Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 59 (31 Jul 2019)
Sequence version 1 (03 Apr 2007)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Kon-tiki

Gene

Kon

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Kon-tikiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KonImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2200 – 2221HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500265893528 – 2381Sequence analysisAdd BLAST2354

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0032683 Expressed in 20 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
inaDQ240083EBI-4306640,EBI-195326

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
A3RLX3, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 200LAM_G_DOMAINInterPro annotationAdd BLAST174
Domaini201 – 384LAM_G_DOMAINInterPro annotationAdd BLAST184
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati437 – 536CSPGPROSITE-ProRule annotationAdd BLAST100
Repeati568 – 662CSPGPROSITE-ProRule annotationAdd BLAST95
Repeati681 – 776CSPGPROSITE-ProRule annotationAdd BLAST96
Repeati793 – 892CSPGPROSITE-ProRule annotationAdd BLAST100
Repeati916 – 1008CSPGPROSITE-ProRule annotationAdd BLAST93
Repeati1033 – 1122CSPGPROSITE-ProRule annotationAdd BLAST90
Repeati1265 – 1359CSPGPROSITE-ProRule annotationAdd BLAST95
Repeati1377 – 1465CSPGPROSITE-ProRule annotationAdd BLAST89
Repeati1487 – 1578CSPGPROSITE-ProRule annotationAdd BLAST92
Repeati1595 – 1691CSPGPROSITE-ProRule annotationAdd BLAST97
Repeati1714 – 1809CSPGPROSITE-ProRule annotationAdd BLAST96
Repeati1833 – 1932CSPGPROSITE-ProRule annotationAdd BLAST100
Repeati1950 – 2038CSPGPROSITE-ProRule annotationAdd BLAST89
Repeati2055 – 2164CSPGPROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2234 – 2281DisorderedSequence analysisAdd BLAST48

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3597 Eukaryota
ENOG410XQ29 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02210 Laminin_G_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854 CSPG, 14 hits
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A3RLX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRLRGLGFG WLWLAWLAIL QLQTVAAMKV SLFGDGYVSM PLQEAKMSTN
60 70 80 90 100
IRVKFRTRQE NAFLFLAAGR TDYCLLRLES GLISFSYKIE RDVVQLRSPK
110 120 130 140 150
KQKLNDLEWH DVAVQRFENN ITLQVDGYIM RKQLPGDLAA LNIHFGTFLG
160 170 180 190 200
GVGDFTAEFL DDVIGFRGCI SDVFYNNINI IKRAKDRTSH TTSTGVAWTC
210 220 230 240 250
STEFEGSIQD SISFMRNDSY SLMMKESYAM GETLSLQFRT MASAGVIFFN
260 270 280 290 300
GGFDFILLEI EDQHLKVTFN KAGSLVQFMT NEHISDGKWH RVFLRYNAAI
310 320 330 340 350
AELILDDATS GYRGTHANET KASINLEKSV FFGGVQEEMR RRLISKGLRI
360 370 380 390 400
NEISFKGCMR DILVNDLPLG FAEMTISRSL ALNCLWKYPC VEYNPCLKSG
410 420 430 440 450
ICSQHGVDGF ICYCDQSYCI KADFQGPFKI FTETSPELEL LYVSPMQLLE
460 470 480 490 500
GGTAFLSPHF IDIILDLRRY PSLNEQSIIF HVVHQPKYGQ LLQYSAEKAI
510 520 530 540 550
FVPCRTFNLV DLATDKLKYV HNGQENFNDH ATLDMQIFGD VHKIPDNILG
560 570 580 590 600
KHRFLLHANI TPINDPPQLR LHSHKILRVI EGIERVLDVD LFNIDDPDSE
610 620 630 640 650
PGNLIYTILP TQSPQETFGC FIVGGATTSA FSQAEVNVGK VSYLYNSTTA
660 670 680 690 700
ESFSYELQLQ VSDGIETSET VYLPVSVHPL ELRLVNNTGL IMIHKSSLPI
710 720 730 740 750
STANLSIGTN AVDDHIDIRY DIVKAPQHGV LQRLRQIDGS WVNVDWFSDS
760 770 780 790 800
QLLLGHIRYL HSSDFPWQDE FKFIASFGFV TTQTFDFRIT FTRLRITSTR
810 820 830 840 850
PSQISINGSR EILLTSDVLS YETTPIGSFA RSVIYKITKP TRYGGIYVEG
860 870 880 890 900
SRKAAKKLDS FTQQDIEKRR IRYQTHHTSY SSFSDHLEFV VSVAECDDVA
910 920 930 940 950
GVLEINYRPP DELINKLGYQ NHEPLQVQEG ERALITKNHF GIRFNIYESL
960 970 980 990 1000
QFQVSLSPEH GVICKYDEQT GLTTPVEMFT LEQLFRNDIY YCHDDTESTR
1010 1020 1030 1040 1050
DTFELLILSG DETDLQFVSN MEVHIKLVND NEPYRTAIER VFHVVRNGIR
1060 1070 1080 1090 1100
TLNPTVLQYL DADVNTNHTD IHYIHVSSTN GAFYKSGHYI DSFTQDDIAN
1110 1120 1130 1140 1150
RRIMFQHTGA DSGTASFIVT DREHEVNGLL EIRASDPFVS MMATNASIVQ
1160 1170 1180 1190 1200
EGKFVVLKNK DFILETNLDM KLDEIYYEVI KPPSYGILMY LSRANEGENG
1210 1220 1230 1240 1250
TTIYKATNYT SLSNFTHLDI ERERLVYWNT EIASMDKVRY RVHIKNITAE
1260 1270 1280 1290 1300
GEVMFRIYPS AYWEPLQVKQ NHTLYVEEST SVLISRDVLE VVHPNISPGD
1310 1320 1330 1340 1350
ITFLVTSSPM HGYLEMQSMS FDDEYNCKVF DQSSVNTEKM FYIQAGVNQS
1360 1370 1380 1390 1400
TDYFVFDVTN GITWLRQLMI KIVIIPEKLY MHSNIISVVE GKTVQLNPTD
1410 1420 1430 1440 1450
IQPYSEYYRG KILEYIVTIT PSSGHVLAGN SKVKRFTQKQ LEQGSIQYVH
1460 1470 1480 1490 1500
NGSENATDSI TLVAMARNKE SVPFELEFAV VQVNDEEPMM VTNTGLQVWN
1510 1520 1530 1540 1550
GGRYVIKNTD LLAQDYDTPP ENLTFVVNHI YGGYLARKSA PHQKIEHFTQ
1560 1570 1580 1590 1600
AQINLEEIYF MHDSNSRRNE LSFVVTDGLF NTTTQMLNIE IKPIEILAEH
1610 1620 1630 1640 1650
NENLHVFPLT KKQILRDYLH FKCSDEEREI RYNITVPPSL GRIVNEFIDN
1660 1670 1680 1690 1700
GFTKEVSEFT QNDVDNGHIF YEHTAVIMEF RTNDSFYFDV VAERSDRLLN
1710 1720 1730 1740 1750
QKFNIEISVS SGGLLRFLPV NKLNVDEGGS VPIKLDFSKI LEYLKTKAGI
1760 1770 1780 1790 1800
NNPELFIEAI QKPTHGNIGL GHEFKHMQRY HPSDFFTKKV YYIHDHSDTL
1810 1820 1830 1840 1850
EDTILMSVYL TQGNIFLCNL TIPVSINPIN DQPFHLVTHL PQMTVVEGEN
1860 1870 1880 1890 1900
RTITRNDLLT EDADTPPEEI IYDVMSGPTL GVLRKITNDG RPEDLLAFSN
1910 1920 1930 1940 1950
QFTQADINND RIIYVHFGMP QSTTFCFTVS DGQSNPAYEI FTIKIDSIHL
1960 1970 1980 1990 2000
QPSAMQAPVK VQQGATTAPM RLDHIGVSTN VHMERLSYNV TNSPLFGIIV
2010 2020 2030 2040 2050
YKHQPTLRFT QQQLETSQIS YMQTDLNRSN DSFQVSAYVP GTNYVAQVDV
2060 2070 2080 2090 2100
VMEVEPVIQI NDIVMKEAES SGGKIKLITS LDNDNPLSLK LNKFNPKFVI
2110 2120 2130 2140 2150
TRMPSTGQIR KIIRSTGLTT DGQSDRSTNI FSYKELRSGV VYFVPHESVE
2160 2170 2180 2190 2200
ETEADHDSFD YQLLIKTVQP AQATVSIEYR SRVEETETVH LGSAGLSINY
2210 2220 2230 2240 2250
LAIGCAIFIV LICLLIVLLI LKIRKLRKHK ADISKDQPPA LPCPPDLTSV
2260 2270 2280 2290 2300
SPQHHLHHHH GHHYASSEAD SVPATGNSTP LPGFSNIPHC KIIPVESYKH
2310 2320 2330 2340 2350
EYPDYDPDEE ETDDQCDPQQ MMLPQRYNPY HMEHDAWSSS CDMANDFAGY
2360 2370 2380
ASVPQSISGS VSSPPSAPPT NPLLRRNQYW V
Length:2,381
Mass (Da):270,658
Last modified:April 3, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FCE5482EC821720
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF428975 mRNA Translation: ABO20847.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF428975 mRNA Translation: ABO20847.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiA3RLX3, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3597 Eukaryota
ENOG410XQ29 LUCA

Gene expression databases

BgeeiFBgn0032683 Expressed in 20 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G
PfamiView protein in Pfam
PF02210 Laminin_G_2, 2 hits
SMARTiView protein in SMART
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 14 hits
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA3RLX3_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A3RLX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 31, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again