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Entry version 106 (08 May 2019)
Sequence version 1 (03 Apr 2007)
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Protein

GTP-binding protein 10

Gene

GTPBP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi155 – 162GTPPROSITE-ProRule annotation8
Nucleotide bindingi202 – 206GTPPROSITE-ProRule annotation5
Nucleotide bindingi278 – 281GTPPROSITE-ProRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GTP-binding protein 10
Alternative name(s):
Protein obg homolog 2
Short name:
ObgH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTPBP10
Synonyms:OBGH2
ORF Names:UG0751c10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25106 GTPBP10

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610920 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A4D1E9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
85865

Open Targets

More...
OpenTargetsi
ENSG00000105793

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162390482

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GTPBP10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003126301 – 387GTP-binding protein 10Add BLAST387

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A4D1E9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A4D1E9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A4D1E9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4D1E9

PRoteomics IDEntifications database

More...
PRIDEi
A4D1E9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
615
616 [A4D1E9-2]
617 [A4D1E9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A4D1E9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A4D1E9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105793 Expressed in 195 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A4D1E9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4D1E9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA021076

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124573, 25 interactors

Protein interaction database and analysis system

More...
IntActi
A4D1E9, 12 interactors

Molecular INTeraction database

More...
MINTi
A4D1E9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000222511

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A4D1E9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 148ObgPROSITE-ProRule annotationAdd BLAST136
Domaini149 – 344OBG-type GPROSITE-ProRule annotationAdd BLAST196

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1489 Eukaryota
COG0536 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155589

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4D1E9

Identification of Orthologs from Complete Genome Data

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OMAi
TPQIASY

Database of Orthologous Groups

More...
OrthoDBi
1150635at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4D1E9

TreeFam database of animal gene trees

More...
TreeFami
TF314774

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01898 Obg, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.70.210.12, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031167 G_OBG
IPR035101 GTP-bd_Obg
IPR006169 GTP1_OBG_dom
IPR036726 GTP1_OBG_dom_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01018 GTP1_OBG, 1 hit
PF01926 MMR_HSR1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002401 GTP_bd_Obg/CgtA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00326 GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF82051 SSF82051, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51710 G_OBG, 1 hit
PS51883 OBG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A4D1E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVHCSCVLFR KYGNFIDKLR LFTRGGSGGM GYPRLGGEGG KGGDVWVVAQ
60 70 80 90 100
NRMTLKQLKD RYPRKRFVAG VGANSKISAL KGSKGKDCEI PVPVGISVTD
110 120 130 140 150
ENGKIIGELN KENDRILVAQ GGLGGKLLTN FLPLKGQKRI IHLDLKLIAD
160 170 180 190 200
VGLVGFPNAG KSSLLSCVSH AKPAIADYAF TTLKPELGKI MYSDFKQISV
210 220 230 240 250
ADLPGLIEGA HMNKGMGHKF LKHIERTRQL LFVVDISGFQ LSSHTQYRTA
260 270 280 290 300
FETIILLTKE LELYKEELQT KPALLAVNKM DLPDAQDKFH ELMSQLQNPK
310 320 330 340 350
DFLHLFEKNM IPERTVEFQH IIPISAVTGE GIEELKNCIR KSLDEQANQE
360 370 380
NDALHKKQLL NLWISDTMSS TEPPSKHAVT TSKMDII
Length:387
Mass (Da):42,933
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A89697B83320075
GO
Isoform 2 (identifier: A4D1E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-155: Missing.

Show »
Length:308
Mass (Da):34,651
Checksum:i2496B9D34CCA3FCB
GO
Isoform 3 (identifier: A4D1E9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-116: GELNKENDRI → DSQMLENPLC
     117-387: Missing.

Show »
Length:116
Mass (Da):12,577
Checksum:iC4DEFBC7A945703E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8R7C9J8R7_HUMAN
GTP-binding protein 10
GTPBP10
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNI1C9JNI1_HUMAN
GTP-binding protein 10
GTPBP10
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEQ8C9JEQ8_HUMAN
GTP-binding protein 10
GTPBP10
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBY0F8WBY0_HUMAN
GTP-binding protein 10
GTPBP10
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCN4F8WCN4_HUMAN
GTP-binding protein 10
GTPBP10
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBB5F8WBB5_HUMAN
GTP-binding protein 10
GTPBP10
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64R → G in AAI07715 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03754388C → W3 PublicationsCorresponds to variant dbSNP:rs42663Ensembl.1
Natural variantiVAR_037544110N → S1 PublicationCorresponds to variant dbSNP:rs42664Ensembl.1
Natural variantiVAR_037545164L → F. Corresponds to variant dbSNP:rs35001814Ensembl.1
Natural variantiVAR_037546368M → I1 PublicationCorresponds to variant dbSNP:rs17863999Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02988077 – 155Missing in isoform 2. 2 PublicationsAdd BLAST79
Alternative sequenceiVSP_029881107 – 116GELNKENDRI → DSQMLENPLC in isoform 3. 1 Publication10
Alternative sequenceiVSP_029882117 – 387Missing in isoform 3. 1 PublicationAdd BLAST271

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF351613 mRNA Translation: AAN76513.1
AK095561 mRNA Translation: BAC04573.1
AK294325 mRNA Translation: BAG57597.1
CR933597 mRNA Translation: CAI45922.1
AC002064 Genomic DNA No translation available.
AC006153 Genomic DNA Translation: AAD15550.2
CH236949 Genomic DNA Translation: EAL24164.1
CH471091 Genomic DNA Translation: EAW76880.1
CH471091 Genomic DNA Translation: EAW76882.1
BC004923 mRNA Translation: AAH04923.3
BC021573 mRNA Translation: AAH21573.2
BC107714 mRNA Translation: AAI07715.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43614.1 [A4D1E9-2]
CCDS5617.1 [A4D1E9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001036182.1, NM_001042717.2 [A4D1E9-2]
NP_149098.2, NM_033107.3 [A4D1E9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222511; ENSP00000222511; ENSG00000105793 [A4D1E9-1]
ENST00000257659; ENSP00000257659; ENSG00000105793 [A4D1E9-2]
ENST00000380058; ENSP00000369398; ENSG00000105793 [A4D1E9-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
85865

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85865

UCSC genome browser

More...
UCSCi
uc003ukm.3 human [A4D1E9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF351613 mRNA Translation: AAN76513.1
AK095561 mRNA Translation: BAC04573.1
AK294325 mRNA Translation: BAG57597.1
CR933597 mRNA Translation: CAI45922.1
AC002064 Genomic DNA No translation available.
AC006153 Genomic DNA Translation: AAD15550.2
CH236949 Genomic DNA Translation: EAL24164.1
CH471091 Genomic DNA Translation: EAW76880.1
CH471091 Genomic DNA Translation: EAW76882.1
BC004923 mRNA Translation: AAH04923.3
BC021573 mRNA Translation: AAH21573.2
BC107714 mRNA Translation: AAI07715.1
CCDSiCCDS43614.1 [A4D1E9-2]
CCDS5617.1 [A4D1E9-1]
RefSeqiNP_001036182.1, NM_001042717.2 [A4D1E9-2]
NP_149098.2, NM_033107.3 [A4D1E9-1]

3D structure databases

SMRiA4D1E9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124573, 25 interactors
IntActiA4D1E9, 12 interactors
MINTiA4D1E9
STRINGi9606.ENSP00000222511

PTM databases

iPTMnetiA4D1E9
PhosphoSitePlusiA4D1E9

Polymorphism and mutation databases

BioMutaiGTPBP10

Proteomic databases

EPDiA4D1E9
jPOSTiA4D1E9
MaxQBiA4D1E9
PaxDbiA4D1E9
PRIDEiA4D1E9
ProteomicsDBi615
616 [A4D1E9-2]
617 [A4D1E9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222511; ENSP00000222511; ENSG00000105793 [A4D1E9-1]
ENST00000257659; ENSP00000257659; ENSG00000105793 [A4D1E9-2]
ENST00000380058; ENSP00000369398; ENSG00000105793 [A4D1E9-3]
GeneIDi85865
KEGGihsa:85865
UCSCiuc003ukm.3 human [A4D1E9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85865
DisGeNETi85865

GeneCards: human genes, protein and diseases

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GeneCardsi
GTPBP10
HGNCiHGNC:25106 GTPBP10
HPAiHPA021076
MIMi610920 gene
neXtProtiNX_A4D1E9
OpenTargetsiENSG00000105793
PharmGKBiPA162390482

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1489 Eukaryota
COG0536 LUCA
GeneTreeiENSGT00940000155589
InParanoidiA4D1E9
OMAiTPQIASY
OrthoDBi1150635at2759
PhylomeDBiA4D1E9
TreeFamiTF314774

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
85865

Protein Ontology

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PROi
PR:A4D1E9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000105793 Expressed in 195 organ(s), highest expression level in intestine
ExpressionAtlasiA4D1E9 baseline and differential
GenevisibleiA4D1E9 HS

Family and domain databases

CDDicd01898 Obg, 1 hit
Gene3Di2.70.210.12, 1 hit
InterProiView protein in InterPro
IPR031167 G_OBG
IPR035101 GTP-bd_Obg
IPR006169 GTP1_OBG_dom
IPR036726 GTP1_OBG_dom_sf
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01018 GTP1_OBG, 1 hit
PF01926 MMR_HSR1, 1 hit
PIRSFiPIRSF002401 GTP_bd_Obg/CgtA, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF82051 SSF82051, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS51883 OBG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGTPBA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4D1E9
Secondary accession number(s): B4DFY6
, Q3B7A6, Q5H9V2, Q8IXG8, Q8N982, Q8WU16, Q9BSP1, Q9Y6T6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 3, 2007
Last modified: May 8, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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