UniProtKB - A4D2J9 (A4D2J9_HUMAN)
Protein
Calcium/calmodulin-dependent protein kinase
Gene
CAMK2B
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Calmodulin-bindingARBA annotation, KinaseImported, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | A4D2J9 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium/calmodulin-dependent protein kinaseARBA annotation (EC:2.7.11.17ARBA annotation) |
Gene namesi | Name:CAMK2BImported ORF Names:tcag7.799Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000058404.19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000058404, Expressed in caudate nucleus and 188 other tissues |
ExpressionAtlasi | A4D2J9, baseline and differential |
Genevisiblei | A4D2J9, HS |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | A4D2J9, 1 interactor |
Chemistry databases
BindingDBi | A4D2J9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 272 | Protein kinaseInterPro annotationAdd BLAST | 259 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 349 – 534 | DisorderedSequence analysisAdd BLAST | 186 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 350 – 368 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 430 – 446 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 511 – 530 | Pro-richSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.ARBA annotation
Phylogenomic databases
OMAi | CIAYTRL |
OrthoDBi | 330091at2759 |
PhylomeDBi | A4D2J9 |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A4D2J9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTVTCTRF TDEYQLYEDI GKGAFSVVRR CVKLCTGHEY AAKIINTKKL
60 70 80 90 100
SARDHQKLER EARICRLLKH SNIVRLHDSI SEEGFHYLVF DLVTGGELFE
110 120 130 140 150
DIVAREYYSE ADASHCIQQI LEAVLHCHQM GVVHRDLKPE NLLLASKCKG
160 170 180 190 200
AAVKLADFGL AIEVQGDQQA WFGFAGTPGY LSPEVLRKEA YGKPVDIWAC
210 220 230 240 250
GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT VTPEAKNLIN
260 270 280 290 300
QMLTINPAKR ITAHEALKHP WVCQRSTVAS MMHRQETVEC LKKFNARRKL
310 320 330 340 350
KGAILTTMLA TRNFSVGRQT TAPATMSTAA SGTTMGLVEQ AKSLLNKKAD
360 370 380 390 400
GVKPQTNSTK NSAAATSPKG TLPPAALEPQ TTVIHNPVDG IKESSDSANT
410 420 430 440 450
TIEDEDAKAP RVPDILSSVR RGSGAPEAEG PLPCPSPAPF SPLPAPSPRI
460 470 480 490 500
SDILNSVRRG SGTPEAEGPL SAGPPPCLSP ALLGPLSSPS PRISDILNSV
510 520 530 540 550
RRGSGTPEAE GPSPVGPPPC PSPTIPGPLP TPSRKQEIIK TTEQLIEAVN
560 570 580 590 600
NGDFEAYAKI CDPGLTSFEP EALGNLVEGM DFHRFYFENL LAKNSKPIHT
610 620 630 640 650
TILNPHVHVI GEDAACIAYI RLTQYIDGQG RPRTSQSEET RVWHRRDGKW
660
QNVHFHCSGA PVAPLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH236960 Genomic DNA Translation: EAL23755.1 |
RefSeqi | NP_001211.3, NM_001220.4 |
Genome annotation databases
GeneIDi | 816 |
KEGGi | hsa:816 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH236960 Genomic DNA Translation: EAL23755.1 |
RefSeqi | NP_001211.3, NM_001220.4 |
3D structure databases
SMRi | A4D2J9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A4D2J9, 1 interactor |
Chemistry databases
BindingDBi | A4D2J9 |
Protocols and materials databases
Antibodypediai | 3482, 519 antibodies |
DNASUi | 816 |
Genome annotation databases
GeneIDi | 816 |
KEGGi | hsa:816 |
Organism-specific databases
CTDi | 816 |
PharmGKBi | PA91 |
VEuPathDBi | HostDB:ENSG00000058404.19 |
Phylogenomic databases
OMAi | CIAYTRL |
OrthoDBi | 330091at2759 |
PhylomeDBi | A4D2J9 |
Enzyme and pathway databases
SignaLinki | A4D2J9 |
Miscellaneous databases
BioGRID-ORCSi | 816, 10 hits in 904 CRISPR screens |
ChiTaRSi | CAMK2B, human |
GenomeRNAii | 816 |
Gene expression databases
Bgeei | ENSG00000058404, Expressed in caudate nucleus and 188 other tissues |
ExpressionAtlasi | A4D2J9, baseline and differential |
Genevisiblei | A4D2J9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013543, Ca/CaM-dep_prot_kinase-assoc IPR011009, Kinase-like_dom_sf IPR032710, NTF2-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF08332, CaMKII_AD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF54427, SSF54427, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4D2J9_HUMAN | |
Accessioni | A4D2J9Primary (citable) accession number: A4D2J9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | February 10, 2021 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |