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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

apgM

Organism
Pyrobaculum calidifontis (strain JCM 11548 / VA1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (Pcal_0029)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
aPGAMUniRule annotation
Gene namesi
Name:apgMUniRule annotation
Ordered Locus Names:Pcal_1668
OrganismiPyrobaculum calidifontis (strain JCM 11548 / VA1)
Taxonomic identifieri410359 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000001431 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000873691 – 4112,3-bisphosphoglycerate-independent phosphoglycerate mutaseAdd BLAST411

Proteomic databases

PRIDEiA3MWR8

Interactioni

Protein-protein interaction databases

STRINGi410359.Pcal_1668

Structurei

3D structure databases

ProteinModelPortaliA3MWR8
SMRiA3MWR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01696 Archaea
COG3635 LUCA
HOGENOMiHOG000004785
KOiK15635
OMAiGDIAFRC
OrthoDBiPOG093Z02JY

Family and domain databases

CDDicd16011 iPGM_like, 1 hit
Gene3Di3.40.720.10, 2 hits
HAMAPiMF_01402_A ApgM_A, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR023665 ApgAM_prokaryotes
IPR006124 Metalloenzyme
IPR004456 Pglycerate_mutase_ApgM
PANTHERiPTHR31209 PTHR31209, 1 hit
PfamiView protein in Pfam
PF01676 Metalloenzyme, 1 hit
PF10143 PhosphMutase, 1 hit
PIRSFiPIRSF006392 IPGAM_arch, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
TIGRFAMsiTIGR00306 apgM, 1 hit

Sequencei

Sequence statusi: Complete.

A3MWR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSVLWILFD GGGDRPNGGK TPFHVAFKPT IDYLTSLGSC GLLDPISPGV
60 70 80 90 100
RPGSDTAHLA LFGYDPYKYY TGRGAFEALG AGIELRPGDV AFRTNLATVD
110 120 130 140 150
SSGVVIDRRA GRYIAPEETR AVEEVMAKIG DEVAKRYGVE VVYKSTVEHR
160 170 180 190 200
GVLVLRGPVS HKVSDTDPHK VGMPVAKAAP LGNDREAALT AEVVNYITAR
210 220 230 240 250
FTEAAGGLEI NKARAASGRP PINAILLRGG GYMPAIEPVA EKYRVKAAAI
260 270 280 290 300
AGVALIRGVA KAVGMDVYTA QGLGGTKDDV FDHAVKLAVE LMGKYDVVFL
310 320 330 340 350
HVKGTDSTSH DGDFQGKVAV IERLDKALAP YLDHLLKNYF IVTSDHATPV
360 370 380 390 400
SIREHTGEPV PLTLYGPDVV PDDVAKFSEL TCWRGALGRL RGIDIMPILA
410
SYLGLSEKFG E
Length:411
Mass (Da):43,940
Last modified:April 3, 2007 - v1
Checksum:iEB97F9F82983C0E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000561 Genomic DNA Translation: ABO09085.1

Genome annotation databases

EnsemblBacteriaiABO09085; ABO09085; Pcal_1668
KEGGipcl:Pcal_1668

Similar proteinsi

Entry informationi

Entry nameiAPGM_PYRCJ
AccessioniPrimary (citable) accession number: A3MWR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 3, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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