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Protein
Submitted name:

Calpain-8

Gene

CAPN8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi41 – 52PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi71 – 82PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain-8Imported
Gene namesi
Name:CAPN8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000203697.11
HGNCiHGNC:1485 CAPN8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000203697

PTM / Processingi

Proteomic databases

MaxQBiA3QK37
PeptideAtlasiA3QK37
PRIDEiA3QK37

Expressioni

Gene expression databases

BgeeiENSG00000203697 Expressed in 114 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiA3QK37 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliA3QK37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 63EF-handInterPro annotationAdd BLAST36
Domaini71 – 93EF-handInterPro annotationAdd BLAST23
Domaini123 – 156EF-handInterPro annotationAdd BLAST34

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000197951
HOVERGENiHBG004492

Family and domain databases

InterProiView protein in InterPro
IPR029543 CAPN8
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR10183:SF374 PTHR10183:SF374, 1 hit
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13833 EF-hand_8, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

A3QK37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DSEITANALK ILLNEAFSKR TDIKFDGFNI NTCREMISLL DSNGTGTLGA
60 70 80 90 100
VEFKTLWLKI QKYLEIYWET DYNHSGTIDA HEMRTALRKA GFTLNSQVQQ
110 120 130 140 150
TIALRYACSK LGINFDSFVA CMIRLETLFK LFSLLDEDKD GMVQLSLAEW

LCCVLV
Length:156
Mass (Da):17,734
Last modified:April 3, 2007 - v1
Checksum:iB04CC6F34E44E56F
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NHC0CAN8_HUMAN
Calpain-8
CAPN8 NCL2
703Annotation score:
B1B154B1B154_HUMAN
Calpain-8
CAPN8
381Annotation score:
H0YEJ4H0YEJ4_HUMAN
Calpain-8
CAPN8
173Annotation score:
B1B153B1B153_HUMAN
Calpain-8
CAPN8
437Annotation score:
A3QK36A3QK36_HUMAN
Calpain-8
CAPN8
101Annotation score:
H0YDN4H0YDN4_HUMAN
Calpain-8
CAPN8 hCG_2036808
38Annotation score:
H0YEQ4H0YEQ4_HUMAN
Calpain-8
CAPN8
20Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABBA01006375 Genomic DNA No translation available.
ABBA01008160 Genomic DNA No translation available.
AC099065 Genomic DNA No translation available.
CR628412 Genomic DNA No translation available.
FO681503 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000430824; ENSP00000390294; ENSG00000203697
UCSCiuc057pse.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABBA01006375 Genomic DNA No translation available.
ABBA01008160 Genomic DNA No translation available.
AC099065 Genomic DNA No translation available.
CR628412 Genomic DNA No translation available.
FO681503 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliA3QK37
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiA3QK37
PeptideAtlasiA3QK37
PRIDEiA3QK37

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000430824; ENSP00000390294; ENSG00000203697
UCSCiuc057pse.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000203697.11
HGNCiHGNC:1485 CAPN8
OpenTargetsiENSG00000203697
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000197951
HOVERGENiHBG004492

Miscellaneous databases

ChiTaRSiCAPN8 human

Gene expression databases

BgeeiENSG00000203697 Expressed in 114 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiA3QK37 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029543 CAPN8
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR10183:SF374 PTHR10183:SF374, 1 hit
PfamiView protein in Pfam
PF13202 EF-hand_5, 1 hit
PF13833 EF-hand_8, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA3QK37_HUMAN
AccessioniPrimary (citable) accession number: A3QK37
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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