRB_HUMAN | |
Accessioni | A4FU01Primary (citable) accession number: A4FU01 Secondary accession number(s): B3KUE4 Q99753 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations