UniProtKB - A4D0V7 (CPED1_HUMAN)
Protein
Cadherin-like and PC-esterase domain-containing protein 1
Gene
CPED1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-like and PC-esterase domain-containing protein 1 |
Gene namesi | Name:CPED1 Synonyms:C7orf58 ORF Names:UNQ9432/PRO34713 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26159, CPED1 |
neXtProti | NX_A4D0V7 |
VEuPathDBi | HostDB:ENSG00000106034.17 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79974 |
OpenTargetsi | ENSG00000106034 |
PharmGKBi | PA162380636 |
Miscellaneous databases
Pharosi | A4D0V7, Tdark |
Genetic variation databases
BioMutai | CPED1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000317732 | 35 – 1026 | Cadherin-like and PC-esterase domain-containing protein 1Add BLAST | 992 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 404 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 413 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 737 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 791 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 985 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | A4D0V7 |
MassIVEi | A4D0V7 |
MaxQBi | A4D0V7 |
PaxDbi | A4D0V7 |
PeptideAtlasi | A4D0V7 |
PRIDEi | A4D0V7 |
ProteomicsDBi | 598 [A4D0V7-1] 599 [A4D0V7-2] |
PTM databases
GlyGeni | A4D0V7, 6 sites |
iPTMneti | A4D0V7 |
PhosphoSitePlusi | A4D0V7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106034, Expressed in cauda epididymis and 213 other tissues |
ExpressionAtlasi | A4D0V7, baseline and differential |
Genevisiblei | A4D0V7, HS |
Organism-specific databases
HPAi | ENSG00000106034, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123041, 1 interactor |
IntActi | A4D0V7, 1 interactor |
STRINGi | 9606.ENSP00000309772 |
Miscellaneous databases
RNActi | A4D0V7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the PC-esterase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQAY, Eukaryota |
GeneTreei | ENSGT00390000015216 |
HOGENOMi | CLU_011328_0_0_1 |
InParanoidi | A4D0V7 |
OMAi | HRCRLCF |
OrthoDBi | 469326at2759 |
PhylomeDBi | A4D0V7 |
TreeFami | TF332741 |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A4D0V7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP
60 70 80 90 100
HTSTETQASR CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI
110 120 130 140 150
LYRPPFYSKT ELQLHQHILT QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW
160 170 180 190 200
DLLICLSSKK AEGTPCISKE VMCQLGLHQK ANRLPEIQQP LCRKEGLCQI
210 220 230 240 250
VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW KPGDWSREQL
260 270 280 290 300
NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
310 320 330 340 350
KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK
360 370 380 390 400
TFHRCRFCFQ LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE
410 420 430 440 450
FLLNDTFNFL FPNESSLSIF SEIFQRLYRS DVFKGENYQK ELNQCLSLEE
460 470 480 490 500
INSIMTFIKE LGSLGQFQLL FPSTTPGIQS LMHEFYDVAN PVGNPGSVLT
510 520 530 540 550
QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV PFDAIENKKA
560 570 580 590 600
AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
610 620 630 640 650
PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES
660 670 680 690 700
PAHGETLITY KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ
710 720 730 740 750
PISSDYIEAI LQSELKRCPS GDMKGQWIVP CLSCSDNRTC DWREITWQPH
760 770 780 790 800
NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR GIMYYLIERL NETLQEWQKV
810 820 830 840 850
HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH LLQRSRPLEN
860 870 880 890 900
TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
910 920 930 940 950
GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC
960 970 980 990 1000
GCHFHEVVKS KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP
1010 1020
YHVRGPINQV CSEILLSRMC ANKRTM
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9U2 | G5E9U2_HUMAN | Cadherin-like and PC-esterase domai... | CPED1 FLJ21986, hCG_1812950 | 563 | Annotation score: | ||
Q5MJQ4 | Q5MJQ4_HUMAN | Cadherin-like and PC-esterase domai... | CPED1 | 202 | Annotation score: | ||
E9PCC8 | E9PCC8_HUMAN | Cadherin-like and PC-esterase domai... | CPED1 | 334 | Annotation score: | ||
E7ENG7 | E7ENG7_HUMAN | Cadherin-like and PC-esterase domai... | CPED1 | 549 | Annotation score: | ||
H0YB19 | H0YB19_HUMAN | Cadherin-like and PC-esterase domai... | CPED1 | 60 | Annotation score: |
Sequence cautioni
The sequence AAH30538 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 173 | C → R in CAD89961 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 186 | E → G in BAF82667 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 262 | I → T in CAD89961 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 641 | K → R in CAD89961 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 795 | Q → R in CAD89961 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038664 | 326 | I → T. Corresponds to variant dbSNP:rs17143165Ensembl. | 1 | |
Natural variantiVAR_038665 | 551 | A → G3 PublicationsCorresponds to variant dbSNP:rs41281692Ensembl. | 1 | |
Natural variantiVAR_038666 | 708 | E → G2 PublicationsCorresponds to variant dbSNP:rs35793694Ensembl. | 1 | |
Natural variantiVAR_038667 | 949 | K → T. Corresponds to variant dbSNP:rs798911EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031140 | 771 – 783 | ILFIG…NRGIM → LGVDVQRVPRSRN in isoform 2. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_031141 | 784 – 1026 | Missing in isoform 2. 2 PublicationsAdd BLAST | 243 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358220 mRNA Translation: AAQ88587.1 AK055624 mRNA Translation: BAB70974.1 AK289978 mRNA Translation: BAF82667.1 AL832619 mRNA Translation: CAD89961.1 AL832638 mRNA Translation: CAD89953.1 CH236947 Genomic DNA Translation: EAL24348.1 BC030538 mRNA Translation: AAH30538.1 Different initiation. |
CCDSi | CCDS34739.1 [A4D0V7-1] CCDS47690.1 [A4D0V7-2] |
RefSeqi | NP_001099003.1, NM_001105533.1 [A4D0V7-2] NP_079189.4, NM_024913.4 [A4D0V7-1] |
Genome annotation databases
Ensembli | ENST00000310396; ENSP00000309772; ENSG00000106034 [A4D0V7-1] ENST00000450913; ENSP00000406122; ENSG00000106034 [A4D0V7-2] |
GeneIDi | 79974 |
KEGGi | hsa:79974 |
UCSCi | uc003vjq.5, human [A4D0V7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358220 mRNA Translation: AAQ88587.1 AK055624 mRNA Translation: BAB70974.1 AK289978 mRNA Translation: BAF82667.1 AL832619 mRNA Translation: CAD89961.1 AL832638 mRNA Translation: CAD89953.1 CH236947 Genomic DNA Translation: EAL24348.1 BC030538 mRNA Translation: AAH30538.1 Different initiation. |
CCDSi | CCDS34739.1 [A4D0V7-1] CCDS47690.1 [A4D0V7-2] |
RefSeqi | NP_001099003.1, NM_001105533.1 [A4D0V7-2] NP_079189.4, NM_024913.4 [A4D0V7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123041, 1 interactor |
IntActi | A4D0V7, 1 interactor |
STRINGi | 9606.ENSP00000309772 |
PTM databases
GlyGeni | A4D0V7, 6 sites |
iPTMneti | A4D0V7 |
PhosphoSitePlusi | A4D0V7 |
Genetic variation databases
BioMutai | CPED1 |
Proteomic databases
jPOSTi | A4D0V7 |
MassIVEi | A4D0V7 |
MaxQBi | A4D0V7 |
PaxDbi | A4D0V7 |
PeptideAtlasi | A4D0V7 |
PRIDEi | A4D0V7 |
ProteomicsDBi | 598 [A4D0V7-1] 599 [A4D0V7-2] |
Protocols and materials databases
Antibodypediai | 2305, 45 antibodies |
DNASUi | 79974 |
Genome annotation databases
Ensembli | ENST00000310396; ENSP00000309772; ENSG00000106034 [A4D0V7-1] ENST00000450913; ENSP00000406122; ENSG00000106034 [A4D0V7-2] |
GeneIDi | 79974 |
KEGGi | hsa:79974 |
UCSCi | uc003vjq.5, human [A4D0V7-1] |
Organism-specific databases
CTDi | 79974 |
DisGeNETi | 79974 |
GeneCardsi | CPED1 |
HGNCi | HGNC:26159, CPED1 |
HPAi | ENSG00000106034, Low tissue specificity |
neXtProti | NX_A4D0V7 |
OpenTargetsi | ENSG00000106034 |
PharmGKBi | PA162380636 |
VEuPathDBi | HostDB:ENSG00000106034.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQAY, Eukaryota |
GeneTreei | ENSGT00390000015216 |
HOGENOMi | CLU_011328_0_0_1 |
InParanoidi | A4D0V7 |
OMAi | HRCRLCF |
OrthoDBi | 469326at2759 |
PhylomeDBi | A4D0V7 |
TreeFami | TF332741 |
Enzyme and pathway databases
PathwayCommonsi | A4D0V7 |
Miscellaneous databases
BioGRID-ORCSi | 79974, 8 hits in 991 CRISPR screens |
ChiTaRSi | CPED1, human |
GeneWikii | FLJ21986 |
GenomeRNAii | 79974 |
Pharosi | A4D0V7, Tdark |
PROi | PR:A4D0V7 |
RNActi | A4D0V7, protein |
Gene expression databases
Bgeei | ENSG00000106034, Expressed in cauda epididymis and 213 other tissues |
ExpressionAtlasi | A4D0V7, baseline and differential |
Genevisiblei | A4D0V7, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CPED1_HUMAN | |
Accessioni | A4D0V7Primary (citable) accession number: A4D0V7 Secondary accession number(s): A8K1R3 Q96NC9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | April 3, 2007 | |
Last modified: | April 7, 2021 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families