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Protein

WD repeat-containing protein 91

Gene

WDR91

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May play a role in meiosis (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol 3-kinase regulator activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
A4D1P6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 91Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR91Imported
ORF Names:HSPC049Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000105875.13

Human Gene Nomenclature Database

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HGNCi
HGNC:24997 WDR91

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A4D1P6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000105875

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162409166

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR91

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957461 – 747WD repeat-containing protein 91Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei256PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A4D1P6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A4D1P6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A4D1P6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4D1P6

PRoteomics IDEntifications database

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PRIDEi
A4D1P6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
624
625 [A4D1P6-2]
626 [A4D1P6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A4D1P6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A4D1P6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105875 Expressed in 193 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_WDR91

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A4D1P6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4D1P6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024260

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WDR81; involved in early to late endosome cargo transport (PubMed:26783301, PubMed:27126989). Interacts with BECN1; negatively regulates the PI3 kinase/PI3K activity associated with endosomal membranes (PubMed:26783301).2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118837, 21 interactors

Protein interaction database and analysis system

More...
IntActi
A4D1P6, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346466

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A4D1P6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati406 – 445WD 1Add BLAST40
Repeati448 – 488WD 2Add BLAST41
Repeati515 – 555WD 3Add BLAST41
Repeati560 – 599WD 4Add BLAST40
Repeati602 – 641WD 5Add BLAST40
Repeati664 – 702WD 6Add BLAST39
Repeati709 – 747WD 7Add BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili183 – 215Sequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat WDR91 family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1333 Eukaryota
ENOG410XQIX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001566

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057115

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4D1P6

Identification of Orthologs from Complete Genome Data

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OMAi
NLCEISI

Database of Orthologous Groups

More...
OrthoDBi
321271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4D1P6

TreeFam database of animal gene trees

More...
TreeFami
TF317339

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR039724 WDR91

The PANTHER Classification System

More...
PANTHERi
PTHR13083 PTHR13083, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A4D1P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ
60 70 80 90 100
QLMQVYDLAA LRDYWSYLER RLFSRLEDIY RPTIHKLKTS LFRFYLVYTI
110 120 130 140 150
QTNRNDKAQE FFAKQATELQ NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ
160 170 180 190 200
WADTFIVSLH NFLSVLFQCM PVPVILNFDA ECQRTNQVQE ENEVLRQKLF
210 220 230 240 250
ALQAEIHRLK KEEQQPEEEE ALVQHKLPPY VSNMDRLGDS ELAMVCSQRN
260 270 280 290 300
ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQPQSSAK KESFGGQGTK
310 320 330 340 350
GKDPTSGAKD GKSLLSGLAT GESGWSQHRQ RRLQDHGKER KELFSTTTSQ
360 370 380 390 400
CAEKKPEASG PEAEPCPELH TEPVEPLTRA SSAGPEGGGV RPEQPFIVLG
410 420 430 440 450
QEEYGEHHSS IMHCRVDCSG RRVASLDVDG VIKVWSFNPI MQTKASSISK
460 470 480 490 500
SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT EAKKNLCEIN INDNMPRILS
510 520 530 540 550
LACSPNGASF VCSAAAPSLT SQVDFSAPDI GSKGMNQVPG RLLLWDTKTM
560 570 580 590 600
KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHECAMSW
610 620 630 640 650
RAHYGEVYSV EFSYDENTVY SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT
660 670 680 690 700
GPFVLSGYSG YKQVQVPRGR LFAFDSEGNY MLTCSATGGV IYKLGGDEKV
710 720 730 740
LESCLSLGGH RAPVVTVDWS TAMDCGTCLT ASMDGKIKLT TLLAHKA
Length:747
Mass (Da):83,344
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA93CF7F02D12629A
GO
Isoform 2 (identifier: A4D1P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     590-636: DMQQHECAMS...KFIQWNIHKS → VHPVEHPQEW...SSPQGPTLRF
     637-747: Missing.

Note: No experimental confirmation available.
Show »
Length:636
Mass (Da):71,352
Checksum:iBF7826528F2047B5
GO
Isoform 3 (identifier: A4D1P6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-365: CAEKKPEASGPEAEP → VWGCPEHPWGHSCSY
     366-747: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):42,112
Checksum:i8E984767FD792012
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1X0C9J1X0_HUMAN
WD repeat-containing protein 91
WDR91
712Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29021 differs from that shown. Reason: Frameshift at positions 136, 161, 166, 381, 392, 400, 405, 424, 442, 448, 458, 462, 501, 505, 508, 605, 626, 646, 712 and 736.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti302K → R in BAA91785 (PubMed:14702039).Curated1
Sequence conflicti449S → F in AAF29021 (PubMed:11042152).Curated1
Sequence conflicti510F → L in AAF29021 (PubMed:11042152).Curated1
Sequence conflicti706S → K in AAF29021 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033358257P → L6 PublicationsCorresponds to variant dbSNP:rs292592Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027058351 – 365CAEKK…PEAEP → VWGCPEHPWGHSCSY in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_027059366 – 747Missing in isoform 3. 1 PublicationAdd BLAST382
Alternative sequenceiVSP_027060590 – 636DMQQH…NIHKS → VHPVEHPQEWPQGIRVQPPL RCHGPLCAVWIQRLQAGSSP QGPTLRF in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_027061637 – 747Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF161534 mRNA Translation: AAF29021.1 Frameshift.
AK001606 mRNA Translation: BAA91785.1
AK022935 mRNA Translation: BAB14316.1
BX640957 mRNA Translation: CAE45977.1
AC009542 Genomic DNA No translation available.
AC083862 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24062.1
BC009939 mRNA Translation: AAH09939.2
BC017246 mRNA Translation: AAH17246.1
BC063394 mRNA Translation: AAH63394.1
AL136940 mRNA Translation: CAB66874.2
CR533561 mRNA Translation: CAG38592.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34758.1 [A4D1P6-1]

NCBI Reference Sequences

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RefSeqi
NP_054868.3, NM_014149.3 [A4D1P6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.459858

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354475; ENSP00000346466; ENSG00000105875 [A4D1P6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
29062

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:29062

UCSC genome browser

More...
UCSCi
uc003vsp.3 human [A4D1P6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161534 mRNA Translation: AAF29021.1 Frameshift.
AK001606 mRNA Translation: BAA91785.1
AK022935 mRNA Translation: BAB14316.1
BX640957 mRNA Translation: CAE45977.1
AC009542 Genomic DNA No translation available.
AC083862 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24062.1
BC009939 mRNA Translation: AAH09939.2
BC017246 mRNA Translation: AAH17246.1
BC063394 mRNA Translation: AAH63394.1
AL136940 mRNA Translation: CAB66874.2
CR533561 mRNA Translation: CAG38592.1
CCDSiCCDS34758.1 [A4D1P6-1]
RefSeqiNP_054868.3, NM_014149.3 [A4D1P6-1]
UniGeneiHs.459858

3D structure databases

ProteinModelPortaliA4D1P6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118837, 21 interactors
IntActiA4D1P6, 8 interactors
STRINGi9606.ENSP00000346466

PTM databases

iPTMnetiA4D1P6
PhosphoSitePlusiA4D1P6

Polymorphism and mutation databases

BioMutaiWDR91

Proteomic databases

EPDiA4D1P6
jPOSTiA4D1P6
MaxQBiA4D1P6
PaxDbiA4D1P6
PRIDEiA4D1P6
ProteomicsDBi624
625 [A4D1P6-2]
626 [A4D1P6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
29062
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354475; ENSP00000346466; ENSG00000105875 [A4D1P6-1]
GeneIDi29062
KEGGihsa:29062
UCSCiuc003vsp.3 human [A4D1P6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29062
EuPathDBiHostDB:ENSG00000105875.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR91

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0167835
HGNCiHGNC:24997 WDR91
HPAiHPA024260
neXtProtiNX_A4D1P6
OpenTargetsiENSG00000105875
PharmGKBiPA162409166

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1333 Eukaryota
ENOG410XQIX LUCA
GeneTreeiENSGT00390000001566
HOVERGENiHBG057115
InParanoidiA4D1P6
OMAiNLCEISI
OrthoDBi321271at2759
PhylomeDBiA4D1P6
TreeFamiTF317339

Enzyme and pathway databases

SignaLinkiA4D1P6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR91 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29062

Protein Ontology

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PROi
PR:A4D1P6

Gene expression databases

BgeeiENSG00000105875 Expressed in 193 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_WDR91
ExpressionAtlasiA4D1P6 baseline and differential
GenevisibleiA4D1P6 HS

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR039724 WDR91
PANTHERiPTHR13083 PTHR13083, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR91_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4D1P6
Secondary accession number(s): A6NK54
, C9JMI4, Q6FI65, Q6MZQ1, Q6P4I1, Q96AE5, Q96G63, Q9H062, Q9H9B6, Q9NVG7, Q9NZY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 30, 2010
Last modified: January 16, 2019
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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