UniProtKB - A4D2B0 (MBLC1_HUMAN)
Protein
Metallo-beta-lactamase domain-containing protein 1
Gene
MBLAC1
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 114 | Zinc 1By similarity | 1 | |
Metal bindingi | 116 | Zinc 1By similarity | 1 | |
Metal bindingi | 118 | Zinc 2By similarity | 1 | |
Metal bindingi | 119 | Zinc 2By similarity | 1 | |
Metal bindingi | 169 | Zinc 1By similarity | 1 | |
Metal bindingi | 231 | Zinc 2By similarity | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MBLAC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000214309.4 |
HGNCi | HGNC:22180 MBLAC1 |
neXtProti | NX_A4D2B0 |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA164722227 |
Polymorphism and mutation databases
BioMutai | MBLAC1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337027 | 1 – 266 | Metallo-beta-lactamase domain-containing protein 1Add BLAST | 266 |
Proteomic databases
EPDi | A4D2B0 |
jPOSTi | A4D2B0 |
MaxQBi | A4D2B0 |
PaxDbi | A4D2B0 |
PRIDEi | A4D2B0 |
ProteomicsDBi | 642 |
PTM databases
iPTMneti | A4D2B0 |
PhosphoSitePlusi | A4D2B0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000214309 Expressed in 135 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | A4D2B0 baseline and differential |
Genevisiblei | A4D2B0 HS |
Organism-specific databases
HPAi | HPA071574 |
Interactioni
Protein-protein interaction databases
BioGridi | 129099, 3 interactors |
STRINGi | 9606.ENSP00000381150 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V0H | X-ray | 1.79 | A/B/C/D | 1-266 | [»] | |
ProteinModelPortali | A4D2B0 | |||||
SMRi | A4D2B0 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4736 Eukaryota ENOG4111N4G LUCA |
GeneTreei | ENSGT00390000016193 |
HOGENOMi | HOG000022054 |
InParanoidi | A4D2B0 |
OMAi | QGYAEPE |
OrthoDBi | 1139836at2759 |
PhylomeDBi | A4D2B0 |
TreeFami | TF316508 |
Family and domain databases
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279 Metallo-B-lactamas IPR039344 Metallo-B-lactamas_prot IPR036866 RibonucZ/Hydroxyglut_hydro |
PANTHERi | PTHR23200 PTHR23200, 1 hit |
Pfami | View protein in Pfam PF00753 Lactamase_B, 1 hit |
SMARTi | View protein in SMART SM00849 Lactamase_B, 1 hit |
SUPFAMi | SSF56281 SSF56281, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A4D2B0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTEPLCGAS PLLVPGDPYS VVVLLQGYAE PEGVGDAVRA DGSVTLVLPQ
60 70 80 90 100
TRGPASSHRE SPRGSGGAEA ALEEAARGPI LVDTGGPWAR EALLGALAGQ
110 120 130 140 150
GVAPGDVTLV VGTHGHSDHI GNLGLFPGAA LLVSHDFCLP GGRYLPHGLG
160 170 180 190 200
EGQPLRLGPG LEVWATPGHG GQRDVSVVVA GTALGTVVVA GDVFERDGDE
210 220 230 240 250
DSWQALSEDP AAQERSRKRV LVVADVVVPG HGPPFRVLRE ASQPETEGGG
260
NSQQEPVVGD EEPALH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JAV3 | C9JAV3_HUMAN | Metallo-beta-lactamase domain-conta... | MBLAC1 | 113 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 189 | Missing in AAH31288 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 245 | E → K in AAH31288 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043567 | 79 | P → H1 PublicationCorresponds to variant dbSNP:rs17852945Ensembl. | 1 | |
Natural variantiVAR_043568 | 114 | H → N1 PublicationCorresponds to variant dbSNP:rs17852946Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH236956 Genomic DNA Translation: EAL23849.1 CH471091 Genomic DNA Translation: EAW76587.1 BC031288 mRNA Translation: AAH31288.1 |
CCDSi | CCDS43620.1 |
RefSeqi | NP_981942.1, NM_203397.2 XP_005250307.1, XM_005250250.3 |
UniGenei | Hs.632319 |
Genome annotation databases
Ensembli | ENST00000398075; ENSP00000381150; ENSG00000214309 |
GeneIDi | 255374 |
KEGGi | hsa:255374 |
UCSCi | uc003utp.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH236956 Genomic DNA Translation: EAL23849.1 CH471091 Genomic DNA Translation: EAW76587.1 BC031288 mRNA Translation: AAH31288.1 |
CCDSi | CCDS43620.1 |
RefSeqi | NP_981942.1, NM_203397.2 XP_005250307.1, XM_005250250.3 |
UniGenei | Hs.632319 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V0H | X-ray | 1.79 | A/B/C/D | 1-266 | [»] | |
ProteinModelPortali | A4D2B0 | |||||
SMRi | A4D2B0 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 129099, 3 interactors |
STRINGi | 9606.ENSP00000381150 |
PTM databases
iPTMneti | A4D2B0 |
PhosphoSitePlusi | A4D2B0 |
Polymorphism and mutation databases
BioMutai | MBLAC1 |
Proteomic databases
EPDi | A4D2B0 |
jPOSTi | A4D2B0 |
MaxQBi | A4D2B0 |
PaxDbi | A4D2B0 |
PRIDEi | A4D2B0 |
ProteomicsDBi | 642 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000398075; ENSP00000381150; ENSG00000214309 |
GeneIDi | 255374 |
KEGGi | hsa:255374 |
UCSCi | uc003utp.4 human |
Organism-specific databases
CTDi | 255374 |
EuPathDBi | HostDB:ENSG00000214309.4 |
GeneCardsi | MBLAC1 |
HGNCi | HGNC:22180 MBLAC1 |
HPAi | HPA071574 |
neXtProti | NX_A4D2B0 |
PharmGKBi | PA164722227 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4736 Eukaryota ENOG4111N4G LUCA |
GeneTreei | ENSGT00390000016193 |
HOGENOMi | HOG000022054 |
InParanoidi | A4D2B0 |
OMAi | QGYAEPE |
OrthoDBi | 1139836at2759 |
PhylomeDBi | A4D2B0 |
TreeFami | TF316508 |
Miscellaneous databases
GenomeRNAii | 255374 |
PROi | PR:A4D2B0 |
Gene expression databases
Bgeei | ENSG00000214309 Expressed in 135 organ(s), highest expression level in cerebellum |
ExpressionAtlasi | A4D2B0 baseline and differential |
Genevisiblei | A4D2B0 HS |
Family and domain databases
Gene3Di | 3.60.15.10, 1 hit |
InterProi | View protein in InterPro IPR001279 Metallo-B-lactamas IPR039344 Metallo-B-lactamas_prot IPR036866 RibonucZ/Hydroxyglut_hydro |
PANTHERi | PTHR23200 PTHR23200, 1 hit |
Pfami | View protein in Pfam PF00753 Lactamase_B, 1 hit |
SMARTi | View protein in SMART SM00849 Lactamase_B, 1 hit |
SUPFAMi | SSF56281 SSF56281, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | MBLC1_HUMAN | |
Accessioni | A4D2B0Primary (citable) accession number: A4D2B0 Secondary accession number(s): Q8N5X8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | April 3, 2007 | |
Last modified: | January 16, 2019 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations