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Protein

Gamma-secretase-activating protein

Gene

GSAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.1 Publication

Miscellaneous

The gamma-secretase regulator activity is specifically inhibited by imatinib (also known as STI571 or Gleevec), an anticancer drug that selectively decreases amyloid-beta protein production. Imatinib binds PION/GSAP and acts by preventing PION/GSAP interaction with the gamma-secretase substrate, CTF-alpha (PubMed:20811458).1 Publication
Its role as an activator of amyloid-beta protein production makes it a promising therapeutic target for the treatment of Alzheimer disease.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • amyloid-beta binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-secretase-activating protein
Short name:
GSAP
Alternative name(s):
Protein pigeon homolog
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSAP
Synonyms:PION
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000186088.15

Human Gene Nomenclature Database

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HGNCi
HGNC:28042 GSAP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613552 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_A4D1B5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54103

Open Targets

More...
OpenTargetsi
ENSG00000186088

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164724500

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3638343

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GSAP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003358091 – 854Gamma-secretase-activating proteinAdd BLAST854
ChainiPRO_0000403728734 – 854Gamma-secretase-activating protein 16 kDa C-terminal formSequence analysisAdd BLAST121

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form.1 Publication

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A4D1B5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A4D1B5

MaxQB - The MaxQuant DataBase

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MaxQBi
A4D1B5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4D1B5

PRoteomics IDEntifications database

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PRIDEi
A4D1B5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
609
610 [A4D1B5-2]
611 [A4D1B5-3]
612 [A4D1B5-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
A4D1B5-1 [A4D1B5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A4D1B5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A4D1B5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186088 Expressed in 210 organ(s), highest expression level in small intestine Peyer's patch

CleanEx database of gene expression profiles

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CleanExi
HS_PION

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A4D1B5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A4D1B5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023994

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPP050673EBI-15875313,EBI-77613

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119901, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-59240N

Protein interaction database and analysis system

More...
IntActi
A4D1B5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000257626

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
A4D1B5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A4D1B5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GSAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG5Q Eukaryota
ENOG41129DZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012875

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095500

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A4D1B5

Identification of Orthologs from Complete Genome Data

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OMAi
ENISACH

Database of Orthologous Groups

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OrthoDBi
1035231at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4D1B5

TreeFam database of animal gene trees

More...
TreeFami
TF323853

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028010 GSAP_C_dom
IPR026172 GSAP_fam

The PANTHER Classification System

More...
PANTHERi
PTHR13630 PTHR13630, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14959 GSAP-16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A4D1B5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALRLVADFD LGKDVLPWLR AQRAVSEASG AGSGGADVLE NDYESLHVLN
60 70 80 90 100
VERNGNIIYT YKDDKGNVVF GLYDCQTRQN ELLYTFEKDL QVFSCSVNSE
110 120 130 140 150
RTLLAASLVQ STKEGKRNEL QPGSKCLTLL VEIHPVNNVK VLKAVDSYIW
160 170 180 190 200
VQFLYPHIES HPLPENHLLL ISEEKYIEQF RIHVAQEDGN RVVIKNSGHL
210 220 230 240 250
PRDRIAEDFV WAQWDMSEQR LYYIDLKKSR SILKCIQFYA DESYNLMFEV
260 270 280 290 300
PLDISLSNSG FKLVNFGCDY HQYRDKFSKH LTLCVFTNHT GSLCVCYSPK
310 320 330 340 350
CASWGQITYS VFYIHKGHSK TFTTSLENVG SHMTKGITFL NLDYYVAVYL
360 370 380 390 400
PGHFFHLLNV QHPDLICHNL FLTGNNEMID MLPHCPLQSL SGSLVLDCCS
410 420 430 440 450
GKLYRALLSQ SSLLQLLQNT CLDCEKMAAL HCALYCGQGA QFLEAQIIQW
460 470 480 490 500
ISENVSACHS FDLIQEFIIA SSYWSVYSET SNMDKLLPHS SVLTWNTEIP
510 520 530 540 550
GITLVTEDIA LPLMKVLSFK GYWEKLNSNL EYVKYAKPHF HYNNSVVRRE
560 570 580 590 600
WHNLISEEKT GKRRSAAYVR NILDNAVKVI SNLEARNLGP RLTPLLQEED
610 620 630 640 650
SHQRLLMGLM VSELKDHFLR HLQGVEKKKI EQMVLDYISK LLDLICHIVE
660 670 680 690 700
TNWRKHNLHS WVLHFNSRGS AAEFAVFHIM TRILEATNSL FLPLPPGFHT
710 720 730 740 750
LHTILGVQCL PLHNLLHCID SGVLLLTETA VIRLMKDLDN TEKNEKLKFS
760 770 780 790 800
IIVRLPPLIG QKICRLWDHP MSSNIISRNH VTRLLQNYKK QPRNSMINKS
810 820 830 840 850
SFSVEFLPLN YFIEILTDIE SSNQALYPFE GHDNVDAEFV EEAALKHTAM

LLGL
Length:854
Mass (Da):97,802
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7B4A3A95E2E8C3B
GO
Isoform 2 (identifier: A4D1B5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-446: Q → QWRQRADLNTNRVLSDFLK
     559-559: K → V
     560-854: Missing.

Show »
Length:577
Mass (Da):66,133
Checksum:i20F5F61CB33A4927
GO
Isoform 3 (identifier: A4D1B5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     559-559: K → V
     560-854: Missing.

Show »
Length:559
Mass (Da):63,918
Checksum:i76E5CF3E65566679
GO
Isoform 4 (identifier: A4D1B5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-606: Missing.

Show »
Length:248
Mass (Da):28,563
Checksum:i64786DCDA574C8D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZL33B7ZL33_HUMAN
Gamma-secretase-activating protein
GSAP PION
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0Q7H7C0Q7_HUMAN
Gamma-secretase-activating protein
GSAP
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRG7C9JRG7_HUMAN
Gamma-secretase-activating protein
GSAP
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD39023 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04346747H → R1 PublicationCorresponds to variant dbSNP:rs6949654Ensembl.1
Natural variantiVAR_043468305G → E. Corresponds to variant dbSNP:rs1527263Ensembl.1
Natural variantiVAR_043469649V → I. Corresponds to variant dbSNP:rs17151692Ensembl.1
Natural variantiVAR_043470653W → L. Corresponds to variant dbSNP:rs17151689Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0337711 – 606Missing in isoform 4. 1 PublicationAdd BLAST606
Alternative sequenceiVSP_033772446Q → QWRQRADLNTNRVLSDFLK in isoform 2. Curated1
Alternative sequenceiVSP_033773559K → V in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_033774560 – 854Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST295

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004921 Genomic DNA No translation available.
AC073635 Genomic DNA No translation available.
CH236949 Genomic DNA Translation: EAL24199.1
CH236949 Genomic DNA Translation: EAL24200.1
CH471091 Genomic DNA Translation: EAW77039.1
BC101499 mRNA Translation: AAI01500.2
AL834358 mRNA Translation: CAD39023.2 Different initiation.
AL079277 mRNA Translation: CAB45152.1
AL079297 mRNA Translation: CAB45193.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34672.2 [A4D1B5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_059135.2, NM_017439.3 [A4D1B5-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.186649

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000257626; ENSP00000257626; ENSG00000186088 [A4D1B5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54103

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54103

UCSC genome browser

More...
UCSCi
uc003ugf.3 human [A4D1B5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004921 Genomic DNA No translation available.
AC073635 Genomic DNA No translation available.
CH236949 Genomic DNA Translation: EAL24199.1
CH236949 Genomic DNA Translation: EAL24200.1
CH471091 Genomic DNA Translation: EAW77039.1
BC101499 mRNA Translation: AAI01500.2
AL834358 mRNA Translation: CAD39023.2 Different initiation.
AL079277 mRNA Translation: CAB45152.1
AL079297 mRNA Translation: CAB45193.1
CCDSiCCDS34672.2 [A4D1B5-1]
RefSeqiNP_059135.2, NM_017439.3 [A4D1B5-1]
UniGeneiHs.186649

3D structure databases

ProteinModelPortaliA4D1B5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119901, 4 interactors
DIPiDIP-59240N
IntActiA4D1B5, 1 interactor
STRINGi9606.ENSP00000257626

Chemistry databases

BindingDBiA4D1B5
ChEMBLiCHEMBL3638343

PTM databases

iPTMnetiA4D1B5
PhosphoSitePlusiA4D1B5

Polymorphism and mutation databases

BioMutaiGSAP

Proteomic databases

EPDiA4D1B5
jPOSTiA4D1B5
MaxQBiA4D1B5
PaxDbiA4D1B5
PRIDEiA4D1B5
ProteomicsDBi609
610 [A4D1B5-2]
611 [A4D1B5-3]
612 [A4D1B5-4]
TopDownProteomicsiA4D1B5-1 [A4D1B5-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257626; ENSP00000257626; ENSG00000186088 [A4D1B5-1]
GeneIDi54103
KEGGihsa:54103
UCSCiuc003ugf.3 human [A4D1B5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54103
DisGeNETi54103
EuPathDBiHostDB:ENSG00000186088.15

GeneCards: human genes, protein and diseases

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GeneCardsi
GSAP

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0006796
HGNCiHGNC:28042 GSAP
HPAiHPA023994
MIMi613552 gene
neXtProtiNX_A4D1B5
OpenTargetsiENSG00000186088
PharmGKBiPA164724500

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG5Q Eukaryota
ENOG41129DZ LUCA
GeneTreeiENSGT00390000012875
HOVERGENiHBG095500
InParanoidiA4D1B5
OMAiENISACH
OrthoDBi1035231at2759
PhylomeDBiA4D1B5
TreeFamiTF323853

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GSAP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Protein_pigeon_homolog

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54103

Protein Ontology

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PROi
PR:A4D1B5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186088 Expressed in 210 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_PION
ExpressionAtlasiA4D1B5 baseline and differential
GenevisibleiA4D1B5 HS

Family and domain databases

InterProiView protein in InterPro
IPR028010 GSAP_C_dom
IPR026172 GSAP_fam
PANTHERiPTHR13630 PTHR13630, 1 hit
PfamiView protein in Pfam
PF14959 GSAP-16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4D1B5
Secondary accession number(s): A4D1B6
, Q3MJC0, Q8ND73, Q9UMH3, Q9Y4L9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: January 16, 2019
This is version 87 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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