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Protein

Cadherin-like and PC-esterase domain-containing protein 1

Gene

CPED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-like and PC-esterase domain-containing protein 1
Gene namesi
Name:CPED1
Synonyms:C7orf58
ORF Names:UNQ9432/PRO34713
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106034.17
HGNCiHGNC:26159 CPED1
neXtProtiNX_A4D0V7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi79974
OpenTargetsiENSG00000106034
PharmGKBiPA162380636

Polymorphism and mutation databases

BioMutaiCPED1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000031773235 – 1026Cadherin-like and PC-esterase domain-containing protein 1Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi404N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi791N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi985N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiA4D0V7
MaxQBiA4D0V7
PaxDbiA4D0V7
PRIDEiA4D0V7
ProteomicsDBi598
599 [A4D0V7-2]

PTM databases

iPTMnetiA4D0V7
PhosphoSitePlusiA4D0V7

Expressioni

Gene expression databases

BgeeiENSG00000106034 Expressed in 200 organ(s), highest expression level in cauda epididymis
CleanExiHS_C7orf58
ExpressionAtlasiA4D0V7 baseline and differential
GenevisibleiA4D0V7 HS

Organism-specific databases

HPAiHPA012058

Interactioni

Protein-protein interaction databases

BioGridi123041, 1 interactor
IntActiA4D0V7, 1 interactor
STRINGi9606.ENSP00000309772

Structurei

3D structure databases

ProteinModelPortaliA4D0V7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PC-esterase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEF4 Eukaryota
ENOG4110TQ2 LUCA
GeneTreeiENSGT00390000015216
HOVERGENiHBG095603
InParanoidiA4D0V7
OMAiEGLCQII
OrthoDBiEOG091G08E5
PhylomeDBiA4D0V7
TreeFamiTF332741

Family and domain databases

InterProiView protein in InterPro
IPR025883 Cadherin-like_b_sandwich
PfamiView protein in Pfam
PF12733 Cadherin-like, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A4D0V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP
60 70 80 90 100
HTSTETQASR CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI
110 120 130 140 150
LYRPPFYSKT ELQLHQHILT QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW
160 170 180 190 200
DLLICLSSKK AEGTPCISKE VMCQLGLHQK ANRLPEIQQP LCRKEGLCQI
210 220 230 240 250
VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW KPGDWSREQL
260 270 280 290 300
NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
310 320 330 340 350
KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK
360 370 380 390 400
TFHRCRFCFQ LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE
410 420 430 440 450
FLLNDTFNFL FPNESSLSIF SEIFQRLYRS DVFKGENYQK ELNQCLSLEE
460 470 480 490 500
INSIMTFIKE LGSLGQFQLL FPSTTPGIQS LMHEFYDVAN PVGNPGSVLT
510 520 530 540 550
QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV PFDAIENKKA
560 570 580 590 600
AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
610 620 630 640 650
PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES
660 670 680 690 700
PAHGETLITY KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ
710 720 730 740 750
PISSDYIEAI LQSELKRCPS GDMKGQWIVP CLSCSDNRTC DWREITWQPH
760 770 780 790 800
NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR GIMYYLIERL NETLQEWQKV
810 820 830 840 850
HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH LLQRSRPLEN
860 870 880 890 900
TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
910 920 930 940 950
GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC
960 970 980 990 1000
GCHFHEVVKS KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP
1010 1020
YHVRGPINQV CSEILLSRMC ANKRTM
Length:1,026
Mass (Da):117,491
Last modified:April 3, 2007 - v1
Checksum:i7C3E91FAF7494440
GO
Isoform 2 (identifier: A4D0V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     771-783: ILFIGDSTNRGIM → LGVDVQRVPRSRN
     784-1026: Missing.

Note: No experimental confirmation available.
Show »
Length:783
Mass (Da):89,175
Checksum:i3BE8B0AA01D1FB0B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9U2G5E9U2_HUMAN
Cadherin-like and PC-esterase domai...
CPED1 FLJ21986, hCG_1812950
563Annotation score:
Q5MJQ4Q5MJQ4_HUMAN
Cadherin-like and PC-esterase domai...
CPED1
202Annotation score:
E9PCC8E9PCC8_HUMAN
Cadherin-like and PC-esterase domai...
CPED1
334Annotation score:
E7ENG7E7ENG7_HUMAN
Cadherin-like and PC-esterase domai...
CPED1
549Annotation score:
H0YB19H0YB19_HUMAN
Cadherin-like and PC-esterase domai...
CPED1
60Annotation score:

Sequence cautioni

The sequence AAH30538 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173C → R in CAD89961 (PubMed:17974005).Curated1
Sequence conflicti186E → G in BAF82667 (PubMed:14702039).Curated1
Sequence conflicti262I → T in CAD89961 (PubMed:17974005).Curated1
Sequence conflicti641K → R in CAD89961 (PubMed:17974005).Curated1
Sequence conflicti795Q → R in CAD89961 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038664326I → T. Corresponds to variant dbSNP:rs17143165Ensembl.1
Natural variantiVAR_038665551A → G3 PublicationsCorresponds to variant dbSNP:rs41281692Ensembl.1
Natural variantiVAR_038666708E → G2 PublicationsCorresponds to variant dbSNP:rs35793694Ensembl.1
Natural variantiVAR_038667949K → T. Corresponds to variant dbSNP:rs798911Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031140771 – 783ILFIG…NRGIM → LGVDVQRVPRSRN in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_031141784 – 1026Missing in isoform 2. 2 PublicationsAdd BLAST243

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358220 mRNA Translation: AAQ88587.1
AK055624 mRNA Translation: BAB70974.1
AK289978 mRNA Translation: BAF82667.1
AL832619 mRNA Translation: CAD89961.1
AL832638 mRNA Translation: CAD89953.1
CH236947 Genomic DNA Translation: EAL24348.1
BC030538 mRNA Translation: AAH30538.1 Different initiation.
CCDSiCCDS34739.1 [A4D0V7-1]
CCDS47690.1 [A4D0V7-2]
RefSeqiNP_001099003.1, NM_001105533.1 [A4D0V7-2]
NP_079189.4, NM_024913.4 [A4D0V7-1]
UniGeneiHs.189652

Genome annotation databases

EnsembliENST00000310396; ENSP00000309772; ENSG00000106034 [A4D0V7-1]
ENST00000450913; ENSP00000406122; ENSG00000106034 [A4D0V7-2]
GeneIDi79974
KEGGihsa:79974
UCSCiuc003vjq.5 human [A4D0V7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358220 mRNA Translation: AAQ88587.1
AK055624 mRNA Translation: BAB70974.1
AK289978 mRNA Translation: BAF82667.1
AL832619 mRNA Translation: CAD89961.1
AL832638 mRNA Translation: CAD89953.1
CH236947 Genomic DNA Translation: EAL24348.1
BC030538 mRNA Translation: AAH30538.1 Different initiation.
CCDSiCCDS34739.1 [A4D0V7-1]
CCDS47690.1 [A4D0V7-2]
RefSeqiNP_001099003.1, NM_001105533.1 [A4D0V7-2]
NP_079189.4, NM_024913.4 [A4D0V7-1]
UniGeneiHs.189652

3D structure databases

ProteinModelPortaliA4D0V7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123041, 1 interactor
IntActiA4D0V7, 1 interactor
STRINGi9606.ENSP00000309772

PTM databases

iPTMnetiA4D0V7
PhosphoSitePlusiA4D0V7

Polymorphism and mutation databases

BioMutaiCPED1

Proteomic databases

EPDiA4D0V7
MaxQBiA4D0V7
PaxDbiA4D0V7
PRIDEiA4D0V7
ProteomicsDBi598
599 [A4D0V7-2]

Protocols and materials databases

DNASUi79974
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310396; ENSP00000309772; ENSG00000106034 [A4D0V7-1]
ENST00000450913; ENSP00000406122; ENSG00000106034 [A4D0V7-2]
GeneIDi79974
KEGGihsa:79974
UCSCiuc003vjq.5 human [A4D0V7-1]

Organism-specific databases

CTDi79974
DisGeNETi79974
EuPathDBiHostDB:ENSG00000106034.17
GeneCardsiCPED1
H-InvDBiHIX0201130
HGNCiHGNC:26159 CPED1
HPAiHPA012058
neXtProtiNX_A4D0V7
OpenTargetsiENSG00000106034
PharmGKBiPA162380636
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEF4 Eukaryota
ENOG4110TQ2 LUCA
GeneTreeiENSGT00390000015216
HOVERGENiHBG095603
InParanoidiA4D0V7
OMAiEGLCQII
OrthoDBiEOG091G08E5
PhylomeDBiA4D0V7
TreeFamiTF332741

Miscellaneous databases

ChiTaRSiCPED1 human
GeneWikiiFLJ21986
GenomeRNAii79974
PROiPR:A4D0V7

Gene expression databases

BgeeiENSG00000106034 Expressed in 200 organ(s), highest expression level in cauda epididymis
CleanExiHS_C7orf58
ExpressionAtlasiA4D0V7 baseline and differential
GenevisibleiA4D0V7 HS

Family and domain databases

InterProiView protein in InterPro
IPR025883 Cadherin-like_b_sandwich
PfamiView protein in Pfam
PF12733 Cadherin-like, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCPED1_HUMAN
AccessioniPrimary (citable) accession number: A4D0V7
Secondary accession number(s): A8K1R3
, Q6UXT1, Q86T76, Q86T84, Q8N2T5, Q96NC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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