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UniProtKB - A4D0V9 (A4D0V9_HUMAN)
Protein
Potassium voltage-gated channel subfamily D member 2
Gene
KCND2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- A-type (transient outward) potassium channel activity Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential Source: Ensembl
GO - Biological processi
- locomotor rhythm Source: Ensembl
- neuronal action potential Source: Ensembl
- protein homooligomerization Source: InterPro
- regulation of ion transmembrane transport Source: UniProtKB-KW
- sensory perception of pain Source: Ensembl
Keywordsi
Molecular function | Ion channel, Potassium channelARBA annotation, Voltage-gated channelARBA annotation |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Metal-bindingARBA annotation, Potassium |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily D member 2ARBA annotationAlternative name(s): Voltage-gated potassium channel subunit Kv4.2ARBA annotation |
Gene namesi | Name:KCND2Imported ORF Names:hCG_2039708Imported, tcag7.101Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000184408 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- dendrite ARBA annotation
- dendritic spine ARBA annotation
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Perikaryon ARBA annotation
Plasma Membrane
- integral component of postsynaptic specialization membrane Source: Ensembl
- voltage-gated potassium channel complex Source: Ensembl
Other locations
- dendritic spine Source: UniProtKB-SubCell
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 183 – 204 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 224 – 245 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 257 – 279 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 324 – 345 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 357 – 373 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 385 – 406 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Cell projectionARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5014296867 | 17 – 630 | Potassium voltage-gated channel subfamily D member 2Sequence analysisAdd BLAST | 614 |
Keywords - PTMi
PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000184408, Expressed in caudate nucleus and 151 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 140 | BTBInterPro annotationAdd BLAST | 100 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 600 – 630 | DisorderedSequence analysisAdd BLAST | 31 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 416 – 436 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. [View classification]ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_011722_9_1_1 |
OMAi | RTTVEKY |
OrthoDBi | 469107at2759 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004055, K_chnl_volt-dep_Kv4.2 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01517, KV42CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
i Sequence
Sequence statusi: Complete.
A4D0V9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGVAAWLP FARAAAIGWM PVASGPMPAP PRQERKRTQD ALIVLNVSGT
60 70 80 90 100
RFQTWQDTLE RYPDTLLGSS ERDFFYHPET QQYFFDRDPD IFRHILNFYR
110 120 130 140 150
TGKLHYPRHE CISAYDEELA FFGLIPEIIG DCCYEEYKDR RRENAERLQD
160 170 180 190 200
DADTDTAGES ALPTMTARQR VWRAFENPHT STMALVFYYV TGFFIAVSVI
210 220 230 240 250
ANVVETVPCG SSPGHIKELP CGERYAVAFF CLDTACVMIF TVEYLLRLAA
260 270 280 290 300
APSRYRFVRS VMSIIDVVAI LPYYIGLVMT DNEDVSGAFV TLRVFRVFRI
310 320 330 340 350
FKFSRHSQGL RILGYTLKSC ASELGFLLFS LTMAIIIFAT VMFYAEKGSS
360 370 380 390 400
ASKFTSIPAA FWYTIVTMTT LGYGDMVPKT IAGKIFGSIC SLSGVLVIAL
410 420 430 440 450
PVPVIVSNFS RIYHQNQRAD KRRAQKKARL ARIRAAKSGS ANAYMQSKRN
460 470 480 490 500
GLLSNQLQSS EDEQAFVSKS GSSFETQHHH LLHCLEKTTN HEFVDEQVFE
510 520 530 540 550
ESCMEVATVN RPSSHSPSLS SQQGVTSTCC SRRHKKTFRI PNANVSGSHQ
560 570 580 590 600
GSIQELSTIQ IRCVERTPLS NSRSSLNAKM EECVKLNCEQ PYVTTAIISI
610 620 630
PTPPVTTPEG DDRPESPEYS GGNIVRVSAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH236947 Genomic DNA Translation: EAL24350.1 CH471070 Genomic DNA Translation: EAW83541.1 |
RefSeqi | NP_036413.1, NM_012281.2 |
Genome annotation databases
GeneIDi | 3751 |
KEGGi | hsa:3751 |
MANE-Selecti | ENST00000331113.9; ENSP00000333496.4; NM_012281.3; NP_036413.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH236947 Genomic DNA Translation: EAL24350.1 CH471070 Genomic DNA Translation: EAW83541.1 |
RefSeqi | NP_036413.1, NM_012281.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 31683, 438 antibodies from 39 providers |
DNASUi | 3751 |
Genome annotation databases
GeneIDi | 3751 |
KEGGi | hsa:3751 |
MANE-Selecti | ENST00000331113.9; ENSP00000333496.4; NM_012281.3; NP_036413.1 |
Organism-specific databases
CTDi | 3751 |
PharmGKBi | PA30030 |
VEuPathDBi | HostDB:ENSG00000184408 |
Phylogenomic databases
HOGENOMi | CLU_011722_9_1_1 |
OMAi | RTTVEKY |
OrthoDBi | 469107at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3751, 14 hits in 1076 CRISPR screens |
ChiTaRSi | KCND2, human |
GenomeRNAii | 3751 |
Gene expression databases
Bgeei | ENSG00000184408, Expressed in caudate nucleus and 151 other tissues |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit 3.30.710.10, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004055, K_chnl_volt-dep_Kv4.2 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01517, KV42CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A4D0V9_HUMAN | |
Accessioni | A4D0V9Primary (citable) accession number: A4D0V9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |