UniProtKB - A4D1Q0 (A4D1Q0_HUMAN)
Protein
Muscarinic acetylcholine receptor
Gene
CHRM2
Organism
Homo sapiens (Human)
Status
Functioni
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- G protein-coupled acetylcholine receptor activity Source: UniProtKB-UniRule
GO - Biological processi
- regulation of heart contraction Source: InterPro
- regulation of smooth muscle contraction Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Muscarinic acetylcholine receptorUniRule annotation |
Gene namesi | Name:CHRM2Imported ORF Names:hCG_1641225Imported, tcag7.414Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000181072.11 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
Other locations
- asymmetric synapse Source: Ensembl
- axon terminus Source: Ensembl
- dendrite Source: Ensembl
- glutamatergic synapse Source: Ensembl
- neuronal cell body Source: Ensembl
- symmetric synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 23 – 48 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 60 – 86 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 98 – 119 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 140 – 165 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 185 – 209 | HelicalUniRule annotationAdd BLAST | 25 | |
Transmembranei | 385 – 403 | HelicalUniRule annotationAdd BLAST | 19 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotation, SynapseExpressioni
Gene expression databases
Bgeei | ENSG00000181072, Expressed in heart and 82 other tissues |
ExpressionAtlasi | A4D1Q0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 440 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 401 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 218 – 355 | DisorderedSequence analysisAdd BLAST | 138 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 230 – 256 | PolarSequence analysisAdd BLAST | 27 | |
Compositional biasi | 280 – 297 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 305 – 355 | PolarSequence analysisAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_009579_11_2_1 |
OMAi | NSKLTCI |
OrthoDBi | 1245472at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001065, Musac_Ach_M2_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00539, MUSCRINICM2R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A4D1Q0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV
60 70 80 90 100
NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL
110 120 130 140 150
ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL
160 170 180 190 200
SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI
210 220 230 240 250
IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS
260 270 280 290 300
SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
310 320 330 340 350
ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS
360 370 380 390 400
GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW
410 420 430 440 450
APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT
460
FKHLLMCHYK NIGATR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290236 mRNA Translation: BAF82925.1 CH236950 Genomic DNA Translation: EAL24054.1 CH471070 Genomic DNA Translation: EAW83866.1 |
RefSeqi | NP_000730.1, NM_000739.2 NP_001006627.1, NM_001006626.1 NP_001006628.1, NM_001006627.1 NP_001006629.1, NM_001006628.1 NP_001006630.1, NM_001006629.1 NP_001006631.1, NM_001006630.1 NP_001006632.1, NM_001006631.1 NP_001006633.1, NM_001006632.1 XP_011514071.1, XM_011515769.2 |
Genome annotation databases
GeneIDi | 1129 |
KEGGi | hsa:1129 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK290236 mRNA Translation: BAF82925.1 CH236950 Genomic DNA Translation: EAL24054.1 CH471070 Genomic DNA Translation: EAW83866.1 |
RefSeqi | NP_000730.1, NM_000739.2 NP_001006627.1, NM_001006626.1 NP_001006628.1, NM_001006627.1 NP_001006629.1, NM_001006628.1 NP_001006630.1, NM_001006629.1 NP_001006631.1, NM_001006630.1 NP_001006632.1, NM_001006631.1 NP_001006633.1, NM_001006632.1 XP_011514071.1, XM_011515769.2 |
3D structure databases
SMRi | A4D1Q0 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A4D1Q0 |
Protein family/group databases
GPCRDBi | Search... |
Protocols and materials databases
Antibodypediai | 18171, 547 antibodies |
DNASUi | 1129 |
Genome annotation databases
GeneIDi | 1129 |
KEGGi | hsa:1129 |
Organism-specific databases
CTDi | 1129 |
EuPathDBi | HostDB:ENSG00000181072.11 |
PharmGKBi | PA111 |
Phylogenomic databases
HOGENOMi | CLU_009579_11_2_1 |
OMAi | NSKLTCI |
OrthoDBi | 1245472at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1129, 4 hits in 839 CRISPR screens |
ChiTaRSi | CHRM2, human |
GenomeRNAii | 1129 |
Gene expression databases
Bgeei | ENSG00000181072, Expressed in heart and 82 other tissues |
ExpressionAtlasi | A4D1Q0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001065, Musac_Ach_M2_rcpt IPR000995, Musac_Ach_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00243, MUSCARINICR PR00539, MUSCRINICM2R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4D1Q0_HUMAN | |
Accessioni | A4D1Q0Primary (citable) accession number: A4D1Q0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |