Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein GrpE

Gene

grpE

Organism
Prochlorococcus marinus (strain MIT 9301)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Enzyme and pathway databases

BioCyciPMAR167546:G1G8B-17-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:P9301_00151
OrganismiProchlorococcus marinus (strain MIT 9301)
Taxonomic identifieri167546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000001430 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000536131 – 239Protein GrpEAdd BLAST239

Proteomic databases

PRIDEiA3PA63

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi167546.P9301_00151

Structurei

3D structure databases

ProteinModelPortaliA3PA63
SMRiA3PA63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107Z9D Bacteria
COG0576 LUCA
HOGENOMiHOG000252083
KOiK03687
OMAiYAYEKIA
OrthoDBiPOG091H00J8

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit

Sequencei

Sequence statusi: Complete.

A3PA63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENQSDNID NKEIDVSIQD NAPEDKSSMQ NSTTENDELS SQKTEEINTE
60 70 80 90 100
ELKNTISNND ARLEQLEKEH ETLKNQYVRI SADFDNFRKR QSRDQDDLKI
110 120 130 140 150
QLVSKTLTAI LPIVDNFERA RQQLKPESEE AQALHRSYQG LYKQLVEVLK
160 170 180 190 200
QQGVSPMRVV GQQFDPNLHE AVLREPSEEF EEDFIIEELQ RGYHLEGKVL
210 220 230
RHALAKVSMG PGKQKSQQEV EKDTVEGDVD SDANTSEDV
Length:239
Mass (Da):27,443
Last modified:April 3, 2007 - v1
Checksum:iA469718BD8C5A576
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000576 Genomic DNA Translation: ABO16638.1
RefSeqiWP_011862043.1, NC_009091.1

Genome annotation databases

EnsemblBacteriaiABO16638; ABO16638; P9301_00151
GeneIDi4912361
KEGGipmg:P9301_00151

Similar proteinsi

Entry informationi

Entry nameiGRPE_PROM0
AccessioniPrimary (citable) accession number: A3PA63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: April 3, 2007
Last modified: March 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health