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Protein

Olfactory receptor 2A25

Gene

OR2A25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2A25
Alternative name(s):
Olfactory receptor 2A27
Gene namesi
Name:OR2A25
Synonyms:OR2A25P, OR2A27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000221933.2
HGNCiHGNC:19562 OR2A25
neXtProtiNX_A4D2G3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 195ExtracellularSequence analysisAdd BLAST38
Transmembranei196 – 218Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 310CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi392138
PharmGKBiPA134892120

Polymorphism and mutation databases

BioMutaiOR2A25

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002937181 – 310Olfactory receptor 2A25Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA4D2G3
PRIDEiA4D2G3
ProteomicsDBi646

PTM databases

iPTMnetiA4D2G3
PhosphoSitePlusiA4D2G3

Expressioni

Gene expression databases

CleanExiHS_OR2A25
ExpressionAtlasiA4D2G3 baseline and differential

Organism-specific databases

HPAiHPA058272

Interactioni

Protein-protein interaction databases

BioGridi134111, 1 interactor
STRINGi9606.ENSP00000386167

Structurei

3D structure databases

ProteinModelPortaliA4D2G3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIT7 Eukaryota
ENOG41118P9 LUCA
GeneTreeiENSGT00820000127003
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiA4D2G3
KOiK04257
OMAiCAILKIQ
OrthoDBiEOG091G0CU6
PhylomeDBiA4D2G3
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A4D2G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGNQTSITE FLLLGFPIGP RIQMLLFGLF SLFYIFILLG NGTILGLISL
60 70 80 90 100
DSRLHTPMYF FLSHLAVVDI ACACSTVPQM LVNLLHPAKP ISFAGCMTQM
110 120 130 140 150
FLFLSFAHTE CLLLVVMSYD RYVAICHPLR YSTIMTWKVC ITLALTSWIL
160 170 180 190 200
GVLLALVHLV LLLPLSFCGP QKLNHFFCEI MAVLKLACAD THINEVMVLA
210 220 230 240 250
GAVSVLVGAF FSTVISYVHI LCAILKIQSG EGCQKAFSIC SSHLCVVGLF
260 270 280 290 300
YGTAIIMYVE PQYESPKEQK KYLLLFHSLF NPMLNPLIYS LRNKEVQGTL
310
KRMLEKKRTS
Length:310
Mass (Da):34,606
Last modified:March 24, 2009 - v2
Checksum:i57E11DC1FFF050B3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05466475S → N1 PublicationCorresponds to variant dbSNP:rs6951485Ensembl.1
Natural variantiVAR_054665209A → P1 PublicationCorresponds to variant dbSNP:rs2961135Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091768 Genomic DNA No translation available.
CH236959 Genomic DNA Translation: EAL23797.1
BC136814 mRNA Translation: AAI36815.1
BC136829 mRNA Translation: AAI36830.1
CCDSiCCDS43669.1
RefSeqiNP_001004488.1, NM_001004488.1
UniGeneiHs.553787

Genome annotation databases

EnsembliENST00000408898; ENSP00000386167; ENSG00000221933
ENST00000641441; ENSP00000493159; ENSG00000221933
ENST00000641663; ENSP00000493343; ENSG00000221933
GeneIDi392138
KEGGihsa:392138
UCSCiuc011ktx.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO2A25_HUMAN
AccessioniPrimary (citable) accession number: A4D2G3
Secondary accession number(s): B2RNC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 24, 2009
Last modified: June 20, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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