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Protein

Thymidine kinase

Gene

UL23

Organism
Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Binding sitei199ATPUniRule annotation1
Binding sitei205SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:UL23Imported
Synonyms:TKUniRule annotation
OrganismiCercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)Imported
Taxonomic identifieri10325 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca leonina (Northern pig-tailed macaque) (Macaca nemestrina leonina) [TaxID: 90387]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]
Macaca nemestrina (Pig-tailed macaque) [TaxID: 9545]
Proteomesi
  • UP000134119 Componenti: Genome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075062

Expressioni

Keywords - Developmental stagei

Early proteinUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A3RLP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASHAGHQDS PALDRVAGSA GHGDHPSALL RIYVDGPHGL GKTTTAAALA
60 70 80 90 100
AALGRRDEIE YVPEPMAYWQ TLGGPQTITR IFDAQHRLDR GEISASEAAM
110 120 130 140 150
AMASAQVTMS TPYAVTESAV APHIGAELPP GHGPHPNIDL TLVFDRHPVA
160 170 180 190 200
SLLCYPAARY LMGSLSLPTV LSFAALLPQT TPGTNLVLGA LPEAVHAERL
210 220 230 240 250
AQRQRPGERL DLAMLSAIRR VYDMLGNAIV YLQRGGSWRA DWRRLSPARS
260 270 280 290 300
AAASGRPARI LPRPEIEDTI FALFCAPELL DETGEPYRVF AWTLDLLAER
310 320 330 340 350
LRPMHLLVLD YNQAPHHCWM DLMEMIPEMT PTLPATPGSM LTLQLLAREF
360 370
AREMTSTRGG DVGGEGRETR
Length:370
Mass (Da):40,206
Last modified:April 3, 2007 - v1
Checksum:i39287C8A185FF5DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF426678 Genomic DNA Translation: ABO20839.1
KJ566591 Genomic DNA Translation: AIA09516.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF426678 Genomic DNA Translation: ABO20839.1
KJ566591 Genomic DNA Translation: AIA09516.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1075062

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA3RLP8_CHV1
AccessioniPrimary (citable) accession number: A3RLP8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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