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Protein

LexA repressor

Gene

lexA

Organism
Shewanella loihica (strain ATCC BAA-1088 / PV-4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei122For autocatalytic cleavage activityUniRule annotation1
Active sitei159For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Repressor
Biological processDNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciSLOI323850:G1G8D-128-MONOMER

Protein family/group databases

MEROPSiS24.001

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
Ordered Locus Names:Shew_0127
OrganismiShewanella loihica (strain ATCC BAA-1088 / PV-4)
Taxonomic identifieri323850 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001558 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000013371 – 205LexA repressorAdd BLAST205

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei87 – 88Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavage

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi323850.Shew_0127

Structurei

3D structure databases

ProteinModelPortaliA3Q951
SMRiA3Q951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DS7 Bacteria
COG1974 LUCA
HOGENOMiHOG000232167
KOiK01356
OMAiRQMMQAM
OrthoDBiPOG091H029U

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00015 LexA, 1 hit
InterProiView protein in InterPro
IPR006200 LexA
IPR036286 LexA/Signal_pep-like_sf
IPR006199 LexA_DNA-bd_dom
IPR006197 Peptidase_S24_LexA
IPR015927 Peptidase_S24_S26A/B/C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01726 LexA_DNA_bind, 1 hit
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00726 LEXASERPTASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR00498 lexA, 1 hit

Sequencei

Sequence statusi: Complete.

A3Q951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLTPRQAE ILDLIKRNIA DTGMPPTRAE IARRLGFKSA NAAEEHLKAL
60 70 80 90 100
AKKGCIEIMP GTSRGIKLTQ EEEPEDLGLP LIGQVAAGEP ILAQEHVEQH
110 120 130 140 150
YQVDPSMFRP SADFLLRVRG DSMKDIGILE GDLLAVHKVE QARNGQIVVA
160 170 180 190 200
RVEDDVTVKR FEKRGSTVYL HAENEEYSPI VVDLTTQSLS IEGLAVGVIR

NGDWQ
Length:205
Mass (Da):22,668
Last modified:April 17, 2007 - v1
Checksum:i326689492A1DA062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000606 Genomic DNA Translation: ABO21999.1
RefSeqiWP_011863936.1, NC_009092.1

Genome annotation databases

EnsemblBacteriaiABO21999; ABO21999; Shew_0127
KEGGislo:Shew_0127

Similar proteinsi

Entry informationi

Entry nameiLEXA_SHELP
AccessioniPrimary (citable) accession number: A3Q951
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 17, 2007
Last modified: June 20, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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