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UniProtKB - A4D2B0 (MBLC1_HUMAN)

>sp|A4D2B0|MBLC1_HUMAN Metallo-beta-lactamase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBLAC1 PE=1 SV=1
MRTEPLCGASPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQTRGPASSHRE
SPRGSGGAEAALEEAARGPILVDTGGPWAREALLGALAGQGVAPGDVTLVVGTHGHSDHI
GNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGPGLEVWATPGHGGQRDVSVVVA
GTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRKRVLVVADVVVPGHGPPFRVLRE
ASQPETEGGGNSQQEPVVGDEEPALH

Entry version 103 (29 Sep 2021)
Sequence version 1 (03 Apr 2007)
Previous versions | rss

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Protein

Metallo-beta-lactamase domain-containing protein 1

Gene

MBLAC1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380).

Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380).

May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380).

1 Publication

Cofactorⁱ

Zn²⁺1 PublicationNote: Binds 2 Zn²⁺ ions per subunit.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	114	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	116	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	118	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	119	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	169	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	192	Zinc 1Combined sources1 Publication	1
Metal bindingⁱ	192	Zinc 2Combined sources1 Publication	1
Metal bindingⁱ	231	Zinc 2Combined sources1 Publication	1

GO - Molecular functionⁱ

hydrolase activity Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	A4D2B0

PathwayCommonsⁱ

A4D2B0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metallo-beta-lactamase domain-containing protein 1 (EC:3.1.27.-1 Publication) Alternative name(s): Endoribonuclease MBLAC11 Publication
Gene namesⁱ	Name:MBLAC1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:22180, MBLAC1
neXtProtⁱ	NX_A4D2B0
VEuPathDBⁱ	HostDB:ENSG00000214309

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	169	H → A: Loss of endoribonuclease activity; when associated with A-192 and A-231. 1 Publication	1
Mutagenesisⁱ	192	D → A: Loss of endoribonuclease activity; when associated with A-169 and A-231. 1 Publication	1
Mutagenesisⁱ	231	H → A: Loss of endoribonuclease activity; when associated with A-169 and A-192. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	255374
PharmGKBⁱ	PA164722227

Miscellaneous databases

Pharosⁱ	A4D2B0, Tdark

Pharosⁱ

A4D2B0, Tdark

Genetic variation databases

BioMutaⁱ	MBLAC1

BioMutaⁱ

MBLAC1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000337027	1 – 266	Metallo-beta-lactamase domain-containing protein 1Add BLAST		266

Proteomic databases

EPDⁱ	A4D2B0
jPOSTⁱ	A4D2B0
MassIVEⁱ	A4D2B0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A4D2B0
PaxDbⁱ	A4D2B0
PeptideAtlas More...PeptideAtlasⁱ	A4D2B0
PRIDEⁱ	A4D2B0
ProteomicsDBⁱ	642

PTM databases

iPTMnetⁱ	A4D2B0
PhosphoSitePlusⁱ	A4D2B0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000214309, Expressed in cerebellum and 153 other tissues
ExpressionAtlasⁱ	A4D2B0, baseline and differential
Genevisibleⁱ	A4D2B0, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000214309, Low tissue specificity

HPAⁱ

ENSG00000214309, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Homodimer.

1 Publication

Protein-protein interaction databases

BioGRIDⁱ	129099, 15 interactors
IntActⁱ	A4D2B0, 3 interactors
STRINGⁱ	9606.ENSP00000381150

Miscellaneous databases

RNActⁱ	A4D2B0, protein

RNActⁱ

A4D2B0, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	8 – 14	Combined sources	7
Beta strandⁱ	16 – 25	Combined sources	10
Beta strandⁱ	28 – 31	Combined sources	4
Beta strandⁱ	33 – 36	Combined sources	4
Beta strandⁱ	38 – 41	Combined sources	4
Beta strandⁱ	44 – 49	Combined sources	6
Helixⁱ	68 – 75	Combined sources	8
Beta strandⁱ	80 – 82	Combined sources	3
Helixⁱ	87 – 89	Combined sources	3
Helixⁱ	90 – 99	Combined sources	10
Helixⁱ	104 – 106	Combined sources	3
Beta strandⁱ	109 – 114	Combined sources	6
Turnⁱ	117 – 119	Combined sources	3
Helixⁱ	123 – 125	Combined sources	3
Beta strandⁱ	129 – 133	Combined sources	5
Beta strandⁱ	136 – 139	Combined sources	4
Turnⁱ	140 – 142	Combined sources	3
Beta strandⁱ	155 – 158	Combined sources	4
Beta strandⁱ	161 – 165	Combined sources	5
Beta strandⁱ	168 – 171	Combined sources	4
Beta strandⁱ	175 – 182	Combined sources	8
Beta strandⁱ	185 – 191	Combined sources	7
Turnⁱ	200 – 202	Combined sources	3
Helixⁱ	204 – 206	Combined sources	3
Helixⁱ	210 – 223	Combined sources	14
Beta strandⁱ	225 – 229	Combined sources	5

Show more details

3D structure databases

SMRⁱ	A4D2B0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	48 – 71	DisorderedSequence analysisAdd BLAST		24
Regionⁱ	229 – 266	DisorderedSequence analysisAdd BLAST		38

Domainⁱ

Contains four of the five characteristic MBL-fold metal-binding motifs, with two waters completing metal coordination.1 Publication

Sequence similaritiesⁱ

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4736, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016193
HOGENOMⁱ	CLU_030571_2_6_1
InParanoidⁱ	A4D2B0
OMAⁱ	QVWATPG
Database of Orthologous Groups More...OrthoDBⁱ	1139836at2759
PhylomeDBⁱ	A4D2B0
TreeFamⁱ	TF316508

Family and domain databases

Gene3Dⁱ	3.60.15.10, 1 hit
InterProⁱ	View protein in InterPro IPR039344, MBLAC1 IPR001279, Metallo-B-lactamas IPR036866, RibonucZ/Hydroxyglut_hydro
PANTHERⁱ	PTHR23200, PTHR23200, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00753, Lactamase_B, 1 hit
SMARTⁱ	View protein in SMART SM00849, Lactamase_B, 1 hit
SUPFAMⁱ	SSF56281, SSF56281, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

A4D2B0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRTEPLCGAS PLLVPGDPYS VVVLLQGYAE PEGVGDAVRA DGSVTLVLPQ 
        60         70         80         90        100
TRGPASSHRE SPRGSGGAEA ALEEAARGPI LVDTGGPWAR EALLGALAGQ 
       110        120        130        140        150
GVAPGDVTLV VGTHGHSDHI GNLGLFPGAA LLVSHDFCLP GGRYLPHGLG 
       160        170        180        190        200
EGQPLRLGPG LEVWATPGHG GQRDVSVVVA GTALGTVVVA GDVFERDGDE 
       210        220        230        240        250
DSWQALSEDP AAQERSRKRV LVVADVVVPG HGPPFRVLRE ASQPETEGGG 
       260 
NSQQEPVVGD EEPALH

Length:266

Mass (Da):27,202

Last modified:April 3, 2007 - v1

Checksum:ⁱDFAA2E589D06B784

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JAV3	C9JAV3_HUMAN		Metallo-beta-lactamase domain-conta... Metallo-beta-lactamase domain-containing protein 1	MBLAC1	113	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	189	Missing in AAH31288 (PubMed:15489334).Curated		1
Sequence conflictⁱ	245	E → K in AAH31288 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_043567	79	P → H1 PublicationCorresponds to variant dbSNP:rs17852945Ensembl.		1
Natural variantⁱVAR_043568	114	H → N1 PublicationCorresponds to variant dbSNP:rs17852946Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH236956 Genomic DNA Translation: EAL23849.1 CH471091 Genomic DNA Translation: EAW76587.1 BC031288 mRNA Translation: AAH31288.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43620.1
NCBI Reference Sequences More...RefSeqⁱ	NP_981942.1, NM_203397.2 XP_005250307.1, XM_005250250.3

Genome annotation databases

Ensemblⁱ	ENST00000398075; ENSP00000381150; ENSG00000214309
GeneIDⁱ	255374
KEGGⁱ	hsa:255374
UCSC genome browser More...UCSCⁱ	uc003utp.4, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A4D2B0	Metallo-beta-lactamase domain-containing protein 1 (Fragment)		HUMAN		113	UniRef100_A4D2B0

Protein	Similar proteins		Species	Score	Length	Source
A4D2B0	Metallo-beta-lactamase domain-containing protein 1 (Fragment)		HUMAN		113	UniRef90_A4D2B0
Metallo-beta-lactamase domain-containing protein 1		MACMU		278
Metallo-beta-lactamase domain-containing protein 1		CEBIM		266
Metallo-beta-lactamase domain-containing protein 1		GORGO		266
Metallo-beta-lactamase domain-containing protein 1		AOTNA		266
+22

Protein	Similar proteins		Species	Score	Length	Source
A4D2B0	Metallo-beta-lactamase domain-containing protein 1		MOUSE		260	UniRef50_A4D2B0
Metallo-beta-lactamase domain-containing protein 1		RAT		251
Metallo-beta-lactamase domain-containing protein 1		BOVIN		263
Metallo-beta-lactamase domain-containing protein 1 (Fragment)		HUMAN		113
Metallo-beta-lactamase domain-containing protein 1		MACMU		278
+159

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH236956 Genomic DNA Translation: EAL23849.1 CH471091 Genomic DNA Translation: EAW76587.1 BC031288 mRNA Translation: AAH31288.1
CCDSⁱ	CCDS43620.1
RefSeqⁱ	NP_981942.1, NM_203397.2 XP_005250307.1, XM_005250250.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4V0H	X-ray	1.79	A/B/C/D	1-266	[»]
SMRⁱ	A4D2B0
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	129099, 15 interactors
IntActⁱ	A4D2B0, 3 interactors
STRINGⁱ	9606.ENSP00000381150

PTM databases

iPTMnetⁱ	A4D2B0
PhosphoSitePlusⁱ	A4D2B0

Genetic variation databases

BioMutaⁱ	MBLAC1

BioMutaⁱ

MBLAC1

Proteomic databases

EPDⁱ	A4D2B0
jPOSTⁱ	A4D2B0
MassIVEⁱ	A4D2B0
MaxQBⁱ	A4D2B0
PaxDbⁱ	A4D2B0
PeptideAtlasⁱ	A4D2B0
PRIDEⁱ	A4D2B0
ProteomicsDBⁱ	642

Protocols and materials databases

Antibodypediaⁱ	71061, 16 antibodies
The DNASU plasmid repository More...DNASUⁱ	255374

Genome annotation databases

Ensemblⁱ	ENST00000398075; ENSP00000381150; ENSG00000214309
GeneIDⁱ	255374
KEGGⁱ	hsa:255374
UCSCⁱ	uc003utp.4, human

Organism-specific databases

CTDⁱ	255374
DisGeNETⁱ	255374
GeneCardsⁱ	MBLAC1
HGNCⁱ	HGNC:22180, MBLAC1
HPAⁱ	ENSG00000214309, Low tissue specificity
neXtProtⁱ	NX_A4D2B0
PharmGKBⁱ	PA164722227
VEuPathDBⁱ	HostDB:ENSG00000214309
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4736, Eukaryota
GeneTreeⁱ	ENSGT00390000016193
HOGENOMⁱ	CLU_030571_2_6_1
InParanoidⁱ	A4D2B0
OMAⁱ	QVWATPG
OrthoDBⁱ	1139836at2759
PhylomeDBⁱ	A4D2B0
TreeFamⁱ	TF316508

Enzyme and pathway databases

PathwayCommonsⁱ	A4D2B0

PathwayCommonsⁱ

A4D2B0

Miscellaneous databases

BioGRID-ORCSⁱ	255374, 15 hits in 1009 CRISPR screens
GenomeRNAiⁱ	255374
Pharosⁱ	A4D2B0, Tdark
Protein Ontology More...PROⁱ	PR:A4D2B0
RNActⁱ	A4D2B0, protein

Gene expression databases

Bgeeⁱ	ENSG00000214309, Expressed in cerebellum and 153 other tissues
ExpressionAtlasⁱ	A4D2B0, baseline and differential
Genevisibleⁱ	A4D2B0, HS

Family and domain databases

Gene3Dⁱ	3.60.15.10, 1 hit
InterProⁱ	View protein in InterPro IPR039344, MBLAC1 IPR001279, Metallo-B-lactamas IPR036866, RibonucZ/Hydroxyglut_hydro
PANTHERⁱ	PTHR23200, PTHR23200, 1 hit
Pfamⁱ	View protein in Pfam PF00753, Lactamase_B, 1 hit
SMARTⁱ	View protein in SMART SM00849, Lactamase_B, 1 hit
SUPFAMⁱ	SSF56281, SSF56281, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MBLC1_HUMAN
Accessionⁱ	A4D2B0Primary (citable) accession number: A4D2B0 Secondary accession number(s): Q8N5X8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
	Last sequence update:	April 3, 2007
	Last modified:	September 29, 2021
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniRef

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UniProtKB - A4D2B0 (MBLC1_HUMAN)

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Metallo-beta-lactamase domain-containing protein 1

MBLAC1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoplasm and Cytosol

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ