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Protein

Protein LCHN

Gene

LCHN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LCHN
Gene namesi
Name:LCHN
Synonyms:KIAA1147
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000257093.6
HGNCiHGNC:29472 KIAA1147
neXtProtiNX_A4D1U4

Pathology & Biotechi

Organism-specific databases

DisGeNETi57189
OpenTargetsiENSG00000257093
PharmGKBiPA145148613

Polymorphism and mutation databases

BioMutaiLCHN

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003152212 – 455Protein LCHNAdd BLAST454

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvaline1 Publication1
Modified residuei41Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

EPDiA4D1U4
MaxQBiA4D1U4
PaxDbiA4D1U4
PRIDEiA4D1U4
ProteomicsDBi632

PTM databases

iPTMnetiA4D1U4
PhosphoSitePlusiA4D1U4

Expressioni

Gene expression databases

BgeeiENSG00000257093 Expressed in 181 organ(s), highest expression level in caput epididymis
CleanExiHS_KIAA1147
ExpressionAtlasiA4D1U4 baseline and differential
GenevisibleiA4D1U4 HS

Organism-specific databases

HPAiHPA029467
HPA061437

Interactioni

Protein-protein interaction databases

BioGridi121438, 8 interactors
STRINGi9606.ENSP00000445768

Structurei

3D structure databases

ProteinModelPortaliA4D1U4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 187uDENNPROSITE-ProRule annotationAdd BLAST170
Domaini214 – 362cDENNPROSITE-ProRule annotationAdd BLAST149
Domaini364 – 455dDENNPROSITE-ProRule annotationAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 39Poly-Gly10
Compositional biasi276 – 279Poly-Cys4

Sequence similaritiesi

Belongs to the LCHN family.Curated

Phylogenomic databases

eggNOGiKOG4704 Eukaryota
ENOG410XQBR LUCA
GeneTreeiENSGT00590000083189
HOGENOMiHOG000261648
HOVERGENiHBG108083
InParanoidiA4D1U4
OMAiNDQRQML
OrthoDBiEOG091G0CRD
PhylomeDBiA4D1U4
TreeFamiTF329174

Family and domain databases

InterProiView protein in InterPro
IPR018626 DUF2347
IPR037516 Tripartite_DENN
PfamiView protein in Pfam
PF09804 DUF2347, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A4D1U4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEQGDAAPL LRWAEGPAVS LPQAPQPQAG GWGRGGGGGA RPAAEPPRRR
60 70 80 90 100
EPEEPAAPEV LLQPGRLELG DVEEDQVVAV FVVTFDPRSG NMVEWCLPQD
110 120 130 140 150
IDLEGVEFKS MASGSHKIQS DFIYFRKGPF FGLACFANMP VESELERGAR
160 170 180 190 200
MKSVGILSPS YTLLYRYMHF LENQVRHQLE MPGHYSHLAA FYEDKKGVLH
210 220 230 240 250
AGPGRGSSLP PVYWLPSIHR YMYPEMKITH PAGCMSQFIK FFGEQILILW
260 270 280 290 300
KFALLRKRIL IFSPPPVGVV CYRVYCCCCL ANVSLPGIGG TIPESKPFFY
310 320 330 340 350
VNVADIESLE VEVSYVACTT EKIFEEKREL YDVYVDNQNV KTHHDHLQPL
360 370 380 390 400
LKINSADREK YRRLNEQRQM LLYSQEVEED YNPCEEDLFV LFFLEQNNRI
410 420 430 440 450
FQTLLEVSAS QDKTLTAEHA RGMGLDPQGD RSFLLDLLEA YGIDVMLVID

NPCCP
Length:455
Mass (Da):51,446
Last modified:April 3, 2007 - v1
Checksum:i43449F194B74D194
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J7X6C9J7X6_HUMAN
KIAA1147
KIAA1147
351Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA Translation: EAL24019.1
CH471070 Genomic DNA Translation: EAW83974.1
AB032973 mRNA Translation: BAA86461.2
CCDSiCCDS47726.1
RefSeqiNP_001073861.1, NM_001080392.1
UniGeneiHs.521240

Genome annotation databases

EnsembliENST00000536163; ENSP00000445768; ENSG00000257093
ENST00000575464; ENSP00000459381; ENSG00000262599
GeneIDi57189
KEGGihsa:57189
UCSCiuc003vwk.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH236950 Genomic DNA Translation: EAL24019.1
CH471070 Genomic DNA Translation: EAW83974.1
AB032973 mRNA Translation: BAA86461.2
CCDSiCCDS47726.1
RefSeqiNP_001073861.1, NM_001080392.1
UniGeneiHs.521240

3D structure databases

ProteinModelPortaliA4D1U4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121438, 8 interactors
STRINGi9606.ENSP00000445768

PTM databases

iPTMnetiA4D1U4
PhosphoSitePlusiA4D1U4

Polymorphism and mutation databases

BioMutaiLCHN

Proteomic databases

EPDiA4D1U4
MaxQBiA4D1U4
PaxDbiA4D1U4
PRIDEiA4D1U4
ProteomicsDBi632

Protocols and materials databases

DNASUi57189
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000536163; ENSP00000445768; ENSG00000257093
ENST00000575464; ENSP00000459381; ENSG00000262599
GeneIDi57189
KEGGihsa:57189
UCSCiuc003vwk.3 human

Organism-specific databases

CTDi57189
DisGeNETi57189
EuPathDBiHostDB:ENSG00000257093.6
GeneCardsiKIAA1147
H-InvDBiHIX0007153
HGNCiHGNC:29472 KIAA1147
HPAiHPA029467
HPA061437
neXtProtiNX_A4D1U4
OpenTargetsiENSG00000257093
PharmGKBiPA145148613
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4704 Eukaryota
ENOG410XQBR LUCA
GeneTreeiENSGT00590000083189
HOGENOMiHOG000261648
HOVERGENiHBG108083
InParanoidiA4D1U4
OMAiNDQRQML
OrthoDBiEOG091G0CRD
PhylomeDBiA4D1U4
TreeFamiTF329174

Miscellaneous databases

ChiTaRSiKIAA1147 human
GenomeRNAii57189
PROiPR:A4D1U4

Gene expression databases

BgeeiENSG00000257093 Expressed in 181 organ(s), highest expression level in caput epididymis
CleanExiHS_KIAA1147
ExpressionAtlasiA4D1U4 baseline and differential
GenevisibleiA4D1U4 HS

Family and domain databases

InterProiView protein in InterPro
IPR018626 DUF2347
IPR037516 Tripartite_DENN
PfamiView protein in Pfam
PF09804 DUF2347, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLCHN_HUMAN
AccessioniPrimary (citable) accession number: A4D1U4
Secondary accession number(s): Q9ULS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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