UniProtKB - A4D182 (A4D182_HUMAN)
Protein
Submitted name:
Homeo box A3
Gene
HOXA3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Homeo box A3ImportedSubmitted name: cDNA FLJ36881 fis, clone BGGI12001247, highly similar to HOMEOBOX PROTEIN HOX-A3Imported |
Gene namesi | Name:HOXA3Imported ORF Names:tcag7.183Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 91 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 89 – 180 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 242 – 285 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 38 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 131 – 149 | Pro-richSequence analysisAdd BLAST | 19 | |
Compositional biasi | 156 – 170 | Pro-richSequence analysisAdd BLAST | 15 |
Keywords - Domaini
HomeoboxUniRule annotationImportedARBA annotationFamily and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR025281, DUF4074 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF13293, DUF4074, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A4D182-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKESRQNTKQ KTSSSSSGES CAGDKSPPGQ ASSKRARTAY TSAQLVELEK
60 70 80 90 100
EFHFNRYLCR PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMLTS
110 120 130 140 150
SGGQSPSRSP VPPGAGGYLN SMHSLVNSVP YEPQSPPPFS KPPQGTYGLP
160 170 180 190 200
PASYPASLPS CAPPPPPQKR YTAAGAGAGG TPDYDPHAHG LQGNGSYGTP
210 220 230 240 250
HIQGSPVFVG GSYVEPMSNS GPALFGLTHL PHAASGAMDY GGAGPLGSGH
260 270 280
HHGPGPGEPH PTYTDLTGHH PSQGRIQEAP KLTHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094200 mRNA Translation: BAG52842.1 CH236948 Genomic DNA Translation: EAL24226.1 |
RefSeqi | NP_705895.1, NM_153631.2 |
Genome annotation databases
GeneIDi | 3200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK094200 mRNA Translation: BAG52842.1 CH236948 Genomic DNA Translation: EAL24226.1 |
RefSeqi | NP_705895.1, NM_153631.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | A4D182 |
ProteomicsDBi | 608 |
Protocols and materials databases
DNASUi | 3200 |
Genome annotation databases
GeneIDi | 3200 |
Organism-specific databases
CTDi | 3200 |
PharmGKBi | PA29381 |
Miscellaneous databases
BioGRID-ORCSi | 3200, 9 hits in 1010 CRISPR screens |
ChiTaRSi | HOXA3, human |
GenomeRNAii | 3200 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR025281, DUF4074 IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF13293, DUF4074, 1 hit PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A4D182_HUMAN | |
Accessioni | A4D182Primary (citable) accession number: A4D182 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |