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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Burkholderia pseudomallei (strain 668)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBPSE320373:G1G88-3056-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:BURPS668_3011
OrganismiBurkholderia pseudomallei (strain 668)
Taxonomic identifieri320373 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group
Proteomesi
  • UP000002153 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003822881 – 427Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA3NCF3
SMRiA3NCF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020210
KOiK01845

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A3NCF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNNQTLFER AQRTIPGGVN SPVRAFRSVG GTPRFVARAQ GAYFWDADGK
60 70 80 90 100
RYIDYIGSWG PMIVGHVHPD VLAAVQHVLA DGFSFGAPTE AEIEIAEEIC
110 120 130 140 150
KLVPSIEQVR MVSSGTEATM SALRLARGFT GRSRIVKFEG CYHGHADSLL
160 170 180 190 200
VKAGSGLLTF GNPTSAGVPA DVAKHTTVLE YNNVAALEEA FAAFGGEIAA
210 220 230 240 250
VIVEPVAGNM NLVRGTPEFL NALRALTAKH GAVLIFDEVM CGFRVALGGA
260 270 280 290 300
QQHYGITPDL TCLGKVIGGG MPAAAFGGRG DIMSHLAPLG GVYQAGTLSG
310 320 330 340 350
NPVAVAAGLA TLRLIQAPGF HDALADKTRR LADSLAAEAR AAGVPFSADA
360 370 380 390 400
IGGMFGLYFT EQVPASFADV TKSDIERFNR FFHLMLDAGV YFAPSAYEAG
410 420
FVSSAHDDAT LDATLDAARR AFAALRA
Length:427
Mass (Da):44,809
Last modified:September 1, 2009 - v2
Checksum:i4A06BFA5B7C64E60
GO

Sequence cautioni

The sequence ABN84156 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000570 Genomic DNA Translation: ABN84156.1 Different initiation.
RefSeqiWP_041278459.1, NC_009074.1

Genome annotation databases

EnsemblBacteriaiABN84156; ABN84156; BURPS668_3011
KEGGibpd:BURPS668_3011

Similar proteinsi

Entry informationi

Entry nameiGSA_BURP6
AccessioniPrimary (citable) accession number: A3NCF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 28, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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