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UniProtKB - A4FU01 (MTMRB_HUMAN)

Entry version 110 (10 Feb 2021)
Sequence version 2 (20 May 2008)
Previous versions | rss
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Protein

Myotubularin-related protein 11

Gene

MTMR11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 375 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A4FU01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myotubularin-related protein 11
Alternative name(s):
Cisplatin resistance-associated protein
Short name:
hCRA
Inactive phosphatidylinositol 3-phosphatase 11Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTMR11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24307, MTMR11

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A4FU01

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000014914.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10903

Open Targets

More...OpenTargetsi		ENSG00000014914

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671303

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A4FU01, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MTMR11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370981 – 709Myotubularin-related protein 11Add BLAST709

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A4FU01

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A4FU01

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A4FU01

MaxQB - The MaxQuant DataBase

More...MaxQBi		A4FU01

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A4FU01

PeptideAtlas

More...PeptideAtlasi		A4FU01

PRoteomics IDEntifications database

More...PRIDEi		A4FU01

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		656 [A4FU01-1]
657 [A4FU01-2]
658 [A4FU01-3]
659 [A4FU01-4]
660 [A4FU01-5]
661 [A4FU01-6]

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		MTMR11

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A4FU01

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A4FU01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in bone marrow, spleen and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000014914, Expressed in transverse colon and 177 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A4FU01, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000014914, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116109, 18 interactors

Protein interaction database and analysis system

More...IntActi		A4FU01, 2 interactors

Molecular INTeraction database

More...MINTi		A4FU01

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000391668

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A4FU01, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini196 – 639Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST444

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1089, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160276

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021912_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A4FU01

Identification of Orthologs from Complete Genome Data

More...OMAi		GWQRSQD

Database of Orthologous Groups

More...OrthoDBi		620702at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A4FU01

TreeFam database of animal gene trees

More...TreeFami		TF315197

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030580, MTMR11
IPR022587, MTMR12-like_C
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like

The PANTHER Classification System

More...PANTHERi		PTHR10807, PTHR10807, 1 hit
PTHR10807:SF51, PTHR10807:SF51, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12578, 3-PAP, 1 hit
PF06602, Myotub-related, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A4FU01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWWGGRGQSF NIAPQKEEPE MGSVQENRMP EPRSRQPSSC LASRCLPGEQ 
        60         70         80         90        100
ILAWAPGVRK GLEPELSGTL ICTNFRVTFQ PCGWQWNQDT PLNSEYDFAL 
       110        120        130        140        150
VNIGRLEAVS GLSRVQLLRP GSLHKFIPEE ILIHGRDFRL LRVGFEAGGL 
       160        170        180        190        200
EPQAFQVTMA IVQARAQSNQ AQQYSGITLS KAGQGSGSRK PPIPLMETAE 
       210        220        230        240        250
DWETERKKQA ARGWRVSTVN ERFDVATSLP RYFWVPNRIL DSEVRRAFGH 
       260        270        280        290        300
FHQGRGPRLS WHHPGGSDLL RCGGFYTASD PNKEDIRAVE LMLQAGHSDV 
       310        320        330        340        350
VLVDTMDELP SLADVQLAHL RLRALCLPDS SVAEDKWLSA LEGTRWLDYV 
       360        370        380        390        400
RACLRKASDI SVLVTSRVRS VILQERGDRD LNGLLSSLVQ LLSAPEARTL 
       410        420        430        440        450
FGFQSLVQRE WVAAGHPFLT RLGGTGASEE APVFLLFLDC VWQLLQQFPA 
       460        470        480        490        500
DFEFSEFFLL ALHDSVRVPD TLTFLRNTPW ERGKQSGQLN SYTQVYTPGY 
       510        520        530        540        550
SQPPAGNSFN LQLSVWDWDL RYSNAQILQF QNPGYDPEHC PDSWLPRPQP 
       560        570        580        590        600
SFMVPGPPSS VWLFSRGALT PLNQLCPWRD SPSLLAVSSR WLPRPAISSE 
       610        620        630        640        650
SLADQEWGLP SHWGACPLPP GLLLPGYLGP QIRLWRRCYL RGRPEVQMGL 
       660        670        680        690        700
SAPTISGLQD ELSHLQELLR KWTPRISPED HSKKRDPHTI LNPTEIAGIL 

KGRAEGDLG
Length:709
Mass (Da):79,545
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC07581E26364D1F
GO
Isoform 2 (identifier: A4FU01-2) [UniParc]FASTAAdd to basket
Also known as: hCRA alpha

The sequence of this isoform differs from the canonical sequence as follows:
     258-268: RLSWHHPGGSD → VSVMVRVMAVD
     269-709: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:268
Mass (Da):30,116
Checksum:i3767F7815C94AAE0
GO
Isoform 3 (identifier: A4FU01-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     258-268: RLSWHHPGGSD → VSVMVRVMAVD
     269-709: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:240
Mass (Da):26,885
Checksum:iE8D6FA7FD8657504
GO
Isoform 4 (identifier: A4FU01-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.
     73-75: TNF → MPP
     703-709: RAEGDLG → QSHPFWITRC

Show »
Length:640
Mass (Da):72,117
Checksum:iDB67312F79750231
GO
Isoform 5 (identifier: A4FU01-5) [UniParc]FASTAAdd to basket
Also known as: hCRA beta

The sequence of this isoform differs from the canonical sequence as follows:
     228-272: SLPRYFWVPN...HPGGSDLLRC → RLRCFSSSLI...VSGFLTPLPS
     273-709: Missing.

Show »
Length:272
Mass (Da):30,195
Checksum:i24FE481676EF146D
GO
Isoform 6 (identifier: A4FU01-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     375-382: ERGDRDLN → GSGVSPLP
     383-709: Missing.

Show »
Length:354
Mass (Da):39,372
Checksum:i2032989C2E856CAA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB36952 differs from that shown. Reason: Frameshift.Curated
The sequence AAB36953 differs from that shown. Reason: Frameshift.Curated
The sequence AAH94756 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86W → R in BAG60917 (PubMed:14702039).Curated1
Sequence conflicti165R → G in BAG60917 (PubMed:14702039).Curated1
Sequence conflicti263H → R in BAG53406 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043598159M → V1 PublicationCorresponds to variant dbSNP:rs11205303Ensembl.1
Natural variantiVAR_043599531Q → P. Corresponds to variant dbSNP:rs16836857Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0338831 – 72Missing in isoform 4. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_0338841 – 28Missing in isoform 3 and isoform 6. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_03388573 – 75TNF → MPP in isoform 4. 1 Publication3
Alternative sequenceiVSP_033886228 – 272SLPRY…DLLRC → RLRCFSSSLIVSGSSSSSFQ LILNSLSFSFLLFMTVSGFL TPLPS in isoform 5. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_033887258 – 268RLSWHHPGGSD → VSVMVRVMAVD in isoform 2 and isoform 3. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_033888269 – 709Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST441
Alternative sequenceiVSP_033889273 – 709Missing in isoform 5. 1 PublicationAdd BLAST437
Alternative sequenceiVSP_035725375 – 382ERGDRDLN → GSGVSPLP in isoform 6. 1 Publication8
Alternative sequenceiVSP_035726383 – 709Missing in isoform 6. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_033890703 – 709RAEGDLG → QSHPFWITRC in isoform 4. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U78556 mRNA Translation: AAB36952.1 Frameshift.
U78557 mRNA Translation: AAB36953.1 Frameshift.
AK097000 mRNA Translation: BAG53406.1
AK296094 mRNA Translation: BAG58848.1
AK298775 mRNA Translation: BAG60917.1
AK304820 mRNA Translation: BAG65568.1
AL590487 Genomic DNA Translation: CAI12649.1
CH471121 Genomic DNA Translation: EAW53589.1
CH471121 Genomic DNA Translation: EAW53590.1
CH471121 Genomic DNA Translation: EAW53594.1
BC064372 mRNA No translation available.
BC094756 mRNA Translation: AAH94756.1 Different initiation.
BC100818 mRNA Translation: AAI00819.1
BC100819 mRNA Translation: AAI00820.1
BC100820 mRNA Translation: AAI00821.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS72901.1 [A4FU01-4]
CCDS72902.1 [A4FU01-1]

NCBI Reference Sequences

More...RefSeqi		NP_001139334.1, NM_001145862.1 [A4FU01-1]
NP_870988.2, NM_181873.3 [A4FU01-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369140; ENSP00000358136; ENSG00000014914 [A4FU01-4]
ENST00000439741; ENSP00000391668; ENSG00000014914 [A4FU01-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10903

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10903

UCSC genome browser

More...UCSCi		uc001etl.5, human [A4FU01-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78556 mRNA Translation: AAB36952.1 Frameshift.
U78557 mRNA Translation: AAB36953.1 Frameshift.
AK097000 mRNA Translation: BAG53406.1
AK296094 mRNA Translation: BAG58848.1
AK298775 mRNA Translation: BAG60917.1
AK304820 mRNA Translation: BAG65568.1
AL590487 Genomic DNA Translation: CAI12649.1
CH471121 Genomic DNA Translation: EAW53589.1
CH471121 Genomic DNA Translation: EAW53590.1
CH471121 Genomic DNA Translation: EAW53594.1
BC064372 mRNA No translation available.
BC094756 mRNA Translation: AAH94756.1 Different initiation.
BC100818 mRNA Translation: AAI00819.1
BC100819 mRNA Translation: AAI00820.1
BC100820 mRNA Translation: AAI00821.1
CCDSiCCDS72901.1 [A4FU01-4]
CCDS72902.1 [A4FU01-1]
RefSeqiNP_001139334.1, NM_001145862.1 [A4FU01-1]
NP_870988.2, NM_181873.3 [A4FU01-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116109, 18 interactors
IntActiA4FU01, 2 interactors
MINTiA4FU01
STRINGi9606.ENSP00000391668

PTM databases

DEPODiMTMR11
iPTMnetiA4FU01
PhosphoSitePlusiA4FU01

Genetic variation databases

BioMutaiMTMR11

Proteomic databases

EPDiA4FU01
jPOSTiA4FU01
MassIVEiA4FU01
MaxQBiA4FU01
PaxDbiA4FU01
PeptideAtlasiA4FU01
PRIDEiA4FU01
ProteomicsDBi656 [A4FU01-1]
657 [A4FU01-2]
658 [A4FU01-3]
659 [A4FU01-4]
660 [A4FU01-5]
661 [A4FU01-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34015, 47 antibodies

The DNASU plasmid repository

More...DNASUi		10903

Genome annotation databases

EnsembliENST00000369140; ENSP00000358136; ENSG00000014914 [A4FU01-4]
ENST00000439741; ENSP00000391668; ENSG00000014914 [A4FU01-1]
GeneIDi10903
KEGGihsa:10903
UCSCiuc001etl.5, human [A4FU01-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10903
DisGeNETi10903

GeneCards: human genes, protein and diseases

More...GeneCardsi		MTMR11
HGNCiHGNC:24307, MTMR11
HPAiENSG00000014914, Tissue enhanced (intestine)
neXtProtiNX_A4FU01
OpenTargetsiENSG00000014914
PharmGKBiPA142671303
VEuPathDBiHostDB:ENSG00000014914.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1089, Eukaryota
GeneTreeiENSGT00940000160276
HOGENOMiCLU_021912_1_0_1
InParanoidiA4FU01
OMAiGWQRSQD
OrthoDBi620702at2759
PhylomeDBiA4FU01
TreeFamiTF315197

Enzyme and pathway databases

PathwayCommonsiA4FU01

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10903, 7 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MTMR11, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10903
PharosiA4FU01, Tdark

Protein Ontology

More...PROi		PR:A4FU01
RNActiA4FU01, protein

Gene expression databases

BgeeiENSG00000014914, Expressed in transverse colon and 177 other tissues
GenevisibleiA4FU01, HS

Family and domain databases

InterProiView protein in InterPro
IPR030580, MTMR11
IPR022587, MTMR12-like_C
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807, PTHR10807, 1 hit
PTHR10807:SF51, PTHR10807:SF51, 1 hit
PfamiView protein in Pfam
PF12578, 3-PAP, 1 hit
PF06602, Myotub-related, 2 hits
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTMRB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4FU01
Secondary accession number(s): B3KUE4
, B4DJI6, B4DQF5, B4E3Q6, Q3ZCP7, Q5SZ62, Q6P2Q8, Q99752, Q99753
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 10, 2021
This is version 110 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with genetic variants
    List of human entries with genetic variants
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