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Entry version 103 (08 May 2019)
Sequence version 1 (03 Apr 2007)
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Protein

Laminin subunit beta-4

Gene

LAMB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-4
Alternative name(s):
Laminin beta-1-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6491 LAMB4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616380 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A4D0S4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22798

Open Targets

More...
OpenTargetsi
ENSG00000091128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30279

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364187

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAMB4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031285720 – 1761Laminin subunit beta-4Add BLAST1742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi265 ↔ ?274PROSITE-ProRule annotation
Disulfide bondi267 ↔ 295PROSITE-ProRule annotation
Disulfide bondi297 ↔ 306PROSITE-ProRule annotation
Disulfide bondi309 ↔ 329PROSITE-ProRule annotation
Disulfide bondi332 ↔ 341PROSITE-ProRule annotation
Disulfide bondi334 ↔ 359PROSITE-ProRule annotation
Disulfide bondi362 ↔ 371PROSITE-ProRule annotation
Disulfide bondi374 ↔ 392PROSITE-ProRule annotation
Disulfide bondi395 ↔ 408PROSITE-ProRule annotation
Disulfide bondi397 ↔ 423PROSITE-ProRule annotation
Disulfide bondi425 ↔ 434PROSITE-ProRule annotation
Disulfide bondi437 ↔ 452PROSITE-ProRule annotation
Disulfide bondi455 ↔ 468PROSITE-ProRule annotation
Disulfide bondi457 ↔ 475PROSITE-ProRule annotation
Disulfide bondi477 ↔ 486PROSITE-ProRule annotation
Disulfide bondi489 ↔ 503PROSITE-ProRule annotation
Disulfide bondi506 ↔ 518PROSITE-ProRule annotation
Disulfide bondi508 ↔ 525PROSITE-ProRule annotation
Disulfide bondi527 ↔ 536PROSITE-ProRule annotation
Disulfide bondi769 ↔ 781PROSITE-ProRule annotation
Disulfide bondi771 ↔ 788PROSITE-ProRule annotation
Disulfide bondi790 ↔ 799PROSITE-ProRule annotation
Disulfide bondi802 ↔ 814PROSITE-ProRule annotation
Disulfide bondi817 ↔ 829PROSITE-ProRule annotation
Disulfide bondi819 ↔ 836PROSITE-ProRule annotation
Disulfide bondi838 ↔ 847PROSITE-ProRule annotation
Disulfide bondi850 ↔ 860PROSITE-ProRule annotation
Disulfide bondi863 ↔ 872PROSITE-ProRule annotation
Disulfide bondi865 ↔ 879PROSITE-ProRule annotation
Disulfide bondi882 ↔ 891PROSITE-ProRule annotation
Disulfide bondi894 ↔ 908PROSITE-ProRule annotation
Disulfide bondi913 ↔ 938PROSITE-ProRule annotation
Disulfide bondi940 ↔ 949PROSITE-ProRule annotation
Disulfide bondi952 ↔ 967PROSITE-ProRule annotation
Disulfide bondi970 ↔ 984PROSITE-ProRule annotation
Disulfide bondi972 ↔ 991PROSITE-ProRule annotation
Disulfide bondi994 ↔ 1003PROSITE-ProRule annotation
Disulfide bondi1006 ↔ 1019PROSITE-ProRule annotation
Glycosylationi1016N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1022 ↔ 1043PROSITE-ProRule annotation
Disulfide bondi1024 ↔ 1050PROSITE-ProRule annotation
Disulfide bondi1052 ↔ 1061PROSITE-ProRule annotation
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1064 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1080 ↔ 1092PROSITE-ProRule annotation
Disulfide bondi1082 ↔ 1099PROSITE-ProRule annotation
Disulfide bondi1101 ↔ 1110PROSITE-ProRule annotation
Disulfide bondi1113 ↔ 1125PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1140PROSITE-ProRule annotation
Disulfide bondi1130 ↔ 1147PROSITE-ProRule annotation
Disulfide bondi1149 ↔ 1158PROSITE-ProRule annotation
Disulfide bondi1161 ↔ 1172PROSITE-ProRule annotation
Disulfide bondi1175InterchainCurated
Disulfide bondi1178InterchainCurated
Glycosylationi1223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1354N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1517N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1587N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1596N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1725N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1759InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A4D0S4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A4D0S4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A4D0S4

PRoteomics IDEntifications database

More...
PRIDEi
A4D0S4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
592
593 [A4D0S4-2]
594 [A4D0S4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A4D0S4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A4D0S4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000091128 Expressed in 83 organ(s), highest expression level in skin of abdomen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A4D0S4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A4D0S4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020242
HPA024247

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116479, 3 interactors

Protein interaction database and analysis system

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IntActi
A4D0S4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373433

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A4D0S4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 264Laminin N-terminalPROSITE-ProRule annotationAdd BLAST241
Domaini265 – 331Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST67
Domaini332 – 394Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini395 – 454Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini455 – 505Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST51
Domaini506 – 552Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST47
Domaini545 – 763Laminin IV type BPROSITE-ProRule annotationAdd BLAST219
Domaini769 – 816Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini817 – 862Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini863 – 910Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST48
Domaini911 – 969Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST59
Domaini970 – 1021Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1022 – 1079Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST58
Domaini1080 – 1127Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1128 – 1174Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1175 – 1375Domain IIAdd BLAST201
Regioni1376 – 1408Domain alphaAdd BLAST33
Regioni1409 – 1761Domain IAdd BLAST353

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1243 – 1301Sequence analysisAdd BLAST59
Coiled coili1416 – 1480Sequence analysisAdd BLAST65
Coiled coili1525 – 1759Sequence analysisAdd BLAST235

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994 Eukaryota
ENOG410XPEG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162514

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A4D0S4

KEGG Orthology (KO)

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KOi
K06245

Identification of Orthologs from Complete Genome Data

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OMAi
YGHTWKV

Database of Orthologous Groups

More...
OrthoDBi
65841at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A4D0S4

TreeFam database of animal gene trees

More...
TreeFami
TF312903

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 12 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A4D0S4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQFQLTLFLH LGWLSYSKAQ DDCNRGACHP TTGDLLVGRN TQLMASSTCG
60 70 80 90 100
LSRAQKYCIL SYLEGEQKCF ICDSRFPYDP YDQPNSHTIE NVIVSFEPDR
110 120 130 140 150
EKKWWQSENG LDHVSIRLDL EALFRFSHLI LTFKTFRPAA MLVERSTDYG
160 170 180 190 200
HNWKVFKYFA KDCATSFPNI TSGQAQGVGD IVCDSKYSDI EPSTGGEVVL
210 220 230 240 250
KVLDPSFEIE NPYSPYIQDL VTLTNLRINF TKLHTLGDAL LGRRQNDSLD
260 270 280 290 300
KYYYALYEMI VRGSCFCNGH ASECRPMQKM RGDVFSPPGM VHGQCVCQHN
310 320 330 340 350
TDGPNCERCK DFFQDAPWRP AADLQDNACR SCSCNSHSSR CHFDMTTYLA
360 370 380 390 400
SGGLSGGVCE DCQHNTEGQH CDRCRPLFYR DPLKTISDPY ACIPCECDPD
410 420 430 440 450
GTISGGICVS HSDPALGSVA GQCLCKENVE GAKCDQCKPN HYGLSATDPL
460 470 480 490 500
GCQPCDCNPL GSLPFLTCDV DTGQCLCLSY VTGAHCEECT VGYWGLGNHL
510 520 530 540 550
HGCSPCDCDI GGAYSNVCSP KNGQCECRPH VTGRSCSEPA PGYFFAPLNF
560 570 580 590 600
YLYEAEEATT LQGLAPLGSE TFGQSPAVHV VLGEPVPGNP VTWTGPGFAR
610 620 630 640 650
VLPGAGLRFA VNNIPFPVDF TIAIHYETQS AADWTVQIVV NPPGGSEHCI
660 670 680 690 700
PKTLQSKPQS FALPAATRIM LLPTPICLEP DVQYSIDVYF SQPLQGESHA
710 720 730 740 750
HSHVLVDSLG LIPQINSLEN FCSKQDLDEY QLHNCVEIAS AMGPQVLPGA
760 770 780 790 800
CERLIISMSA KLHDGAVACK CHPQGSVGSS CSRLGGQCQC KPLVVGRCCD
810 820 830 840 850
RCSTGSYDLG HHGCHPCHCH PQGSKDTVCD QVTGQCPCHG EVSGRRCDRC
860 870 880 890 900
LAGYFGFPSC HPCPCNRFAE LCDPETGSCF NCGGFTTGRN CERCIDGYYG
910 920 930 940 950
NPSSGQPCRP CLCPDDPSSN QYFAHSCYQN LWSSDVICNC LQGYTGTQCG
960 970 980 990 1000
ECSTGFYGNP RISGAPCQPC ACNNNIDVTD PESCSRVTGE CLRCLHNTQG
1010 1020 1030 1040 1050
ANCQLCKPGH YGSALNQTCR RCSCHASGVS PMECPPGGGA CLCDPVTGAC
1060 1070 1080 1090 1100
PCLPNVTGLA CDRCADGYWN LVPGRGCQSC DCDPRTSQSS HCDQLTGQCP
1110 1120 1130 1140 1150
CKLGYGGKRC SECQENYYGD PPGRCIPCDC NRAGTQKPIC DPDTGMCRCR
1160 1170 1180 1190 1200
EGVSGQRCDR CARGHSQEFP TCLQCHLCFD QWDHTISSLS KAVQGLMRLA
1210 1220 1230 1240 1250
ANMEDKRETL PVCEADFKDL RGNVSEIERI LKHPVFPSGK FLKVKDYHDS
1260 1270 1280 1290 1300
VRRQIMQLNE QLKAVYEFQD LKDTIERAKN EADLLLEDLQ EEIDLQSSVL
1310 1320 1330 1340 1350
NASIADSSEN IKKYYHISSS AEKKINETSS TINTSANTRN DLLTILDTLT
1360 1370 1380 1390 1400
SKGNLSLERL KQIKIPDIQI LNEKVCGDPG NVPCVPLPCG GALCTGRKGH
1410 1420 1430 1440 1450
RKCRGPGCHG SLTLSTNALQ KAQEAKSIIR NLDKQVRGLK NQIESISEQA
1460 1470 1480 1490 1500
EVSKNNALQL REKLGNIRNQ SDSEEENINL FIKKVKNFLL EENVPPEDIE
1510 1520 1530 1540 1550
KVANGVLDIH LPIPSQNLTD ELVKIQKHMQ LCEDYRTDEN RLNEEADGAQ
1560 1570 1580 1590 1600
KLLVKAKAAE KAANILLNLD KTLNQLQQAQ ITQGRANSTI TQLTANITKI
1610 1620 1630 1640 1650
KKNVLQAENQ TREMKSELEL AKQRSGLEDG LSLLQTKLQR HQDHAVNAKV
1660 1670 1680 1690 1700
QAESAQHQAG SLEKEFVELK KQYAILQRKT STTGLTKETL GKVKQLKDAA
1710 1720 1730 1740 1750
EKLAGDTEAK IRRITDLERK IQDLNLSRQA KADQLRILED QVVAIKNEIV
1760
EQEKKYARCY S
Length:1,761
Mass (Da):193,540
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57A740F079CE1FB2
GO
Isoform 2 (identifier: A4D0S4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     709-772: LGLIPQINSL...HDGAVACKCH → AAVQWHNLGS...PGWSRTPDLR
     773-1761: Missing.

Show »
Length:772
Mass (Da):85,105
Checksum:iB74332DD472E0C6B
GO
Isoform 3 (identifier: A4D0S4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1716-1723: DLERKIQD → GCFQNSAR
     1724-1761: Missing.

Show »
Length:1,723
Mass (Da):188,959
Checksum:iEF23F9CBED1266A7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JMJ0C9JMJ0_HUMAN
Laminin subunit beta-4
LAMB4
772Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG90A0A0C4DG90_HUMAN
Laminin subunit beta-4
LAMB4
749Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70F → S in AAC95123 (Ref. 1) Curated1
Sequence conflicti93I → T in AAC95123 (Ref. 1) Curated1
Sequence conflicti1542L → S in AAC95123 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03758844M → T. Corresponds to variant dbSNP:rs35644375Ensembl.1
Natural variantiVAR_037589234H → Y. Corresponds to variant dbSNP:rs2074749Ensembl.1
Natural variantiVAR_037590591V → F. Corresponds to variant dbSNP:rs9690688Ensembl.1
Natural variantiVAR_037591866N → S. Corresponds to variant dbSNP:rs2240445Ensembl.1
Natural variantiVAR_0741741028G → C1 PublicationCorresponds to variant dbSNP:rs1299564647Ensembl.1
Natural variantiVAR_0375921350T → N. Corresponds to variant dbSNP:rs10260756Ensembl.1
Natural variantiVAR_0375931510H → Y. Corresponds to variant dbSNP:rs1627354Ensembl.1
Natural variantiVAR_0375941612R → S. Corresponds to variant dbSNP:rs2528693Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029913709 – 772LGLIP…ACKCH → AAVQWHNLGSLQPPPPECKQ FSCFSFPSSWDYRHPPPHLA SFCIFSRDGVSPHWPGWSRT PDLR in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_029914773 – 1761Missing in isoform 2. 1 PublicationAdd BLAST989
Alternative sequenceiVSP_0299151716 – 1723DLERKIQD → GCFQNSAR in isoform 3. 1 Publication8
Alternative sequenceiVSP_0299161724 – 1761Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF028816 mRNA Translation: AAC95123.1
AC005048 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24387.1
BC045172 mRNA Translation: AAH45172.2
BC140804 mRNA Translation: AAI40805.1
BC142619 mRNA Translation: AAI42620.1
AK075165 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34732.1 [A4D0S4-1]
CCDS83218.1 [A4D0S4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001304975.1, NM_001318046.1 [A4D0S4-1]
NP_001304977.1, NM_001318048.1
NP_031382.2, NM_007356.2 [A4D0S4-1]
XP_011514280.1, XM_011515978.1 [A4D0S4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000205386; ENSP00000205386; ENSG00000091128 [A4D0S4-1]
ENST00000388781; ENSP00000373433; ENSG00000091128 [A4D0S4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22798

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22798

UCSC genome browser

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UCSCi
uc003vey.3 human [A4D0S4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028816 mRNA Translation: AAC95123.1
AC005048 Genomic DNA No translation available.
CH236947 Genomic DNA Translation: EAL24387.1
BC045172 mRNA Translation: AAH45172.2
BC140804 mRNA Translation: AAI40805.1
BC142619 mRNA Translation: AAI42620.1
AK075165 mRNA No translation available.
CCDSiCCDS34732.1 [A4D0S4-1]
CCDS83218.1 [A4D0S4-2]
RefSeqiNP_001304975.1, NM_001318046.1 [A4D0S4-1]
NP_001304977.1, NM_001318048.1
NP_031382.2, NM_007356.2 [A4D0S4-1]
XP_011514280.1, XM_011515978.1 [A4D0S4-3]

3D structure databases

SMRiA4D0S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116479, 3 interactors
IntActiA4D0S4, 1 interactor
STRINGi9606.ENSP00000373433

Chemistry databases

ChEMBLiCHEMBL2364187

PTM databases

iPTMnetiA4D0S4
PhosphoSitePlusiA4D0S4

Polymorphism and mutation databases

BioMutaiLAMB4

Proteomic databases

EPDiA4D0S4
jPOSTiA4D0S4
PaxDbiA4D0S4
PRIDEiA4D0S4
ProteomicsDBi592
593 [A4D0S4-2]
594 [A4D0S4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000205386; ENSP00000205386; ENSG00000091128 [A4D0S4-1]
ENST00000388781; ENSP00000373433; ENSG00000091128 [A4D0S4-1]
GeneIDi22798
KEGGihsa:22798
UCSCiuc003vey.3 human [A4D0S4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22798
DisGeNETi22798

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAMB4
HGNCiHGNC:6491 LAMB4
HPAiHPA020242
HPA024247
MIMi616380 gene
neXtProtiNX_A4D0S4
OpenTargetsiENSG00000091128
PharmGKBiPA30279

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00940000162514
InParanoidiA4D0S4
KOiK06245
OMAiYGHTWKV
OrthoDBi65841at2759
PhylomeDBiA4D0S4
TreeFamiTF312903

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMB4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22798

Protein Ontology

More...
PROi
PR:A4D0S4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000091128 Expressed in 83 organ(s), highest expression level in skin of abdomen
ExpressionAtlasiA4D0S4 baseline and differential
GenevisibleiA4D0S4 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 12 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A4D0S4
Secondary accession number(s): A5PKU6
, B2RTT3, B5MEB9, Q86TP7, Q86XN2, Q8NBX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 3, 2007
Last modified: May 8, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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